ID   B0WAJ0_CULQU            Unreviewed;       334 AA.
AC   B0WAJ0;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   27-MAR-2024, entry version 82.
DE   SubName: Full=Serine protease {ECO:0000313|EMBL:EDS41413.1, ECO:0000313|EnsemblMetazoa:CPIJ004094-PA};
GN   Name=6035568 {ECO:0000313|EnsemblMetazoa:CPIJ004094-PA};
GN   ORFNames=CpipJ_CPIJ004094 {ECO:0000313|EMBL:EDS41413.1};
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1] {ECO:0000313|EMBL:EDS41413.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB {ECO:0000313|EMBL:EDS41413.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA   Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:CPIJ004094-PA}
RP   IDENTIFICATION.
RC   STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ004094-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family. CLIP subfamily.
CC       {ECO:0000256|ARBA:ARBA00024195}.
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DR   EMBL; DS231872; EDS41413.1; -; Genomic_DNA.
DR   RefSeq; XP_001845724.1; XM_001845672.1.
DR   AlphaFoldDB; B0WAJ0; -.
DR   MEROPS; S01.B41; -.
DR   EnsemblMetazoa; CPIJ004094-RA; CPIJ004094-PA; CPIJ004094.
DR   KEGG; cqu:CpipJ_CPIJ004094; -.
DR   VEuPathDB; VectorBase:CPIJ004094; -.
DR   VEuPathDB; VectorBase:CQUJHB011226; -.
DR   eggNOG; KOG3627; Eukaryota.
DR   HOGENOM; CLU_832247_0_0_1; -.
DR   InParanoid; B0WAJ0; -.
DR   OrthoDB; 3059419at2759; -.
DR   Proteomes; UP000002320; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   PANTHER; PTHR24252; ACROSIN-RELATED; 1.
DR   PANTHER; PTHR24252:SF7; HYALIN; 1.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Hydrolase {ECO:0000313|EMBL:EDS41413.1};
KW   Membrane {ECO:0000256|SAM:Phobius}; Protease {ECO:0000313|EMBL:EDS41413.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        117..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          212..334
FT                   /note="Peptidase S1"
FT                   /evidence="ECO:0000259|PROSITE:PS50240"
SQ   SEQUENCE   334 AA;  37199 MW;  C9EC36B123A162C8 CRC64;
     MPLSTNRHHR QQQHSLLIVI NITIIEESAQ MREISRAKRE KEKIRRPHSG FVGSAHVQVT
     RPRAEESLRR SRRRMALNSL IVVGRPVQTC AVLSLSVSVK GENMSQMALL SRGRVPSLVV
     MVAVICCWML ATTTLVVEAK LAARGKYEMM ATPASSSASS SSSGKNPDEH RGIIDNVKMM
     FGGGASNRAP AHDTPASACS CRCGERNDAS RIVGGQPTGI NEFPWMARLS YFNRFYCGGM
     LINDRYVLTA AHCVKGFMWF MIKVTFGEHN RCDDSVRPET RFVLRAIAQK FSFLNFDNDI
     ALLRLNDRVP ITDFIRPICL PSDPLGIDSP DNFT
//