ID B0WF10_CULQU Unreviewed; 1045 AA.
AC B0WF10;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 103.
DE SubName: Full=ATP-dependent RNA helicase DOB1 {ECO:0000313|EMBL:EDS25918.1, ECO:0000313|EnsemblMetazoa:CPIJ005981-PA};
GN Name=6037371 {ECO:0000313|EnsemblMetazoa:CPIJ005981-PA};
GN ORFNames=CpipJ_CPIJ005981 {ECO:0000313|EMBL:EDS25918.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS25918.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS25918.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ005981-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ005981-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
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DR EMBL; DS231913; EDS25918.1; -; Genomic_DNA.
DR RefSeq; XP_001847294.1; XM_001847242.1.
DR AlphaFoldDB; B0WF10; -.
DR STRING; 7176.B0WF10; -.
DR EnsemblMetazoa; CPIJ005981-RA; CPIJ005981-PA; CPIJ005981.
DR GeneID; 6037371; -.
DR KEGG; cqu:CpipJ_CPIJ005981; -.
DR VEuPathDB; VectorBase:CPIJ005981; -.
DR VEuPathDB; VectorBase:CQUJHB004697; -.
DR eggNOG; KOG0948; Eukaryota.
DR HOGENOM; CLU_002902_0_1_1; -.
DR InParanoid; B0WF10; -.
DR OMA; IMLKNYN; -.
DR OrthoDB; 1352at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR CDD; cd18024; DEXHc_Mtr4-like; 1.
DR CDD; cd13154; KOW_Mtr4; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.3380.30; -; 2.
DR Gene3D; 2.40.30.300; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR048392; MTR4-like_stalk.
DR InterPro; IPR025696; MTR4_beta-barrel.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016438; SKI2-like.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF7; EXOSOME RNA HELICASE MTR4; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08148; DSHCT; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21408; MTR4-like_stalk; 1.
DR Pfam; PF13234; MTR4_beta-barrel; 1.
DR PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01142; DSHCT; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:EDS25918.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320}.
FT DOMAIN 149..305
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 378..582
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..24
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..52
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1045 AA; 118714 MW; AA9D3F6E06F57A5D CRC64;
MAAVDDLFNL FDAENEEEDD GGSVPIVVPE DKPGKIEVDD DGDEGAVKEA EPVATKRELE
KIEVDDEDDD DVEEVEPCKK AKLVESLLDD INLDNIESRI KVHTIQSPEA CTHEVAVYPD
HKYMPLVAPT GKPAKEYQFV LDPFQKEAIL CIENQQSVLV SAHTSAGKTV VAEYAIAKSL
AEKQRVIYTT PIKALSNQKY REFHEEFKDV GLVTGDVTIN PSASCLIMTT EILRNMLYRG
SEIMREVGWV VFDEIHYMRD KERGVVWEET LILLPDNVHY VFLSATIPNA RQFAEWVCHI
HKQPCHVVYT DYRPTPLQHY LFPVGGDGIH LVVDEKGTFK EDNFNTAMAV LQNAGEAAKG
DQKGKKGGLK ATNSGETNIF KIVKMIMERN FAPVIIFSFS KKDCEIYAMQ MSKLDFNSTT
EKKLVDEVFN NAMDVLSEED RQLPQVENVL PLLRRGIGIH HGGLLPILKE TIEILFGEGL
IKALFATETF AMGLNMPART VLFTGPRKFD GKDFRWVTSG EYIQMSGRAG RRGLDDKGIV
ILMIDEAVSP AVGKEIVQGK PDPINSAFHL TYNMVLNLLR VEEINPEYML ERSFFQFQNQ
SSIPEIYKKV QRKQKELEGV HIKDEQSIMT YHNVREQLDT LGKQFRDYIT RPTYLVPFLQ
PGRMIKIKSD AGEFEWGIIV NFKKETVDAK ANPLKSETKV IIDVLLHVDD GFEKEGVPKP
CPPSKRGSVE VVPVLHSLVH RISSLRVYYP NDLRPADNRR SVLKTINEVK KRFPAGPPLL
NPINDMHIKE KDFQDTVDLI DKFEKRLFAH PLHDSPELDK LYTKYMGKLE IERALKQEKN
SLREAKSLLH MDELKHRKRV LRRLGYCTTA DVIEFKGRVA CELSCADELL LTEMIFNGTF
TNLTTAQACA LLSCFVCDEK STELPAATEE LSGPLRQMQD LARRIAKVSN ECKVELDEER
YVESFKPFLM DVVLAWCKGS SFLQLCKMTD IFEGSIIRCM RRLEELLRQM VQASKTIGNT
DLENKFADAI RLLKRDIVFA ASLYL
//
