UniProt: B0WG78

Database: UniProt
Entry: B0WG78_CULQU

LinkDB:  B0WG78_CULQU 
Original site:  B0WG78_CULQU

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Ontology (13)   
   GO (13)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (30)   
   InterPro (18)   
   Pfam (11)   
   SMART (1)   
All databases (47)   

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ID   B0WG78_CULQU            Unreviewed;      4154 AA.
AC   B0WG78;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   27-MAR-2024, entry version 107.
DE   RecName: Full=Cytoplasmic dynein 2 heavy chain 1 {ECO:0000256|ARBA:ARBA00023902};
GN   Name=6037839 {ECO:0000313|EnsemblMetazoa:CPIJ005887-PA};
GN   ORFNames=CpipJ_CPIJ005887 {ECO:0000313|EMBL:EDS26774.1};
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1] {ECO:0000313|EMBL:EDS26774.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB {ECO:0000313|EMBL:EDS26774.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA   Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:CPIJ005887-PA}
RP   IDENTIFICATION.
RC   STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ005887-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC       {ECO:0000256|ARBA:ARBA00008887}.
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DR   EMBL; DS231923; EDS26774.1; -; Genomic_DNA.
DR   RefSeq; XP_001847712.1; XM_001847660.1.
DR   STRING; 7176.B0WG78; -.
DR   EnsemblMetazoa; CPIJ005887-RA; CPIJ005887-PA; CPIJ005887.
DR   GeneID; 6037839; -.
DR   KEGG; cqu:CpipJ_CPIJ005887; -.
DR   VEuPathDB; VectorBase:CPIJ005887; -.
DR   VEuPathDB; VectorBase:CQUJHB005485; -.
DR   eggNOG; KOG3595; Eukaryota.
DR   HOGENOM; CLU_000038_7_2_1; -.
DR   InParanoid; B0WG78; -.
DR   OMA; WCKERVS; -.
DR   OrthoDB; 312195at2759; -.
DR   Proteomes; UP000002320; Unassembled WGS sequence.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR   GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR   GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR   GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR   GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR   GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR   Gene3D; 1.10.287.2620; -; 1.
DR   Gene3D; 1.10.8.710; -; 1.
DR   Gene3D; 1.20.1270.280; -; 1.
DR   Gene3D; 1.20.58.1120; -; 1.
DR   Gene3D; 1.20.920.20; -; 1.
DR   Gene3D; 1.20.920.30; -; 1.
DR   Gene3D; 3.10.490.20; -; 1.
DR   Gene3D; 6.10.140.1060; -; 1.
DR   Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR   Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR035699; AAA_6.
DR   InterPro; IPR035706; AAA_9.
DR   InterPro; IPR041658; AAA_lid_11.
DR   InterPro; IPR042219; AAA_lid_11_sf.
DR   InterPro; IPR026983; DHC_fam.
DR   InterPro; IPR049400; DYNC2H1_AAA_dom.
DR   InterPro; IPR042222; Dynein_2_N.
DR   InterPro; IPR043157; Dynein_AAA1S.
DR   InterPro; IPR041228; Dynein_C.
DR   InterPro; IPR043160; Dynein_C_barrel.
DR   InterPro; IPR024743; Dynein_HC_stalk.
DR   InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR   InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR   InterPro; IPR013602; Dynein_heavy_linker.
DR   InterPro; IPR013594; Dynein_heavy_tail.
DR   InterPro; IPR042228; Dynein_linker_3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10676:SF352; CYTOPLASMIC DYNEIN 2 HEAVY CHAIN 1; 1.
DR   PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR   Pfam; PF12774; AAA_6; 1.
DR   Pfam; PF12775; AAA_7; 1.
DR   Pfam; PF12780; AAA_8; 1.
DR   Pfam; PF12781; AAA_9; 1.
DR   Pfam; PF18198; AAA_lid_11; 1.
DR   Pfam; PF08385; DHC_N1; 1.
DR   Pfam; PF08393; DHC_N2; 1.
DR   Pfam; PF21264; DYNC2H1_AAA_dom; 1.
DR   Pfam; PF18199; Dynein_C; 1.
DR   Pfam; PF03028; Dynein_heavy; 1.
DR   Pfam; PF12777; MT; 1.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF90257; Myosin rod fragments; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Cilium {ECO:0000256|ARBA:ARBA00023069};
KW   Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Dynein {ECO:0000256|ARBA:ARBA00023017};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW   Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002320}.
FT   DOMAIN          1612..1749
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          2205..2349
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   COILED          2770..2803
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2975..3072
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   4154 AA;  475261 MW;  431ABDBD4885012C CRC64;
     MTNRFKFIHD TAVEFFNASN AENSEIITDF LENDDVTILA AVSLDGEVLF QNAVPVEEQY
     CLLFYKIPNL DYHSPATAPK IGMLTLEGGL AKSIYNSLQR VFSPYILKKS EYSSEVKNIL
     QNLHSNLGLS LGLTESGILS IQDEIGFWVQ KTRTLPTKAD REAARSFAEI LEKVNSSMKD
     STEGNLTQLD DFIDVCQSHL DEIWRLPNHY PQNRMCSIFD LISTHVVTTC TENLNELDIW
     DTGSILLDAA INHVKETLEA WYQTFDSLTR LFWPNYEQHG WIGDPYKSKQ LDKFRTRYTE
     ILEIKNSKDL LYALFFDSDE YFINISDIAE PFKEINIYDL TPLGNKRWEV AKSRMEASLV
     KIDEKIVALL KQQIHESVGN PRQAIHVFDR YKDIFNRPYV LKTLTVEREQ LFQSIPTIIR
     ELRELLTNAN YTEDDVTPIV SETRWYRVVE KQIGQLEAVA SKILHDRDGF ERALGKITAF
     HEEIQAMIHT NFESWTENSK SAIRDGELSL RENQPVVIFD KAERQLMKVT FGPKIVTFCD
     EARHLQNLGL KLDPEIQKSI THSTKFISYA RRLQQIALFH NTIGDRMIPC QRPIMLKNAM
     EFANLVKSES VSWNDEDSVE RYITSLQDAI KRLSKDNNAL TGYHEQAKKS VLKLMDTDLI
     RQSNVWKEEM RTLREIIFNL EKQGYTNLNP FKLHWDHQLY KVLEYQYVAG LLDVHQKLPD
     IHVDLVFRQQ QIQFRPTLEE VKSKYYSQLR RFIEKPLGFK GLSEQSSTIF KVMIERNAQH
     FSVLYEKAEI VFRELIEFRD SWTPFIALGM TDMEQLCTVH CTTWQHWDNN FRACKKFSQQ
     IARIQQSEKE IDCLIVNYAP LCSDVDAISR RYWEALSNSL RTSILDSISV LQEYLAYSFQ
     VLQNIPQDEW GISESSAKYE KIVCDLPKMT ELMKSLQGKD SCLAGWCKER VSALGGILIQ
     WNQLQPLIEN HQTLLQGRLD IIKENILRQI NELNNEAEKF SIRWESTIRD LETNDNADMT
     LFRERQGQWQ TIISQRETLR KQTEKFNIKV PENYDEIFTK LEAEIRDQGK NWEIFNEFTN
     DYDTVANEEW TIYRRRPHIL TDFLARWEKS PNQPPSVAST RIVSTMERYR ACIPILSSLQ
     SEALIEKHWA KICQLLKIDS KSQHDLCLGD VLAVSENLQL QAAEIQSIVR QAASEHVIRQ
     AIVELEQWSA TAMLKLIEHT DSKGSAVALI KDYTETLNKI GDNQFLLQSA KNSASFESFS
     DQANVWEEKL NNLEYIITHL NQIQKKWIYL QPIFGAGTLK KEEAVFKSID KNFRYIMKEI
     ADDPRVVSVN RINNVLSIIE TLQSQISRCQ NALSSYITTK RNVFSRFYFL SDDDLLEILG
     QSSKEAIIQK HIRKLFPGIF KLTIQDSRIV TFWSEEGDEV SLTNPISITP PIEEWLNTLV
     AEIKMTLKAL IKKCLESDSF DDRVIRDFPM QIICLVNSIH FTRRTEKAIS GMQLADLKRH
     IQSEINRFST LLHNSTDTLT QIKLRSLLID LVYQSTTVDY LSNHNVTNLQ DWYWLQQLKF
     YIDRNGTVIV KMVYAEFEYS YEFLGNYNKL VYTSLAHNCY LILTQAMQLG LGGNPFGPAG
     TGKTECVKSL GAMLGRLVLV FNCDEKIDTA AMALILSGLA RSGAWGCFDE FNRLQEATLS
     AISMLIQPLQ VALKDKQQEV QLNNATIPLN SHCCVFVTLN PAGEEYGGRQ QLPLNLQALF
     RPIAMQAPRP QQIARVTLFV EGFKHADQIG AQIVELFELA NKMLSKQRHY DWGLRELKAI
     LSACGSALKG SQDELSYDQE AGLAVNVIRS NTMSRLTLAD CRRFDILLCS VFPKVAIASA
     HNEELRSKVV DAFSVLGFQQ NNRQVDKCLE LAAQLQKRMG VVVIGPPRSG KSTIIAVLKE
     ALLAQGNTIR AHIISPKSMN RVQLLGNLDP DTRQWTDGVL TSTAVAVNAE PRTVTSWIIC
     DGDVDPEWIE ALNSVLDDNR LLTLPSGWRI QFGSNVNFIF ETHDLSTASP ATISRMGIIN
     LNEEDLPYQL IVNAWLAKQA NADILKSYLE QHFFKAIDWI EERKFRPVGY SLVSLAESAL
     LAIDGVKCNE QFCADLLCGL NGVLNSDAKN KLSNQVYSWA NITVTDSSVA EYHYYNSFRD
     MIELYSTDEI AGSFINENVY TNVLVKTPLM KLNGELLKHI IGCKNRQVAL LAGPSGNGKS
     LLLQTIVAEF NGYQLVTINC SAQLKTSSIL NTLKQNSLVL TTVKGKEYRP KFSRIVLYFK
     NIDLCSIDSW GTCEVVELLL QIINRSGFYS DTLEWISVSG IQICASLSDL SKVQISPRFL
     SISHLVRIGY PNQSDMESIV KSMILPIYNQ LGKTATKLKL NDLVRAIMNI YFEIQSRFNR
     SEVLHYRFTP KMIERWISGI LHYPEENFSQ ALRYECNRIF RDRLVTDDDR QAFDEIVRDN
     FRMLLESDSS AVFVAKEGQK NSELQLVDRE YLKQMVNQTI EMCNSEVIVV DVPMSDTFLN
     LIASTVRALS RPQTNLVICG KIGSFRLEVI YVACSMLNIK VAFPQTSRNY SLIDFNNDLK
     IVMQNCALEN EPVVFYIDHS VIEYLGDIMK TCEAILEGAE LTDFFGDDLE NLANPLKAQA
     ALESFQMPLA TYFLQRLRNN FHLVILLEHS SPKIRELFEN YSALYHKSEM LWILEDKITP
     CASLTRYLAD IGKDPVVPQP TFFNDLLDGN ISEWTYSPKR RTLLVRSYGH IYTNNKSDKQ
     LYKDKIQIGV DKLSETHKVV EKLKLEAEEK QKALAEKRKL ANQSLEMISS TMRGANDQKT
     ELLELQRKTQ ESSVKLMERK KAIEEELSLV EPILREASAA VGQIKTEALS EIRSLRAPPE
     AVRDILEGVL RLMGIRDTSW NSMKTFLAKR GVKEDIRSLD PVRISPENCA SVEKLLQTKA
     DSYEQKNAKR ASAAAAPLAA WVMANVKYSK VIQSIKPLER EQTELRENLE KAESEMKSLS
     SGLDNVNGKV KELSEQLNSY TQEAAMLEIK LQDAKQTLHS AEVLVQSLSS EYVSWSTELE
     ELNATIANMD KRSFLTAFCI THLSHLSLDQ RKNVLNKIAQ LVREEPFDLD ELITNQDKII
     WESMGLTADQ QYRENATILN QFLMLPFGVT PVPLLVDPTE LGQKWLTSYL QYLNRTFELT
     HQSAERFGYI LELAIRFGKI LIVRNVNLIE PPLLSLFFTR IHSRFNKRMV QVGNKLIDLH
     DDFKLILVTQ NERINLGAEL QAHFMNLMFT TTVAGLTDVL TARWVLAKDP EVEKKRVDLL
     QEEGKLMKEK RSLQNKLLQE LSSSSGDILK NEPLLNTLNS IKASASSIEQ SLGEFVGIRD
     QLMEHYDRRK ELCRLASKFY MGIKRFYSIN VAKLTSIFLT VIDNEKHSSV EELYKLLIRR
     IFSLLSRSTP KNEQMILGLN ICKQAFSEQI PEKEWESFVL NFTNAEHTPD QQIPSWVKQE
     CVPKLIALKQ QHPELYAKLN LDNVNIWEKY VESNDGIVPV GVSDFQSILV AQVLRPDLLI
     RTITRSVQNI LGLKTLYSTR PSIKVLSDES VAEEPLLLIT ASGIDPSDEL REFAKQTIGL
     SKYSEFAVSK GHEQEALKLI TEAASAGGWT CIKNIHTVPH WLRHLDEELK QATPAEGFRL
     WLTSETDRNL YEVFLKKCNK VMFEPPSGLK YKMKLLLEQH GGAATKKRDY KSIKLYVGLF
     LLHSIVQERR SYVPQGWSKW YDFCESDLRT AMQLIRYTEG SNTLKIHWPL IQGLCEKVGY
     GGRIDNDNDF EKLELLLREF FDEKIMTSRW QPMFMNVSFP NSNHLEDYLK VVEQLPDTDT
     PNLYGIPAST NASRDVIFCR NTLKELRQSY FSGGSVQNYE KRIKPIINLW NKLMNATIAT
     RLDSVIDRNR NRHDPWMIFV LSELTTVRNL YEAIDGCLQT IKGSLKEIAT ISGKDRTILT
     TICDNQVPLQ WRRLWSGPKT VIEYLKAIGF KTRETELLYN KVAEENPIVE VNFNNLFNVE
     AFLTTLKMVK SQELGVSTTE LKLCAYFDER KREKAVTVAS LLIDGGCLTN GKLGIQHGTP
     QSGSNLTGPF TLNYAVSTVD QKSSAKREDR FEIALYNNIS RDALICQIAI EIGQGLSRAQ
     LVAAGIALIV PESY
//

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