ID B0WHX2_CULQU Unreviewed; 440 AA.
AC B0WHX2;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Caspase-activated nuclease {ECO:0000313|EMBL:EDS28031.1};
GN Name=6038515 {ECO:0000313|EnsemblMetazoa:CPIJ006433-PA};
GN ORFNames=CpipJ_CPIJ006433 {ECO:0000313|EMBL:EDS28031.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS28031.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS28031.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ006433-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ006433-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
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DR EMBL; DS231940; EDS28031.1; -; Genomic_DNA.
DR RefSeq; XP_001848306.1; XM_001848254.1.
DR AlphaFoldDB; B0WHX2; -.
DR STRING; 7176.B0WHX2; -.
DR EnsemblMetazoa; CPIJ006433-RA; CPIJ006433-PA; CPIJ006433.
DR GeneID; 6038515; -.
DR KEGG; cqu:CpipJ_CPIJ006433; -.
DR VEuPathDB; VectorBase:CPIJ006433; -.
DR VEuPathDB; VectorBase:CQUJHB015193; -.
DR eggNOG; ENOG502R0RF; Eukaryota.
DR HOGENOM; CLU_049235_0_0_1; -.
DR InParanoid; B0WHX2; -.
DR OMA; TPEGWFC; -.
DR OrthoDB; 5399497at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0004520; F:DNA endonuclease activity; IEA:InterPro.
DR GO; GO:0006309; P:apoptotic DNA fragmentation; IEA:InterPro.
DR Gene3D; 3.10.20.10; -; 1.
DR InterPro; IPR003508; CIDE-N_dom.
DR InterPro; IPR039729; DFF40.
DR InterPro; IPR015311; DFF40_C.
DR InterPro; IPR044925; His-Me_finger_sf.
DR PANTHER; PTHR13067; CASPASE-ACTIVATED DNASE; 1.
DR PANTHER; PTHR13067:SF2; CASPASE-ACTIVATED DNASE; 1.
DR Pfam; PF02017; CIDE-N; 1.
DR Pfam; PF09230; DFF40; 1.
DR SMART; SM00266; CAD; 1.
DR SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR SUPFAM; SSF54060; His-Me finger endonucleases; 1.
DR PROSITE; PS51135; CIDE_N; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|PROSITE-ProRule:PRU00447};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320}.
FT DOMAIN 16..91
FT /note="CIDE-N"
FT /evidence="ECO:0000259|PROSITE:PS51135"
FT COILED 118..145
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 440 AA; 50342 MW; 472220185C0FDFEF CRC64;
MFNIRSSPKK PSGAGPLQGY KITNELRSKK YGVAADSLAM LRMKAAEKFK LENCRVYLAQ
DGVEVLDEDY FRTLPAQVLF VVAERDAIVK TDFELMYDAI QQTHSELIEA GSLAKQFVSN
NQTQIARMLE EAQRAQDERT AKSRRSEHAE WFEGFDSRAG QTKEEIMQRR GQDRIRGYFY
KTKDELTKCA IYRGNVMAKE LIDEMLELFR HLLIGFDYFS AIFDRSHPAR LPDNAEVSDL
VVGSGERTVA AAAAASPDGQ EDEVDAQRIV PKRMKLAIKE TLEKDGNAIE RYRVALCNSR
GEFRCMGLWN ERKCKYGAHV INPYASRENM ILFQVWNLDH QVEISRSVLP SIVQNVARVV
AKEADAVCRV HNRRGKKLSV ITYFIELFTL GNLKLVHIVC HDKSIHDMIS RGAIICEKCA
EYKYIKEFQS KIRFNKNALM
//
