ID B0WVH8_CULQU Unreviewed; 579 AA.
AC B0WVH8;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Ionotropic glutamate receptor-invertebrate {ECO:0000313|EMBL:EDS35584.1, ECO:0000313|EnsemblMetazoa:CPIJ010900-PA};
GN Name=6043801 {ECO:0000313|EnsemblMetazoa:CPIJ010900-PA};
GN ORFNames=CpipJ_CPIJ010900 {ECO:0000313|EMBL:EDS35584.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS35584.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS35584.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ010900-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ010900-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
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DR EMBL; DS232126; EDS35584.1; -; Genomic_DNA.
DR RefSeq; XP_001861400.1; XM_001861365.1.
DR AlphaFoldDB; B0WVH8; -.
DR STRING; 7176.B0WVH8; -.
DR EnsemblMetazoa; CPIJ010900-RA; CPIJ010900-PA; CPIJ010900.
DR KEGG; cqu:CpipJ_CPIJ010900; -.
DR VEuPathDB; VectorBase:CPIJ010900; -.
DR VEuPathDB; VectorBase:CQUJHB015380; -.
DR eggNOG; KOG1052; Eukaryota.
DR HOGENOM; CLU_010660_0_0_1; -.
DR InParanoid; B0WVH8; -.
DR OMA; DTLNFVW; -.
DR OrthoDB; 3677745at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0050906; P:detection of stimulus involved in sensory perception; IEA:UniProt.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR PANTHER; PTHR42643; IONOTROPIC RECEPTOR 20A-RELATED; 1.
DR PANTHER; PTHR42643:SF37; IONOTROPIC RECEPTOR 84A; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|SAM:Phobius}; Receptor {ECO:0000313|EMBL:EDS35584.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 143..161
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 341..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 528..552
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 285..540
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00060"
SQ SEQUENCE 579 AA; 66683 MW; 67E4D5063CD9DBEA CRC64;
MDTTYAYVYF NESKDPEVKK LFLKKMKPFG EKAFTEPDVG MKRVRDEFYA FSAEVNAAYL
LIKETFTPQD VCKVHELEAI KLPPFSIPML KGSKYRELFR QRLIWQQEVG INRRYNLMWI
SQKPTCESGT ATFTSVGLTE LRYAYIFMVV GFGVAFTLLA WEITWNKQRK YYLGIEDRSD
PIHDLFAKAN YPFIKALMYD LNFTLNMLQV DSGGWKINGT FTGIMGKFQK RSIELGILGA
LMRSDRMEVV DYTIVTMIVK SSIIFKQPPL SLVSNIYELP FSTGVWFSCG GFVVFYWITL
VLFRLITKTE PFTVQESLYY MIGTICQQNV ELMPHFNSAK LMFFFAHLTS FFIFTSYSAS
IVALLQSPSR AITTVADLAA SPFKAGSMDA IYAFVYFNES KDPAVKELFQ KKMKPLGKKA
FTEADVGMRR VRDEFYAFSV EVNAAYLLIK ETFTPQDVCK VYELEAIKLP PFSIPVLKGS
KYRELLRQRL IWQREVGIIR RYNLIWIAQK PTCESGAAAF NSVGLNELRY VCIFMIIGFG
VAFLLLACEI AWKKQQNKRI SKAKLKQQQS RSTLISFLN
//
