ID B0WZV1_CULQU Unreviewed; 734 AA.
AC B0WZV1;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE SubName: Full=Kinase c-binding protein nell1 {ECO:0000313|EMBL:EDS37776.1};
GN Name=6045583 {ECO:0000313|EnsemblMetazoa:CPIJ012874-PA};
GN ORFNames=CpipJ_CPIJ012874 {ECO:0000313|EMBL:EDS37776.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS37776.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS37776.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ012874-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ012874-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; DS232218; EDS37776.1; -; Genomic_DNA.
DR RefSeq; XP_001862923.1; XM_001862888.1.
DR AlphaFoldDB; B0WZV1; -.
DR STRING; 7176.B0WZV1; -.
DR EnsemblMetazoa; CPIJ012874-RA; CPIJ012874-PA; CPIJ012874.
DR KEGG; cqu:CpipJ_CPIJ012874; -.
DR VEuPathDB; VectorBase:CPIJ012874; -.
DR VEuPathDB; VectorBase:CQUJHB018145; -.
DR eggNOG; KOG1217; Eukaryota.
DR HOGENOM; CLU_006887_0_0_1; -.
DR InParanoid; B0WZV1; -.
DR OMA; TCGQFLE; -.
DR OrthoDB; 5487at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 4.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 6.20.200.20; -; 3.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR048287; TSPN-like_N.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR24042:SF5; EGF_CA DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24042; NEL HOMOLOG; 1.
DR Pfam; PF12947; EGF_3; 2.
DR Pfam; PF07645; EGF_CA; 3.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF00093; VWC; 3.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00179; EGF_CA; 5.
DR SMART; SM00282; LamG; 1.
DR SMART; SM00210; TSPN; 1.
DR SMART; SM00214; VWC; 4.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57603; FnI-like domain; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 4.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS01208; VWFC_1; 3.
DR PROSITE; PS50184; VWFC_2; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Kinase {ECO:0000313|EMBL:EDS37776.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000313|EMBL:EDS37776.1}.
FT DOMAIN 199..255
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 256..314
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 315..354
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 355..400
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 401..441
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 442..472
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 474..514
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 622..682
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DISULFID 444..454
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 462..471
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 734 AA; 81397 MW; 9F7215B6EB40523D CRC64;
MKRTADFTFA VVLKQEQANS GTIVSFSNGN NRYLELQSSG RRDEIRFHYT HITAAGEPLM
RYESFPYRLA DDAEHKVALT VSGTEVQLYI DCHPLYKRVM HFLPDRNFSA SNMQLFVGQR
NSNSHYLFKG DLKDLRIITG PYGYLSQCEL MDAQCPTCGQ FLEYEKTLAK FQQSLLSLQV
QLVAAENRIT HLEKCDCKKS CLIDGTSKDD GDIWDIGCSQ CKCESGVVTC GPRPCPEVKC
KHPVLEKGAC CPKCLKNCYI NKKDYEHGDK QILGCRNCSC IDGNMLCDML QCPELKCPPE
QQLSVTDECC KFCQGVDYCS KGHACHTNAT CLNLNTKYTC TCRSGFHGDG YECSDIDECA
QQGGLNGNHC HLNTRCVNTF GSYVCECVAG YRRLDKFNCV EVDECKSGEH SCHEHADCSN
TAGSYHCRCQ PGYEGDGYDC KPVCNQTCLN GGECRAPGVC TCRAGYVGES CEKDLDECAT
GVHRCKETTN CVNMPGWYYC KCKPGFETKG KDCVDIDECY LNTHSCHPTA RCVNTQGHFE
LVATVAATVR SGAASNCRLS CMFEDSEIPD GGQISPRNQP CKVCTCSRGV ISCVEPPCNC
SRWQERGSGA RDLCCPQCDP KESCQHQELK HVTFRSGEQW IYQCQTCECL YGEFDCWRLE
CPPLTCDNPL PMGRGDCCPR CPDDMCGLEN ATATIGSGGS GASLPCLYEQ HIYASGQTFK
YPSRECATCS CKVS
//
