ID   B0X5A4_CULQU            Unreviewed;       293 AA.
AC   B0X5A4;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   27-MAR-2024, entry version 85.
DE   SubName: Full=Elastase-3A {ECO:0000313|EMBL:EDS40789.1};
GN   Name=6047826 {ECO:0000313|EnsemblMetazoa:CPIJ014523-PA};
GN   ORFNames=CpipJ_CPIJ014523 {ECO:0000313|EMBL:EDS40789.1};
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1] {ECO:0000313|EMBL:EDS40789.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB {ECO:0000313|EMBL:EDS40789.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA   Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:CPIJ014523-PA}
RP   IDENTIFICATION.
RC   STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ014523-PA};
RG   EnsemblMetazoa;
RL   Submitted (FEB-2021) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family. CLIP subfamily.
CC       {ECO:0000256|ARBA:ARBA00024195}.
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DR   EMBL; DS232373; EDS40789.1; -; Genomic_DNA.
DR   RefSeq; XP_001864826.1; XM_001864791.1.
DR   AlphaFoldDB; B0X5A4; -.
DR   STRING; 7176.B0X5A4; -.
DR   EnsemblMetazoa; CPIJ014523-RA; CPIJ014523-PA; CPIJ014523.
DR   GeneID; 6047826; -.
DR   KEGG; cqu:CpipJ_CPIJ014523; -.
DR   VEuPathDB; VectorBase:CPIJ014523; -.
DR   VEuPathDB; VectorBase:CQUJHB005458; -.
DR   eggNOG; KOG3627; Eukaryota.
DR   HOGENOM; CLU_006842_7_0_1; -.
DR   InParanoid; B0X5A4; -.
DR   OMA; NTAPLMG; -.
DR   OrthoDB; 3452965at2759; -.
DR   Proteomes; UP000002320; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR001254; Trypsin_dom.
DR   PANTHER; PTHR24250; CHYMOTRYPSIN-RELATED; 1.
DR   PANTHER; PTHR24250:SF65; PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..293
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5011408976"
FT   TRANSMEM        264..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          24..254
FT                   /note="Peptidase S1"
FT                   /evidence="ECO:0000259|PROSITE:PS50240"
SQ   SEQUENCE   293 AA;  31844 MW;  464123A9ABD3FE97 CRC64;
     MLPTAFLVGL LLTSTIATEK SARIFGGAQV QPGELPFNAL IELTKHDNSV RTSCGSVLSM
     QWILTSSSSV QQDSTRPGAF TVFAGKYDLL QREGSEQSRS VQRVLCHPEF DGSVEGQNDI
     ALLLLAKSLS FNDYVQPVAL ETNWMVYPTG VATISGYGSI RADGSKASYL TRWSVTIMAP
     EICIATLASS NLSLFCTDPA TCEGDWGAPL VQRRGDQWVQ IGLMSSGTQC VFFGPPTYYT
     HVARFFSWIN ETISTPVADE PDGAVRPVSG VLLIGALFTA TLYYLTHKQY ITQ
//