ID B0X7Y7_CULQU Unreviewed; 522 AA.
AC B0X7Y7;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=NEDD8-activating enzyme E1 regulatory subunit {ECO:0000256|ARBA:ARBA00015407, ECO:0000256|PIRNR:PIRNR039099};
GN Name=6048919 {ECO:0000313|EnsemblMetazoa:CPIJ015396-PA};
GN ORFNames=CpipJ_CPIJ015396 {ECO:0000313|EMBL:EDS42206.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS42206.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS42206.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ015396-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ015396-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein neddylation.
CC {ECO:0000256|ARBA:ARBA00005032, ECO:0000256|PIRNR:PIRNR039099}.
CC -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family. ULA1
CC subfamily. {ECO:0000256|ARBA:ARBA00006868,
CC ECO:0000256|PIRNR:PIRNR039099}.
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DR EMBL; DS232468; EDS42206.1; -; Genomic_DNA.
DR RefSeq; XP_001865759.1; XM_001865724.1.
DR AlphaFoldDB; B0X7Y7; -.
DR STRING; 7176.B0X7Y7; -.
DR EnsemblMetazoa; CPIJ015396-RA; CPIJ015396-PA; CPIJ015396.
DR GeneID; 6048919; -.
DR KEGG; cqu:CpipJ_CPIJ015396; -.
DR VEuPathDB; VectorBase:CPIJ015396; -.
DR VEuPathDB; VectorBase:CQUJHB010692; -.
DR eggNOG; KOG2016; Eukaryota.
DR HOGENOM; CLU_019618_2_1_1; -.
DR InParanoid; B0X7Y7; -.
DR OMA; TMEHSHI; -.
DR OrthoDB; 5488891at2759; -.
DR UniPathway; UPA00885; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0019781; F:NEDD8 activating enzyme activity; IEA:UniProtKB-UniRule.
DR GO; GO:0045116; P:protein neddylation; IEA:UniProtKB-UniRule.
DR CDD; cd01493; APPBP1_RUB; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR030667; APP-BP1.
DR InterPro; IPR045886; ThiF/MoeB/HesA.
DR InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR InterPro; IPR035985; Ubiquitin-activating_enz.
DR PANTHER; PTHR10953:SF29; NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR Pfam; PF00899; ThiF; 1.
DR PIRSF; PIRSF039099; APP-BP1; 1.
DR SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Ubl conjugation pathway {ECO:0000256|PIRNR:PIRNR039099}.
FT DOMAIN 18..521
FT /note="THIF-type NAD/FAD binding fold"
FT /evidence="ECO:0000259|Pfam:PF00899"
SQ SEQUENCE 522 AA; 58122 MW; 210F3C5FF66510A2 CRC64;
MSSPAPKSPE MSDKSRKYDR QIRLWGEHGQ TLLENAQICL INATALGTEI LKGVVLPGIG
GFTIVDSGLV TEEDIGCNFF LDSGSVGQSR ARSCMQLLQE LNPDVNGEYV DEAVDQLIDG
QPEFFKSFDV IVATAVSERT IVRLSNLLWD MHIPLLVCRS VGFYGVARLQ VKEHCIVESH
PDSHQSDLRL EHPFEALRKH MAETAITSKV PWLVVMYKCL EEWVSAHDGR YPANYKEKTE
LRDLIRSKMS ADEENHEEAI KAVNSSFGGG KPNSAIKEIL ADDCCINVNK ESNAFWILAR
ALRDFVENEG AGLLPLPGVL PDMTADTASY INLQNVYRSQ AAHDSEIVYR RARQLLKELN
KPNDLITEKD VRLFCREAAN IAIVRGTKIA VEYDKGYKAT QISTGLETPN SLMAHYVTLR
AVDKFQAEHG YLPGECQVEV DTSRIKGLAA KMVSEWGIST PISDDLAHEV CRYGGAEIHS
ISAFFGGCIA HELIKLVTRQ YKPFDNTFVY DGATSQTETF KL
//
