ID B0X8H8_CULQU Unreviewed; 1310 AA.
AC B0X8H8;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE RecName: Full=Cation-transporting ATPase {ECO:0000256|RuleBase:RU362082};
DE EC=7.2.2.- {ECO:0000256|RuleBase:RU362082};
GN Name=6049144 {ECO:0000313|EnsemblMetazoa:CPIJ015651-PA};
GN ORFNames=CpipJ_CPIJ015651 {ECO:0000313|EMBL:EDS42514.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS42514.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS42514.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ015651-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ015651-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|RuleBase:RU362082};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362082}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362082}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type V subfamily. {ECO:0000256|ARBA:ARBA00006000,
CC ECO:0000256|RuleBase:RU362082}.
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DR EMBL; DS232489; EDS42514.1; -; Genomic_DNA.
DR RefSeq; XP_001865950.1; XM_001865915.1.
DR STRING; 7176.B0X8H8; -.
DR EnsemblMetazoa; CPIJ015651-RA; CPIJ015651-PA; CPIJ015651.
DR GeneID; 6049144; -.
DR KEGG; cqu:CpipJ_CPIJ015651; -.
DR VEuPathDB; VectorBase:CPIJ015651; -.
DR VEuPathDB; VectorBase:CQUJHB014172; -.
DR eggNOG; KOG0208; Eukaryota.
DR HOGENOM; CLU_001828_0_0_1; -.
DR InParanoid; B0X8H8; -.
DR OMA; KLRYRWH; -.
DR OrthoDB; 6047at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0019829; F:ATPase-coupled monoatomic cation transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0015662; F:P-type ion transporter activity; IEA:InterPro.
DR CDD; cd07542; P-type_ATPase_cation; 1.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR006544; P-type_TPase_V.
DR InterPro; IPR047819; P5A-ATPase_N.
DR InterPro; IPR047821; P5B-type_ATPase.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01494; ATPase_P-type; 3.
DR NCBIfam; TIGR01657; P-ATPase-V; 1.
DR PANTHER; PTHR45630:SF8; CATION-TRANSPORTING ATPASE; 1.
DR PANTHER; PTHR45630; CATION-TRANSPORTING ATPASE-RELATED; 1.
DR Pfam; PF13246; Cation_ATPase; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF12409; P5-ATPase; 1.
DR PRINTS; PR00119; CATATPASE.
DR SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU362082};
KW Magnesium {ECO:0000256|RuleBase:RU362082};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362082};
KW Metal-binding {ECO:0000256|RuleBase:RU362082};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU362082};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Translocase {ECO:0000256|ARBA:ARBA00022967, ECO:0000256|RuleBase:RU362082};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362082};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362082}.
FT TRANSMEM 93..112
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 282..304
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 310..330
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 481..499
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 519..539
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 1042..1066
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 1078..1094
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 1115..1139
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 1165..1183
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 1195..1215
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 1235..1258
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT DOMAIN 79..231
FT /note="P5B-type ATPase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12409"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..26
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1310 AA; 147084 MW; DEAF8A0AA0B39C84 CRC64;
MPLETSDLHP EPVPPAHPPP PPDVPDQANG GYKSQMAAAI RSSNRRVEEK HHPEGHSTLV
ELLTETSQAS VHDILNDGEE DQMFVTGYEK SSVRTFFCYV GFALTLGIMR LVMHWWQHWL
LLATHRKCSL EVAQKVLVHE RYQDKHDAYY VKNVITMNAE AISEVTSTSK RLSTNGQCIV
KELQQNGITN RVAFFNECNP FQVAFHRTGG RFEHFDSIRF FCCKKLRYIW SPETKQFVKL
RGMDVDVPSV TIHHNKGLST YEQNIRRLVY GSNEILIPLR GVVTLLFLEV LNPFYVFQIF
SVILWFAYDY YYYATVIMLM SGFGITVSII QTQKNQKALY STVKSSDTAT VIRENCESEQ
IETRLLVPGD VLEIPATGCT MQCDAVLISG NCILDESMLT GESVPVTKTP LPLKRDLNYD
NKEHARHTLF CGTKVIQTRY IGSEKVLVKV INTGNITAKG GLIRSILYPP PVDYKFEKDS
YKFIMVLAFL AGCGFLYTVT TKILRGVGAL KIIVESLDLI TIAVPPALPA AMTVGRMYAQ
KRLQKNNIYC VSPRAINVSG SIDCVCFDKT GTLTEDGLDM WGVLPKDSTN NFQIPLTQIN
RLPMSEHLLS GMLTCHSITF VNGEMRGDPL DLKIFESTGW ILEEANVSDE TKYDLLFPTI
VKPPRTDSKD NLNLELDVAY DNSNDIGIVR EFSFTSALQR MSVITRKLSD NHFNVYCKGS
PEMISSLCKP ESIPEDFTNK LGFYAQQGYR IIAIAYKSLD KKMNYSKVQK VSREKIESDL
QFLGFVILEN RLKTDTEEVI ESLNAANIRC IMVTGDNLLT AASVAHDCGM VMPGQSLVTV
TAHVDKSGSN KYFLSYDITG QPQLTQSDII NDNSVSDEKR NGNYTLMTQS NSVSSCETID
TCTLSTQVSA FEKEAHRITI EGEGEKTIAA GKGGSFRFAL TGKTWAIIKE HFVDLVPTII
TFGTVFARMS PDQKQHLISD LQNLGYYVAM CGDGANDCGA LKAAHTGISL SEAESSVASP
FTSKNPTIAC VPKVIKEGRA ALVTSFGIFK YMAAYSLVQF ASVLILYSID SNLTDLEFLY
IDLFIISVTA FFFGKTSSYD GPLVKQTPSN SLISLSPLLS LALHLIVALG FQVAGWYHIQ
AQPWFVPFNY TDELALNDLG CYENYAVFCI STFQYIILAI VFSKGAPYRK SIISNYGFLV
AIIFNTCLSI LLTLYPPVWL QDLFQLVIPQ DDMIFRAYLV GYGVANFILA LFIEKYIIDE
IAFKKLRYRW HNIAKSRRKY LMIEHSFRKE VQHPSDFKTV LGWSSEKYDY
//
