ID B1H2S4_XENTR Unreviewed; 703 AA.
AC B1H2S4;
DT 29-APR-2008, integrated into UniProtKB/TrEMBL.
DT 29-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=LOC100145475 protein {ECO:0000313|EMBL:AAI61110.1};
DE SubName: Full=Protein-glutamine gamma-glutamyltransferase E {ECO:0000313|RefSeq:NP_001120399.1};
DE EC=2.3.2.13 {ECO:0000313|RefSeq:NP_001120399.1};
GN Name=tgm6 {ECO:0000313|RefSeq:NP_001120399.1,
GN ECO:0000313|Xenbase:XB-GENE-5878274};
GN Synonyms=LOC100145475 {ECO:0000313|EMBL:AAI61110.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI61110.1};
RN [1] {ECO:0000313|RefSeq:NP_001120399.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAI61110.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testes {ECO:0000313|EMBL:AAI61110.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001120399.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the transglutaminase superfamily.
CC Transglutaminase family. {ECO:0000256|ARBA:ARBA00005968}.
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DR EMBL; BC161110; AAI61110.1; -; mRNA.
DR RefSeq; NP_001120399.1; NM_001126927.1.
DR GeneID; 100145475; -.
DR KEGG; xtr:100145475; -.
DR AGR; Xenbase:XB-GENE-5878274; -.
DR CTD; 343641; -.
DR Xenbase; XB-GENE-5878274; tgm6.
DR OMA; IRMTALC; -.
DR OrthoDB; 5344745at2759; -.
DR Proteomes; UP000008143; Chromosome 10.
DR GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR002931; Transglutaminase-like.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR InterPro; IPR023608; Transglutaminase_animal.
DR InterPro; IPR008958; Transglutaminase_C.
DR InterPro; IPR036238; Transglutaminase_C_sf.
DR InterPro; IPR001102; Transglutaminase_N.
DR PANTHER; PTHR11590; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE; 1.
DR PANTHER; PTHR11590:SF36; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE E; 1.
DR Pfam; PF00927; Transglut_C; 2.
DR Pfam; PF01841; Transglut_core; 1.
DR Pfam; PF00868; Transglut_N; 1.
DR PIRSF; PIRSF000459; TGM_EBP42; 1.
DR SMART; SM00460; TGc; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49309; Transglutaminase, two C-terminal domains; 2.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000008143}.
FT DOMAIN 269..361
FT /note="Transglutaminase-like"
FT /evidence="ECO:0000259|SMART:SM00460"
FT ACT_SITE 277
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT ACT_SITE 335
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT ACT_SITE 358
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
SQ SEQUENCE 703 AA; 79333 MW; B921C708630F292C CRC64;
MRSDPQVIAC DWYYAVNEKA HHTDVYESDD LVLRRGQPFK LTLMLNRPLQ AEENILFIFE
TGPSPSETSK TKVVFPLFRA ENLQSWGAIL TSIKSTSITV TINSHSDAVI GRYILSVAVQ
CRGSDKPLPH QIGALNLLFN PWLQGDAVFM AEEDQRQEYV MNEQGVIFQG SDEDITSINW
EYNQFERNIL DICLVILDRS QNYKKDPALD VSQRNDPLYV CRVLSAMLNS KGDDGVLEEN
WSDDYINGAS PSSWNGSMNI LKSWYYSKFK PVKYGQCWVY AGMLCTVLRS LGIPTRVITH
FNSGQDKNAN LFIDLQYKSQ GSRQNDQEDQ LWNFHVWNEA YFKRRDLGKS YNGWQVIDST
PLKRSDGVYQ CGPAPLTAIK EGDINLNYDV KYMFASVNAD VACWIYYRNG TKKQVSNNAK
ETGKFISTKA IGSNDRVDVT NNYKYAKGSE KEIKVFEKAL KLSKGSFVGR TREKPRGGNI
LFGRCTLDQI ATFGQDFNLI LSLKNLTPDS INVTVYINTS AILYTGRQRH TIWTGGKFLS
LGPNLEKRFS IPVKYGQYSK HMTDNGVICM TALCEVEGTE ERILVERNVS LVKPPLSITL
PDKAIINQES NANIVIVNPL LETLNSCILW VEGYGLTDKI LKKEVPSLKP GQSSEHNFVI
TPMKTGVRTL LVNFSCDKIQ NMKGSGKILI TYSQEVSDSP VPT
//
