ID B1L191_CLOBM Unreviewed; 380 AA.
AC B1L191;
DT 29-APR-2008, integrated into UniProtKB/TrEMBL.
DT 29-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Methyltransferase {ECO:0000313|EMBL:ACA55591.1};
GN OrderedLocusNames=CLK_0962 {ECO:0000313|EMBL:ACA55591.1};
OS Clostridium botulinum (strain Loch Maree / Type A3).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=498214 {ECO:0000313|EMBL:ACA55591.1, ECO:0000313|Proteomes:UP000000722};
RN [1] {ECO:0000313|EMBL:ACA55591.1, ECO:0000313|Proteomes:UP000000722}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Loch Maree / Type A3 {ECO:0000313|Proteomes:UP000000722};
RX PubMed=18060065; DOI=10.1371/journal.pone.0001271;
RA Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C.,
RA Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.;
RT "Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4
RT and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within
RT plasmids.";
RL PLoS ONE 2:E1271-E1271(2007).
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DR EMBL; CP000962; ACA55591.1; -; Genomic_DNA.
DR RefSeq; WP_012343552.1; NC_010520.1.
DR AlphaFoldDB; B1L191; -.
DR KEGG; cbl:CLK_0962; -.
DR HOGENOM; CLU_032119_3_1_9; -.
DR Proteomes; UP000000722; Chromosome.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0034470; P:ncRNA processing; IEA:UniProt.
DR GO; GO:0009451; P:RNA modification; IEA:UniProt.
DR CDD; cd11715; THUMP_AdoMetMT; 1.
DR Gene3D; 3.30.2130.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR000241; RlmKL-like_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR004114; THUMP_dom.
DR PANTHER; PTHR47313; RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE K/L; 1.
DR PANTHER; PTHR47313:SF1; RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE K_L; 1.
DR Pfam; PF02926; THUMP; 1.
DR Pfam; PF01170; UPF0020; 1.
DR SMART; SM00981; THUMP; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
DR PROSITE; PS51165; THUMP; 1.
DR PROSITE; PS01261; UPF0020; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:ACA55591.1};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00529};
KW Transferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000313|EMBL:ACA55591.1}.
FT DOMAIN 44..154
FT /note="THUMP"
FT /evidence="ECO:0000259|PROSITE:PS51165"
SQ SEQUENCE 380 AA; 43232 MW; E52FA4761B16EC94 CRC64;
MEYTLIATAT FGLEKVVANE LKELGYDDLT IENGKVTFVG DERDIVTCNM WLRTADRVLI
KMAEFKAESF EELFQGTKSV PWGKYISEDG FMHVTGKSIK SALHSVPDCQ SIVKKAVIEA
MKREYVKDWF SEDGAEYKIE VAILKDIVIL TLDTSGPGLH KRGYRENAGE APLKETLAAA
LVLLSKWEPS RILSDPMCGS GTIAIEAALI GKNIAPGLNR SFAAESWDII PLNMWEEVRR
HARKSINKED FRILASDING KILKTARDNA QKSGVSDYIA FQKMSMEEFK SKKKYGFIIT
NPPYGERLNT LKEVEKLYKN LGEVYSNLQD WSCFILTSYE GFEKIFGKKS DKNRKLYNGR
LKCYYYQYIG LEPPKKCYEK
//
