ID B1M9D0_METRJ Unreviewed; 1191 AA.
AC B1M9D0;
DT 29-APR-2008, integrated into UniProtKB/TrEMBL.
DT 29-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=Blue-light-activated histidine kinase {ECO:0000256|ARBA:ARBA00021740};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN OrderedLocusNames=Mrad2831_6181 {ECO:0000313|EMBL:ACB28105.1};
OS Methylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831 /
OS NBRC 15690 / NCIMB 10815 / 0-1).
OG Plasmid pMRAD01 {ECO:0000313|EMBL:ACB28105.1,
OG ECO:0000313|Proteomes:UP000006589}.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Methylobacteriaceae; Methylobacterium.
OX NCBI_TaxID=426355 {ECO:0000313|EMBL:ACB28105.1, ECO:0000313|Proteomes:UP000006589};
RN [1] {ECO:0000313|EMBL:ACB28105.1, ECO:0000313|Proteomes:UP000006589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27329 / DSM 1819 / JCM 2831 / NBRC 15690 / NCIMB 10815 /
RC 0-1 {ECO:0000313|Proteomes:UP000006589};
RC PLASMID=Plasmid pMRAD01 {ECO:0000313|Proteomes:UP000006589};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C.,
RA Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Mikhailova N., Marx C.J., Richardson P.;
RT "Complete sequence of plasmid1 of Methylobacterium radiotolerans JCM
RT 2831.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CP001002; ACB28105.1; -; Genomic_DNA.
DR AlphaFoldDB; B1M9D0; -.
DR KEGG; mrd:Mrad2831_6181; -.
DR eggNOG; COG2203; Bacteria.
DR eggNOG; COG2205; Bacteria.
DR eggNOG; COG3920; Bacteria.
DR eggNOG; COG5000; Bacteria.
DR HOGENOM; CLU_007893_0_0_5; -.
DR OrthoDB; 341208at2; -.
DR Proteomes; UP000006589; Plasmid pMRAD01.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004673; F:protein histidine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd00130; PAS; 3.
DR Gene3D; 2.10.70.100; -; 1.
DR Gene3D; 3.30.450.40; -; 2.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 5.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR013655; PAS_fold_3.
DR InterPro; IPR011102; Sig_transdc_His_kinase_HWE.
DR NCBIfam; TIGR00229; sensory_box; 4.
DR PANTHER; PTHR41523:SF7; ETHYLENE RESPONSE SENSOR PROTEIN; 1.
DR PANTHER; PTHR41523; TWO-COMPONENT SYSTEM SENSOR PROTEIN; 1.
DR Pfam; PF01590; GAF; 1.
DR Pfam; PF13185; GAF_2; 1.
DR Pfam; PF07536; HWE_HK; 1.
DR Pfam; PF08447; PAS_3; 1.
DR Pfam; PF08448; PAS_4; 2.
DR Pfam; PF13426; PAS_9; 2.
DR SMART; SM00065; GAF; 2.
DR SMART; SM00911; HWE_HK; 1.
DR SMART; SM00086; PAC; 5.
DR SMART; SM00091; PAS; 4.
DR SUPFAM; SSF55781; GAF domain-like; 2.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 5.
DR PROSITE; PS50113; PAC; 5.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW FMN {ECO:0000256|ARBA:ARBA00022643};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ACB28105.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Plasmid {ECO:0000313|EMBL:ACB28105.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT DOMAIN 343..416
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 417..470
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 471..543
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 547..599
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 686..739
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 809..862
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 943..995
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
SQ SEQUENCE 1191 AA; 129653 MW; E0C5E49592BE2A38 CRC64;
MNQVMPVARI EEDARLLALA AFGILDTPPE RGFDDIVHLA RQLCAAPVAL ISLLDRDRQW
FKARAGFPPC ETDLDRSVCK FVLAETGVLQ IPDLTLDPRT LGNPLVTGEP HLRFYAGAPL
RSPGGEVLGS LCVIDHAPRP GGLTPAQVEN LERLARQVVD QLVLRRALAE RDRGERQRTA
IAETLAAVVA TGGDLDASFR AVLAGAMRAV PAAEAGAVEM RDGDDLVYRA VTADLTPHLG
LRFPVQGSLA GACLREGIPL LLPDVLRDPR AKRDVLESSR LRSCLLVPVR RGGTMVGVLK
LQSSRPAAFS EDDLKAATVF AATVATGLAE AGEVAARSEA SRTEYRRRAV FDSAHDYAII
VLDLEGRVTD WNSGATRILG WRSEEMCGKP ADAFFTPEDR RDGIPDKEMR SAMENGRGID
ERWHLRRDGE RFWANGEMMA LRDEDGAAIG FVKILRDRTE QKEAVARLEE SRERYRLVAR
ATNDAIWDWD LATNHVLWNE ALNEAYGHAS GAVEPTGEWW IAHIHPEDRA RIDSAIRAVI
DGAGTAWTEE YRFLRADGSY AHVLDRGYVI RDAEGRARRM IGAMLDLSER KQAEDALRES
ERRFALERGL LHAVFQQAPV GISIAGATAE VPSVINARAE ELLGHGLGTE GDARYVSYGA
QHPDGRRYEP GDYPTLRALR HGETVRAEEM HYRNAATGLV RPLEVSSGPV RDADGTIQAA
VTVLVDVEDQ RRAEAEARKL AALVEQSRDF IGLAAPDGTV DFVNEAGRRL VGLPDLAART
NRILDYFVPG EHDRILADVL PAAERDGFWE GELHFRNFAT GAGVPVHYNI FQVRDRNGEL
LGYGTVTRDL TEQHRARQAL QASEASLRAV LDTVPVGILF AEAPSGRIVG GNRRLEEIFR
HPVLPSPNAE SYGEWVAFHE DGRRVEPNEY PLSRIIREGA EHAALECHYQ RGDGTRVWIE
IVGVPMRDES GTIVGAVVAV ADIDARHRAE ERQDLLNQEL SHRMKNLLAM VQAIAASTLR
GAADMDTARE VLGSRLVALG KAHDVLLGGA AESASLAAVV REGVGVQESA GRRVAFVGPD
VEIGGKAVLS LALTLHELTT NAVKYGALSV PDGTVTVEAA LVGPAAAPRL RIAWTERGGP
PVVPPARKGF GSRLIERGLT AQVSASLALD YRPEGVSCVI EAALTDFQAT G
//
