ID B1MKU4_MYCA9 Unreviewed; 391 AA.
AC B1MKU4;
DT 29-APR-2008, integrated into UniProtKB/TrEMBL.
DT 29-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Two-component system sensor kinase {ECO:0000313|EMBL:CAM64589.1};
GN OrderedLocusNames=MAB_4520c {ECO:0000313|EMBL:CAM64589.1};
OS Mycobacteroides abscessus (strain ATCC 19977 / DSM 44196 / CCUG 20993 / CIP
OS 104536 / JCM 13569 / NCTC 13031 / TMC 1543 / L948) (Mycobacterium
OS abscessus).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacteroides; Mycobacteroides abscessus.
OX NCBI_TaxID=561007 {ECO:0000313|EMBL:CAM64589.1, ECO:0000313|Proteomes:UP000007137};
RN [1] {ECO:0000313|EMBL:CAM64589.1, ECO:0000313|Proteomes:UP000007137}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 /
RC TMC 1543 {ECO:0000313|Proteomes:UP000007137};
RX PubMed=19543527; DOI=10.1371/journal.pone.0005660;
RA Ripoll F., Pasek S., Schenowitz C., Dossat C., Barbe V., Rottman M.,
RA Macheras E., Heym B., Herrmann J.L., Daffe M., Brosch R., Risler J.L.,
RA Gaillard J.L.;
RT "Non mycobacterial virulence genes in the genome of the emerging pathogen
RT Mycobacterium abscessus.";
RL PLoS ONE 4:E5660-E5660(2009).
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DR EMBL; CU458896; CAM64589.1; -; Genomic_DNA.
DR RefSeq; WP_005079827.1; NZ_MLCG01000001.1.
DR AlphaFoldDB; B1MKU4; -.
DR GeneID; 66969951; -.
DR KEGG; mab:MAB_4520c; -.
DR Proteomes; UP000007137; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR045975; DUF5931.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR PANTHER; PTHR24421; NITRATE/NITRITE SENSOR PROTEIN NARX-RELATED; 1.
DR PANTHER; PTHR24421:SF65; SENSOR HISTIDINE KINASE COMP; 1.
DR Pfam; PF19354; DUF5931; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:CAM64589.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Transferase {ECO:0000313|EMBL:CAM64589.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 55..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 80..101
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 121..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 20..173
FT /note="DUF5931"
FT /evidence="ECO:0000259|Pfam:PF19354"
FT DOMAIN 292..386
FT /note="Histidine kinase/HSP90-like ATPase"
FT /evidence="ECO:0000259|Pfam:PF02518"
SQ SEQUENCE 391 AA; 41398 MW; 2FD9A221EA79236D CRC64;
MGSKNGTVPR WMSGSDPTAS LWRAAQVFRL ASFGYALLAS QLASYTNYER QGLSWALYAV
MAMWTGFAAV ALSRNWFRRW QLVLCDQAIV IALMLAGRLV VDVQWYSGHQ TLPTTLWVAN
AVVSMGLLRG QLAGVISGFV LAAVSIAARG LPVSALWLDA TMPALVVVGL AIGAASTTAK
RTFHELRRAE RAAAAAIERE RLSRQVHDGV LQVLSYVKRR GTEIGGPTAE LAAIAGEQEI
ALRELISGAT QTTLADDELV DLRPLLRTQA STTVSVSAPG APVLIGQHMA SELAAVVRSA
LSNVALHAGP QAHAYVLIED LVDSVVVTVR DDGSGIADGR LDQAEREGRM GVSRSILGRV
ADLGGAVLLE TGPGAGTEWE ITVPKSQEVG A
//
