ID B1MPF0_MYCA9 Unreviewed; 441 AA.
AC B1MPF0;
DT 29-APR-2008, integrated into UniProtKB/TrEMBL.
DT 29-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=Polyketide synthase MbtC {ECO:0000313|EMBL:CAM62201.1};
GN OrderedLocusNames=MAB_2120c {ECO:0000313|EMBL:CAM62201.1};
OS Mycobacteroides abscessus (strain ATCC 19977 / DSM 44196 / CCUG 20993 / CIP
OS 104536 / JCM 13569 / NCTC 13031 / TMC 1543 / L948) (Mycobacterium
OS abscessus).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacteroides; Mycobacteroides abscessus.
OX NCBI_TaxID=561007 {ECO:0000313|EMBL:CAM62201.1, ECO:0000313|Proteomes:UP000007137};
RN [1] {ECO:0000313|EMBL:CAM62201.1, ECO:0000313|Proteomes:UP000007137}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 /
RC TMC 1543 {ECO:0000313|Proteomes:UP000007137};
RX PubMed=19543527; DOI=10.1371/journal.pone.0005660;
RA Ripoll F., Pasek S., Schenowitz C., Dossat C., Barbe V., Rottman M.,
RA Macheras E., Heym B., Herrmann J.L., Daffe M., Brosch R., Risler J.L.,
RA Gaillard J.L.;
RT "Non mycobacterial virulence genes in the genome of the emerging pathogen
RT Mycobacterium abscessus.";
RL PLoS ONE 4:E5660-E5660(2009).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|RuleBase:RU003694}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CU458896; CAM62201.1; -; Genomic_DNA.
DR RefSeq; WP_005080165.1; NZ_MLCG01000002.1.
DR AlphaFoldDB; B1MPF0; -.
DR GeneID; 66972491; -.
DR KEGG; mab:MAB_2120c; -.
DR Proteomes; UP000007137; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Transferase {ECO:0000256|RuleBase:RU003694}.
FT DOMAIN 6..428
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 441 AA; 45462 MW; 8267FD32E60BD978 CRC64;
MTAVHVDPVV ISGMAIEAPG GIDTPAAFWN ALADGRELIS AFPRDRGWPV DELLSLSNLD
GWGRISDAGG FITDASAFDP TFYGITQREA VAMDPQQRVA MRVAWKALEN TGLNPGAVDG
SEAGCFIGIS PNEYGPPVGE VNAHSGMRVV GRGQLGAAGR ISHGLGLIGP SVCVDSACAS
SLAALHLAAS AVRADECEWA IAGGVCVMGS PGGFYEFSRM HALDPDGHCR SYSDEANGTL
WGEAVGMVVL ERESRARALG HRVYGRIMAV RTNHNGGGKP ILVPRGRAQA KLVAATIAAS
GVDPADVGML EGHGTGTRAG DPLEILALQS TYGAGGSNAL LGSAKSNAGH AQSAAGMVGL
IKLLLSGQHG HIPPTLFADN PTTKIDWSMT GIRLATKLHP WEPKDGIRYG SVSSFGAGGA
NAHAIIAMPA MDAQGEDGDD F
//
