ID   B1N0U8_9ORTO            Unreviewed;       708 AA.
AC   B1N0U8;
DT   29-APR-2008, integrated into UniProtKB/TrEMBL.
DT   29-APR-2008, sequence version 1.
DT   14-DEC-2022, entry version 48.
DE   RecName: Full=RNA-directed RNA polymerase catalytic subunit {ECO:0000256|ARBA:ARBA00020035, ECO:0000256|RuleBase:RU004330};
DE            EC=2.7.7.48 {ECO:0000256|ARBA:ARBA00012494, ECO:0000256|RuleBase:RU004330};
GN   Name=PB1 {ECO:0000313|EMBL:ABG65767.1};
OS   Isavirus salaris.
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Insthoviricetes; Articulavirales; Orthomyxoviridae; Isavirus.
OX   NCBI_TaxID=55987 {ECO:0000313|EMBL:ABG65767.1};
RN   [1] {ECO:0000313|EMBL:ABG65767.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Vir28 {ECO:0000313|EMBL:ABG65767.1};
RX   PubMed=18280528; DOI=10.1016/j.virol.2008.01.019;
RA   Markussen T., Jonassen C.M., Numanovic S., Braaen S., Hjortaas M.,
RA   Nilsen H., Mjaaland S.;
RT   "Evolutionary mechanisms involved in the virulence of infectious salmon
RT   anaemia virus (ISAV), a piscine orthomyxovirus.";
RL   Virology 374:515-527(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48; Evidence={ECO:0000256|RuleBase:RU004330};
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DR   EMBL; DQ785201; ABG65767.1; -; Viral_cRNA.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR   InterPro; IPR007099; RNA-dir_pol_NSvirus.
DR   InterPro; IPR001407; RNA_pol_PB1_influenza.
DR   Pfam; PF00602; Flu_PB1; 1.
DR   PIRSF; PIRSF000827; RdRPol_OMV; 1.
DR   PROSITE; PS50525; RDRP_SSRNA_NEG_SEG; 1.
PE   4: Predicted;
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW   ECO:0000256|RuleBase:RU004330};
KW   Transferase {ECO:0000256|ARBA:ARBA00022695};
KW   Viral RNA replication {ECO:0000256|ARBA:ARBA00022953}.
FT   DOMAIN          281..467
FT                   /note="RdRp catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50525"
SQ   SEQUENCE   708 AA;  80473 MW;  415559934C6FB4C2 CRC64;
     METLVGGLLT GEDSLVSMSN DVSCLYVYDG PMRVFSQNAL MPTLQSVKRS DQFSKGKTKR
     FIIDLFGMKR MWDIGNKHLE DENLDETVGV ADLGLVKYLI NNKYDEAEKT SLRKSMEEAF
     EKSMNEEFVV LNKGKSANDI ISDTNAMCKF CVKNWIVATG FRGRTMSDLI EHHFRCMQGK
     QEVKGYIWKH KYNERLKRKQ LSKEEVKFDR EEYTSRSFRL LSFLKNSERT KLEPRAVFTA
     GVPWRAFIFV LEQTMLVVNK LDPNSVIWMG SDAKINTTNS RIKEIGMKNQ GQTLVTLTGD
     NSKYNESMCP EVMMIFLREL GIKGPMLEVL DYALWQFSQK SVKPVAPIKK RTSRSTVVVK
     ADAVNECRDA FNEKELELIQ GVEWMEDGFI RVRRGMLMGM ANNAFTTAST IASSFSFTPE
     AVYTLQSSDD FVTGSCGRDV QHARQRLEMA LKVSKAAGLN VSQKKSFYVG GTTFEFNSMF
     VRDGKVMANG GNFENITVPG GLGPSTDLFV VGKQARNSML RGNLSFSQAM EMCKIGITNV
     EKVYYGNRKY QELKNEIREK CGEETMSIPE SMGGDRKPKP WELPQSFDGI ALKEAVNRGH
     WKAAKYIKSC CSIEFDEEGD QSWDTSKTAL VVIRKNETDM RRRTVKTRNP KDKIFNDAMN
     KAKRMYETVV DRNPLLGLKG KGGRLTVKDL KARKLIDEVE VIKKKKHV
//