ID B1NX69_SALEN Unreviewed; 286 AA.
AC B1NX69;
DT 29-APR-2008, integrated into UniProtKB/TrEMBL.
DT 29-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Beta-lactamase {ECO:0000256|ARBA:ARBA00012865, ECO:0000256|RuleBase:RU361140};
DE EC=3.5.2.6 {ECO:0000256|ARBA:ARBA00012865, ECO:0000256|RuleBase:RU361140};
GN Name=blaSHV-12 {ECO:0000313|EMBL:ABX46814.1};
GN ORFNames=GI657_24225 {ECO:0000313|EMBL:HAB1337925.1}, GI657_24430
GN {ECO:0000313|EMBL:HAB1337956.1}, GJG03_24300
GN {ECO:0000313|EMBL:HAB3142190.1}, GJG03_24515
GN {ECO:0000313|EMBL:HAB3142221.1};
OS Salmonella enteritidis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=149539 {ECO:0000313|EMBL:ABX46814.1};
RN [1] {ECO:0000313|EMBL:ABX46814.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=2068/8 {ECO:0000313|EMBL:ABX46814.1};
RX PubMed=18063489; DOI=10.1016/j.vetmic.2007.10.016;
RA Chiaretto G., Zavagnin P., Bettini F., Mancin M., Minorello C.,
RA Saccardin C., Ricci A.;
RT "Extended spectrum beta-lactamase SHV-12-producing Salmonella from
RT poultry.";
RL Vet. Microbiol. 128:406-413(2008).
RN [2] {ECO:0000313|EMBL:HAB1337925.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ILBSalm5516340 {ECO:0000313|EMBL:HAB1337925.1}, and
RC ILBSalm5516341 {ECO:0000313|EMBL:HAB3142190.1};
RX PubMed=30286803;
RA Souvorov A., Agarwala R., Lipman D.J.;
RT "SKESA: strategic k-mer extension for scrupulous assemblies.";
RL Genome Biol. 19:153-153(2018).
RN [3] {ECO:0000313|EMBL:HAB1337925.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ILBSalm5516340 {ECO:0000313|EMBL:HAB1337925.1}, and
RC ILBSalm5516341 {ECO:0000313|EMBL:HAB3142190.1};
RG NCBI Pathogen Detection Project;
RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC ChEBI:CHEBI:140347; EC=3.5.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00001526,
CC ECO:0000256|RuleBase:RU361140};
CC -!- SIMILARITY: Belongs to the class-A beta-lactamase family.
CC {ECO:0000256|ARBA:ARBA00009009, ECO:0000256|RuleBase:RU361140}.
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DR EMBL; EU137696; ABX46814.1; -; Genomic_DNA.
DR EMBL; DAAFSM010000036; HAB1337925.1; -; Genomic_DNA.
DR EMBL; DAAFSM010000055; HAB1337956.1; -; Genomic_DNA.
DR EMBL; DAAGHY010000044; HAB3142190.1; -; Genomic_DNA.
DR EMBL; DAAGHY010000066; HAB3142221.1; -; Genomic_DNA.
DR AlphaFoldDB; B1NX69; -.
DR SMR; B1NX69; -.
DR GO; GO:0008800; F:beta-lactamase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030655; P:beta-lactam antibiotic catabolic process; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR045155; Beta-lactam_cat.
DR InterPro; IPR000871; Beta-lactam_class-A.
DR InterPro; IPR023650; Beta-lactam_class-A_AS.
DR PANTHER; PTHR35333; BETA-LACTAMASE; 1.
DR PANTHER; PTHR35333:SF3; BETA-LACTAMASE2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13354; Beta-lactamase2; 1.
DR PRINTS; PR00118; BLACTAMASEA.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR PROSITE; PS00146; BETA_LACTAMASE_A; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251,
KW ECO:0000256|RuleBase:RU361140};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361140};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..286
FT /note="Beta-lactamase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5033693422"
FT DOMAIN 45..258
FT /note="Beta-lactamase class A catalytic"
FT /evidence="ECO:0000259|Pfam:PF13354"
SQ SEQUENCE 286 AA; 31268 MW; 49BF42671C1F5FBD CRC64;
MRYIRLCIIS LLATLPLAVH ASPQPLEQIK QSESQLSGRV GMIEMDLASG RTLTAWRADE
RFPMMSTFKV VLCGAVLARV DAGDEQLERK IHYRQQDLVD YSPVSEKHLA DGMTVGELCA
AAITMSDNSA ANLLLATVGG PAGLTAFLRQ IGDNVTRLDR WETELNEALP GDARDTTTPA
SMAATLRKLL TSQRLSARSQ RQLLQWMVDD RVAGPLIRSV LPAGWFIADK TGASKRGARG
IVALLGPNNK AERIVVIYLR DTPASMAERN QQIAGIGAAL IEHWQR
//