ID B1PGA8_DROME Unreviewed; 254 AA.
AC B1PGA8;
DT 29-APR-2008, integrated into UniProtKB/TrEMBL.
DT 29-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=HERC2 {ECO:0000313|EMBL:ACA62135.1};
DE Flags: Fragment;
GN Name=HERC2 {ECO:0000313|EMBL:ACA62135.1};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:ACA62135.1};
RN [1] {ECO:0000313|EMBL:ACA62135.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18245821; DOI=10.1534/genetics.107.085423;
RA Levine M.T., Begun D.J.;
RT "Evidence of spatially varying selection acting on four chromatin-
RT remodeling loci in Drosophila melanogaster.";
RL Genetics 179:475-485(2008).
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DR EMBL; EU415450; ACA62135.1; -; Genomic_DNA.
DR AlphaFoldDB; B1PGA8; -.
DR VEuPathDB; VectorBase:FBgn0003557; -.
DR HOGENOM; CLU_000101_0_0_1; -.
DR ExpressionAtlas; B1PGA8; baseline and differential.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:UniProt.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR042469; HECTD3.
DR PANTHER; PTHR46654; E3 UBIQUITIN-PROTEIN LIGASE HECTD3; 1.
DR PANTHER; PTHR46654:SF1; E3 UBIQUITIN-PROTEIN LIGASE HECTD3; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 1..224
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 233..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 192
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACA62135.1"
SQ SEQUENCE 254 AA; 28798 MW; 98DA86E602CB7B37 CRC64;
TDLTEVDRDY VAGLLCIRNM DDDPKLFTAL ELPFSTSSAR GHEVPLSTRY THISPRNRAE
YVRLALGFRL HEFDEQVKAV RDGMSKVIPV PLLSLFSAAE LQAMVCGSPD IPLGLLKSVA
TYKGFDPSSA LVTWFWEVME EFTNQERSLF LRFVWGRTRL PRTIADFRGR DFVLQVLEKN
PPDHFLPESY TCFFLLKMPR YSCKAVLLEK LKYAIHFCKS IDTGEYARVA MGEPTEATGS
EDNSDLESVA SHEG
//
