ID B1PXD2_9ALPH Unreviewed; 577 AA.
AC B1PXD2;
DT 29-APR-2008, integrated into UniProtKB/TrEMBL.
DT 29-APR-2008, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=Envelope glycoprotein E {ECO:0000256|ARBA:ARBA00013988};
GN Name=US8 {ECO:0000313|EMBL:AMR55965.1};
OS Suid alphaherpesvirus 1.
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Orthoherpesviridae; Alphaherpesvirinae; Varicellovirus;
OC Varicellovirus suidalpha1.
OX NCBI_TaxID=10345 {ECO:0000313|EMBL:ACA97995.1};
RN [1] {ECO:0000313|EMBL:ACA97995.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NiA3 {ECO:0000313|EMBL:ACA97995.1};
RA Gomez-Sebastian S., Tabares E.;
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AMR55965.1, ECO:0000313|Proteomes:UP000139029}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIA3 {ECO:0000313|EMBL:AMR55965.1};
RX PubMed=27231370;
RA Mathijs E., Vandenbussche F., Verpoest S., De Regge N., Van Borm S.;
RT "Complete Genome Sequence of Pseudorabies Virus Reference Strain NIA3 Using
RT Single-Molecule Real-Time Sequencing.";
RL Genome Announc. 4:0-0(2016).
CC -!- FUNCTION: In epithelial cells, the heterodimer gE/gI is required for
CC the cell-to-cell spread of the virus, by sorting nascent virions to
CC cell junctions. Once the virus reaches the cell junctions, virus
CC particles can spread to adjacent cells extremely rapidly through
CC interactions with cellular receptors that accumulate at these
CC junctions. Implicated in basolateral spread in polarized cells. In
CC neuronal cells, gE/gI is essential for the anterograde spread of the
CC infection throughout the host nervous system. Together with US9, the
CC heterodimer gE/gI is involved in the sorting and transport of viral
CC structural components toward axon tips.
CC {ECO:0000256|ARBA:ARBA00025134}.
CC -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
CC Endosome membrane {ECO:0000256|ARBA:ARBA00004190}; Single-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004190}. Host Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004152}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004152}. Host cell junction
CC {ECO:0000256|ARBA:ARBA00004315}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004235}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004235}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
CC -!- SIMILARITY: Belongs to the alphaherpesvirinae glycoprotein E family.
CC {ECO:0000256|ARBA:ARBA00008101}.
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DR EMBL; EU502923; ACA97995.1; -; Genomic_DNA.
DR EMBL; KU900059; AMR55965.1; -; Genomic_DNA.
DR IntAct; B1PXD2; 1.
DR Proteomes; UP000139029; Genome.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-SubCell.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044156; C:host cell junction; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR003404; Herpes_glycopE_Fc.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR Pfam; PF02480; Herpes_gE; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
PE 3: Inferred from homology;
KW Host cell junction {ECO:0000256|ARBA:ARBA00023081};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host endosome {ECO:0000256|ARBA:ARBA00023046};
KW Host Golgi apparatus {ECO:0000256|ARBA:ARBA00022812};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000256|ARBA:ARBA00022879,
KW ECO:0000313|EMBL:AMR55965.1}; Virion {ECO:0000256|ARBA:ARBA00022844}.
FT TRANSMEM 429..454
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 227..386
FT /note="Envelope glycoprotein E Fc-binding"
FT /evidence="ECO:0000259|Pfam:PF02480"
FT REGION 481..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 577 AA; 62428 MW; 0AFCE4D95C2C4F4F CRC64;
MRPFLLRAAQ LLALLALALS TEAPSLSAET TPGPVTEVPS PSAEVWDLST EAGDNDLDGD
LNGDDRRAGF GSALASLREA PPAHLVNVSE GANFTLDARG DGAVVAGIWT FLPVRGCDAV
AVTMVCFETA CHPDLVLGRA CVPEAPERGI GDYLPPEVPR LQREPPIVTP ERWSPHLTVR
RATPNDTGLY TLHDASGPRA VFFVAVGDRP PAPLAPVGPA RHEPRFHAFG FHSQLFSPGD
TFDLMPRVVS DMGDSRENFT ATLDWYYARA PPRCLLYYVY EPCIYHPRAP ECLRPVDPAC
SFTSPARARL VARRAYASCS PLLGDRWLTA CPFDAFGEEV HTNATADESG LYVLVMTHNG
HVATWDYTLV ATAAEYVTVI KELTAPARAP GTPWGPGGGD DAIYVDGVTT PAPPARPWNP
YGRTTPGRLF VLALGSFVMT CVVGGAVWLC VLCSRRRAAS RPFRVPTRAG TRMLSPVYTS
LPTHEDYYDG DDDDEEAGVA RRRPSSPGGD SGYEGPYVSL DAEDEFSSDE DDGLYVRPEE
APRSGFDVWF RDPEKPEVTN GPNYGVTASR LLNARPA
//
