ID B1VTX8_STRGG Unreviewed; 724 AA.
AC B1VTX8;
DT 20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT 20-MAY-2008, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=Putative fatty acid oxidation complex alpha-subunit {ECO:0000313|EMBL:BAG17822.1};
GN OrderedLocusNames=SGR_993 {ECO:0000313|EMBL:BAG17822.1};
OS Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=455632 {ECO:0000313|EMBL:BAG17822.1, ECO:0000313|Proteomes:UP000001685};
RN [1] {ECO:0000313|EMBL:BAG17822.1, ECO:0000313|Proteomes:UP000001685}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 4626 / NBRC 13350 {ECO:0000313|Proteomes:UP000001685};
RX PubMed=18375553; DOI=10.1128/JB.00204-08;
RA Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H.,
RA Yamashita A., Hattori M., Horinouchi S.;
RT "Genome sequence of the streptomycin-producing microorganism Streptomyces
RT griseus IFO 13350.";
RL J. Bacteriol. 190:4050-4060(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SIMILARITY: In the central section; belongs to the 3-hydroxyacyl-CoA
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00007005}.
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DR EMBL; AP009493; BAG17822.1; -; Genomic_DNA.
DR RefSeq; WP_003964882.1; NC_010572.1.
DR AlphaFoldDB; B1VTX8; -.
DR GeneID; 6212730; -.
DR KEGG; sgr:SGR_993; -.
DR PATRIC; fig|455632.4.peg.989; -.
DR eggNOG; COG1024; Bacteria.
DR eggNOG; COG1250; Bacteria.
DR HOGENOM; CLU_009834_15_3_11; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000001685; Chromosome.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43612; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA; 1.
DR PANTHER; PTHR43612:SF3; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NAD {ECO:0000256|ARBA:ARBA00023027}.
FT DOMAIN 322..500
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 503..603
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 724 AA; 77664 MW; BB0536F17AE701BB CRC64;
MTESTTIRWE QDETGVVTLV LDDPNQSANT MNQAFKDSIA AVADRAEAEK DSIRGIIYTS
AKKTFFAGGD LKDMIKVGPE NAQDAFDAGN AIKASLRRIE TLGKPVVAAI NGAALGGGYE
IALACHHRVA LDAPGSRIGL PEVTLGLLPA GGGVTRTVRL MGIADALLKV LLQGTQYTPR
RALENGLVHE VAATREEMTE KARAFIDAHP ESQQPWDVKG YRIPGGTPSN PKFAANLPAF
PANLKKQLAG APMPAPRNIL AAAVEGSQVD FETALTIEAR YFTELVTGQV SKNMIQAFFF
DLQAVNSGAN RPGGIPERPV RKVAVLGAGM MGAGIAYSCA RAGIDVVLKD VSAEAAAKGK
AYSEKLLAKA LSRGRTTEAK RDELLARITP TGDAADLAGC DAVIEAVFED TALKHKVFQE
IQDVIEPDAL LCSNTSTLPI TVLAEGVSRP VDFIGLHFFS PVDKMPLVEI IKGERTGDEA
LARAFDLVRR IKKTPIVVND SRGFFTSRVI GQFINEGVAM VGEGVEPASI EQAAAQSGYP
AKVLSLMDEL TLTLPRKIRN ETRRAVEEAG GSWPGHPSDE VIDRMVDEFG RTGRSGGAGF
YDYDEDGKRA GLWPGLREHF TGKADGDVPF EDMKERMLFS EALDSVRCLE ENVLISVADA
NIGSIMGIGF PPWTGGVLQY INGYEGGLPG FVARARELAE RYGDRFLPPA LLVEKAEKGE
TFHD
//
