ID B1W1E5_STRGG Unreviewed; 1162 AA.
AC B1W1E5;
DT 20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT 20-MAY-2008, sequence version 1.
DT 27-MAR-2024, entry version 101.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN OrderedLocusNames=SGR_2341 {ECO:0000313|EMBL:BAG19170.1};
OS Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=455632 {ECO:0000313|EMBL:BAG19170.1, ECO:0000313|Proteomes:UP000001685};
RN [1] {ECO:0000313|EMBL:BAG19170.1, ECO:0000313|Proteomes:UP000001685}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 4626 / NBRC 13350 {ECO:0000313|Proteomes:UP000001685};
RX PubMed=18375553; DOI=10.1128/JB.00204-08;
RA Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H.,
RA Yamashita A., Hattori M., Horinouchi S.;
RT "Genome sequence of the streptomycin-producing microorganism Streptomyces
RT griseus IFO 13350.";
RL J. Bacteriol. 190:4050-4060(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; AP009493; BAG19170.1; -; Genomic_DNA.
DR RefSeq; WP_012379131.1; NC_010572.1.
DR AlphaFoldDB; B1W1E5; -.
DR GeneID; 6215439; -.
DR KEGG; sgr:SGR_2341; -.
DR PATRIC; fig|455632.4.peg.2383; -.
DR eggNOG; COG0210; Bacteria.
DR eggNOG; COG2887; Bacteria.
DR HOGENOM; CLU_003630_1_1_11; -.
DR Proteomes; UP000001685; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF55; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 17..364
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 365..681
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 878..931
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 896..910
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 913..931
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 38..45
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1162 AA; 126349 MW; E89DB5267CBD97F9 CRC64;
MSPRITDPEQ LKELLGIPFT PEQTACITAP PAPQVIVAGA GSGKTTVMAA RVVWLVGTGQ
VAPEQVLGLT FTNKAAGELA ERVRKALIAA GVTDPDVIDP DNPPGEPTIS TYHAFAGRLL
TEHGLRIGLE PSTRLLADAT RYQLAAKVLR EAPGPYPALT RSFSTLVSDL LALDGELSEH
LVRPGTLETY DTELLRDLAT ARLSNADLRK IPEAAEARRS LLGLTERYRA AKRSRDLLDF
GDQIALSAEL ALTRPEVGRI LREEFRVVLL DEYQDTSVAQ RLLLSALFGA GTAPGEDGQA
PTGHPPPGQA PTGHAVTAVG DPCQAIYGWR GASVANLDDF PEHFPHADGT PATRYSLSEN
RRSGGRLLQL ANGLAEPLRA MHEGVEALRP APGAERDGMV RCALLRTHTE EIAWLADSLA
HLVRTGTPPG EIAVLCRTAG DFPEIQAALV ARDIPVEVVG LAGLLHLPEV ADLVAVCEVL
QDPGANASLV RLLTGPRWRI GPRDLALLGR RARLLVHRAG HADDADADQR LADAVEGTDP
AEVISLADAL DTFLVVADAA DDGLPFSAEA RVRFARLARE LRDLRRSLAD PLMDVLHRVL
ATTGLEVELS ASPQALAARR RETLANFLDI AARFASLDGE ASLLAFLGFL RTAAQYEKGL
DNALPGGENT VKVLTAHKSK GLEWDVVAAP GLVTGQFPSD RGREAWIAQP QVLPHALRGD
AATLPALDPH DGLDAKAVKA FKAEMKEHQH TEELRLGYVT FTRPRSLLLG SGHWWGPSQK
RTRGPSAFLE ALYEHCAAGH GEIEAWVDEP AEDEENPALA ERDADLAWPL PLDADALARR
RAARDTVLAH LERMAAGEPS YGPAPADVPA DEPLFEEEPF KEEPADEDWD WDALPTDRPP
GPPEAEPDTD PVPHIPAARH PREDPAAGRL TPEEARTLAS WDRDLDSLAG ELRRARASVR
EVLVPAALSA TQLLRLAEDP DAFARELARP MPRPPQPAAR RGTRFHAWVE SRYEELPLPM
LGPDELPGGD ENDAEIADER DLAELKEAFE RTPYARRTPY RVETPFQITL AGRVIRGRID
AVYRTGDRYE IVDWKTTRHR TADPLQLAVY RLAWAELHGL PLDEVSATFL YVRSGETVRP
RDLPGRAELE RILLDEPTPE DG
//
