ID B1W4I4_STRGG Unreviewed; 443 AA.
AC B1W4I4;
DT 20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT 20-MAY-2008, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE SubName: Full=Putative GntR-family transcriptional regulator with an aminotransferase domain {ECO:0000313|EMBL:BAG23001.1};
GN OrderedLocusNames=SGR_6172 {ECO:0000313|EMBL:BAG23001.1};
OS Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=455632 {ECO:0000313|EMBL:BAG23001.1, ECO:0000313|Proteomes:UP000001685};
RN [1] {ECO:0000313|EMBL:BAG23001.1, ECO:0000313|Proteomes:UP000001685}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 4626 / NBRC 13350 {ECO:0000313|Proteomes:UP000001685};
RX PubMed=18375553; DOI=10.1128/JB.00204-08;
RA Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H.,
RA Yamashita A., Hattori M., Horinouchi S.;
RT "Genome sequence of the streptomycin-producing microorganism Streptomyces
RT griseus IFO 13350.";
RL J. Bacteriol. 190:4050-4060(2008).
CC -!- SIMILARITY: In the C-terminal section; belongs to the class-I
CC pyridoxal-phosphate-dependent aminotransferase family.
CC {ECO:0000256|ARBA:ARBA00005384}.
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DR EMBL; AP009493; BAG23001.1; -; Genomic_DNA.
DR RefSeq; WP_012381758.1; NC_010572.1.
DR AlphaFoldDB; B1W4I4; -.
DR GeneID; 6209891; -.
DR KEGG; sgr:SGR_6172; -.
DR eggNOG; COG1167; Bacteria.
DR HOGENOM; CLU_017584_2_0_11; -.
DR Proteomes; UP000001685; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd00609; AAT_like; 1.
DR CDD; cd07377; WHTH_GntR; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR004839; Aminotransferase_I/II.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46577; HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR; 1.
DR PANTHER; PTHR46577:SF1; HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR; 1.
DR Pfam; PF00155; Aminotran_1_2; 1.
DR Pfam; PF00392; GntR; 1.
DR SMART; SM00345; HTH_GNTR; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50949; HTH_GNTR; 1.
PE 3: Inferred from homology;
KW Aminotransferase {ECO:0000313|EMBL:BAG23001.1};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000313|EMBL:BAG23001.1}.
FT DOMAIN 9..77
FT /note="HTH gntR-type"
FT /evidence="ECO:0000259|PROSITE:PS50949"
FT REGION 67..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 443 AA; 45888 MW; B111E784E7CA6B8B CRC64;
MLGEYRISGR RAAEIAASVE RGVGSGDLPP GHVLPPMREL AARLEVNPNT VAAAYRTLRE
RGVIETAGRR GSRVRPAPAS TSRGSLRIEA PPGVRDLGEG NPDPELLPDL GPALAAAAAA
DAADRGLYGQ AAVVEEFAAH ARAALDADGV PAGPVAVTSG ALDAIERVLA AHLRPGDAVA
VEDPGWGSVL DLVPALGLRA VPVGVDDSGP LPAEVERALR AGARALVVTD RAQNPTGASL
DAERARELRA VLGRHPDVLL IEDDHGHAIV DLPLHPLAGV TAHWAFIRSA AKAYGPDLRV
ATLTGDAVTV DRVTGRQRLG PGWVSRLLQR AVLHLWTSDA VDTRAVSRSY GDRRDALIHA
LAERGVSARG RSGMNVWVPV SDETGAVARL LHAGWAAAPG ARFRLETPQG VRLTVSPLSA
ADIGPLADAV AAAAGPARPV SYG
//
