ID B1WBF6_XENTR Unreviewed; 528 AA.
AC B1WBF6;
DT 20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT 20-MAY-2008, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Mannosyltransferase {ECO:0000256|RuleBase:RU363075};
DE EC=2.4.1.- {ECO:0000256|RuleBase:RU363075};
GN Name=pigb {ECO:0000313|RefSeq:NP_001120608.1,
GN ECO:0000313|Xenbase:XB-GENE-996679};
GN Synonyms=LOC100145769 {ECO:0000313|EMBL:AAI61737.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI61737.1};
RN [1] {ECO:0000313|RefSeq:NP_001120608.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAI61737.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Small intestine {ECO:0000313|EMBL:AAI61737.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001120608.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Mannosyltransferase involved in glycosylphosphatidylinositol-
CC anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-
CC GlcN-acyl-PI during GPI precursor assembly.
CC {ECO:0000256|ARBA:ARBA00025591}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|RuleBase:RU363075}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU363075}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 22 family.
CC {ECO:0000256|RuleBase:RU363075}.
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DR EMBL; BC161737; AAI61737.1; -; mRNA.
DR RefSeq; NP_001120608.1; NM_001127136.1.
DR CAZy; GT22; Glycosyltransferase Family 22.
DR GeneID; 100145769; -.
DR KEGG; xtr:100145769; -.
DR AGR; Xenbase:XB-GENE-996679; -.
DR CTD; 9488; -.
DR Xenbase; XB-GENE-996679; pigb.
DR OMA; FNNYGYL; -.
DR OrthoDB; 37262at2759; -.
DR Proteomes; UP000008143; Chromosome 3.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR InterPro; IPR005599; GPI_mannosylTrfase.
DR PANTHER; PTHR22760; GLYCOSYLTRANSFERASE; 1.
DR PANTHER; PTHR22760:SF4; GPI MANNOSYLTRANSFERASE 3; 1.
DR Pfam; PF03901; Glyco_transf_22; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU363075};
KW Glycosyltransferase {ECO:0000256|RuleBase:RU363075,
KW ECO:0000313|RefSeq:NP_001120608.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363075};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU363075};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU363075}.
FT TRANSMEM 213..236
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363075"
FT TRANSMEM 248..268
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363075"
FT TRANSMEM 296..316
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363075"
FT TRANSMEM 328..344
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363075"
FT TRANSMEM 350..369
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363075"
FT TRANSMEM 376..394
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363075"
SQ SEQUENCE 528 AA; 61124 MW; 537940961CC8E7F9 CRC64;
MDKVRSRAMW PYRRQDSQGA VKLRKRKSRL YSKEASSACT GAGLFGENTY LVLAAVGFRI
FNCMMVQTSF VPDEYWQSLE VAHKMTFNYG YLTWEWTEGL RGFSYPLMFA TIYKALYLLG
KDHVWCLIWV PRLVQAVFSG IADIRLYSLV RHLENTELAK WVFFCQLCSW FTWYCSTRTL
TNTMEAVLST FALYYYPLEG SNTKNSTKYL ICVALAFLIR PTAVILWVPL LFYHFAKEKK
KADLVVNQYL PVGILTLATS LIVDRIFFGK WTFVQWNFLK FNVLQDLGSF YGSHPWHWYF
TQGLPVILCT HLPFFIHGCM VAPKKYQILL VAVGWTVLTY SALSHKEFRF IYPVLPVCMV
FCGFSFSNLK RWKKAAVGFL VLSNLFPALY TGLIHQRGAL DIMPGIQKLC QTENSSASLF
VLMPCHSIPF YSHVHCPIKM NFLECPPDLS DAYVDEAELF YASPLAWLNA EFYNKTLLPT
HLIMFSVLEP EILSFLTNNY VKTMSVFHTH VPEGRTGSHI YMYERKSK
//
