ID B1YLA7_EXIS2 Unreviewed; 690 AA.
AC B1YLA7;
DT 20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT 20-MAY-2008, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Penicillin-binding protein transpeptidase {ECO:0000313|EMBL:ACB60339.1};
GN OrderedLocusNames=Exig_0859 {ECO:0000313|EMBL:ACB60339.1};
OS Exiguobacterium sibiricum (strain DSM 17290 / CIP 109462 / JCM 13490 /
OS 255-15).
OC Bacteria; Bacillota; Bacilli; Bacillales;
OC Bacillales Family XII. Incertae Sedis; Exiguobacterium.
OX NCBI_TaxID=262543 {ECO:0000313|EMBL:ACB60339.1, ECO:0000313|Proteomes:UP000001681};
RN [1] {ECO:0000313|EMBL:ACB60339.1, ECO:0000313|Proteomes:UP000001681}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17290 / CIP 109462 / JCM 13490 / 255-15
RC {ECO:0000313|Proteomes:UP000001681};
RX PubMed=16489412; DOI=10.1007/s00792-005-0497-5;
RA Rodrigues D.F., Goris J., Vishnivetskaya T., Gilichinsky D.,
RA Thomashow M.F., Tiedje J.M.;
RT "Characterization of Exiguobacterium isolates from the Siberian permafrost.
RT Description of Exiguobacterium sibiricum sp. nov.";
RL Extremophiles 10:285-294(2006).
RN [2] {ECO:0000313|EMBL:ACB60339.1, ECO:0000313|Proteomes:UP000001681}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17290 / CIP 109462 / JCM 13490 / 255-15
RC {ECO:0000313|Proteomes:UP000001681};
RX PubMed=19019206; DOI=10.1186/1471-2164-9-547;
RA Rodrigues D.F., Ivanova N., He Z., Huebner M., Zhou J., Tiedje J.M.;
RT "Architecture of thermal adaptation in an Exiguobacterium sibiricum strain
RT isolated from 3 million year old permafrost: a genome and transcriptome
RT approach.";
RL BMC Genomics 9:547-547(2008).
RN [3] {ECO:0000313|Proteomes:UP000001681}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17290 / CIP 109462 / JCM 13490 / 255-15
RC {ECO:0000313|Proteomes:UP000001681};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kiss H., Chertkov O., Monk C.,
RA Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F.,
RA Land M., Hauser L., Kyrpides N., Mikhailova N., Vishnivetskaya T.,
RA Rodrigues D.F., Gilichinsky D., Tiedje J., Richardson P.;
RT "Complete sequence of chromosome of Exiguobacterium sibiricum 255-15.";
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
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DR EMBL; CP001022; ACB60339.1; -; Genomic_DNA.
DR RefSeq; WP_012369763.1; NC_010556.1.
DR AlphaFoldDB; B1YLA7; -.
DR STRING; 262543.Exig_0859; -.
DR KEGG; esi:Exig_0859; -.
DR eggNOG; COG0768; Bacteria.
DR HOGENOM; CLU_009289_7_0_9; -.
DR OrthoDB; 9770103at2; -.
DR Proteomes; UP000001681; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR Gene3D; 1.10.10.1230; Penicillin-binding protein, N-terminal non-catalytic domain, head sub-domain; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001681};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 63..294
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 347..661
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 690 AA; 77152 MW; 3633589ED60BAE1F CRC64;
MAKRITVKGK RRNHLPLRLN LMFFVVFLLF AILIFRLGVV QIVNGEKISR EVQKTEMIAS
KYEVPRGKIY DRDGRLLVDT ISKYSIVYRR SQNTKVDERI EIASRLAAII NLPKDDWKVT
ERDMKDYWVA VNGEESDRRY KQAVEKRYPD AEKQNKLSIS EQDQIRLDTI TKKDIDFDDK
TMEIIAIKHN MEVGYALDPQ LVKLGASAKE MAIIDENLED LKGVSVEPFY ERSYPYEGTL
RNIFGKYSKI PAEQQAEFKA KGYSLNDRVG TSFLEQQYED LLRGKPAYDV YETFNGEPVG
EPNREEGESG KDLVLTVDAE YNKQVDQILQ QAIKMGRGMG SGYLKEGYAV VMNPKTGEIL
AMSGQKLDTA TNKFSDVAIN NVLTSLQIGS TIKGATVAMG LEEGVIRQNE VINDAPITIG
GTKKGSYVNM GPITDLTALE RSSNVYMFNI AMRMAKYPSN GVAGASVDAA AAIMQNYYSQ
FGLGVTTGID LPYEAKGVQG TPDRVTLLMD RVIGQYDAFT PLQVAQYVST LANGGYRVQP
HFLKEVLASN SIEDETKKVD YSFKTNYLNR IEVSQANIDH VREGFHRVVK GERGTAKIIA
QTGIDAAAKT GTAQVSVYGE DGIALRDGSG QPVRSLNSNL VGWAPYDNPE MAWAVFLPYM
EQETVNSKIG HDLVKAYFNV KDVPWQTKPN
//
