ID   B2G3Z6_ZYGRO            Unreviewed;       725 AA.
AC   B2G3Z6;
DT   10-JUN-2008, integrated into UniProtKB/TrEMBL.
DT   10-JUN-2008, sequence version 1.
DT   24-JAN-2024, entry version 70.
DE   SubName: Full=Saccharolysin {ECO:0000313|EMBL:CAQ43305.1};
GN   Name=Zr_PRD1 {ECO:0000313|EMBL:CAQ43305.1};
GN   ORFNames=Zrou_1p11 {ECO:0000313|EMBL:CAQ43305.1}, ZYGR_0Y00150
GN   {ECO:0000313|EMBL:GAV50573.1};
OS   Zygosaccharomyces rouxii (Candida mogii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Zygosaccharomyces.
OX   NCBI_TaxID=4956 {ECO:0000313|EMBL:CAQ43305.1};
RN   [1] {ECO:0000313|EMBL:CAQ43305.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CBS 732 {ECO:0000313|EMBL:CAQ43305.1};
RA   Gordon J.L., Wolfe K.H.;
RT   "Zygosaccharomyces rouxii homologs of Saccharomyces cerevisiae chromosome
RT   III.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:GAV50573.1, ECO:0000313|Proteomes:UP000187013}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 110957 {ECO:0000313|EMBL:GAV50573.1,
RC   ECO:0000313|Proteomes:UP000187013};
RA   Watanabe J., Uehara K., Mogi Y., Tsukioka Y.;
RT   "Draft genome sequence of allopolyploid Zygosaccharomyces rouxii.";
RL   Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU003435};
CC       Note=Binds 1 zinc ion. {ECO:0000256|RuleBase:RU003435};
CC   -!- SIMILARITY: Belongs to the peptidase M3 family.
CC       {ECO:0000256|ARBA:ARBA00006040, ECO:0000256|RuleBase:RU003435}.
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DR   EMBL; AM989980; CAQ43305.1; -; Genomic_DNA.
DR   EMBL; BDGX01000025; GAV50573.1; -; Genomic_DNA.
DR   RefSeq; XP_002498002.1; XM_002497957.1.
DR   AlphaFoldDB; B2G3Z6; -.
DR   MEROPS; M03.003; -.
DR   EnsemblFungi; GAV50573; GAV50573; ZYGR_0Y00150.
DR   GeneID; 8205776; -.
DR   KEGG; zro:ZYRO0F18392g; -.
DR   eggNOG; KOG2089; Eukaryota.
DR   OMA; KNFQSAM; -.
DR   OrthoDB; 735202at2759; -.
DR   Proteomes; UP000187013; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd06455; M3A_TOP; 1.
DR   Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR   Gene3D; 1.10.1370.10; Neurolysin, domain 3; 1.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR024077; Neurolysin/TOP_dom2.
DR   InterPro; IPR024080; Neurolysin/TOP_N.
DR   InterPro; IPR045090; Pept_M3A_M3B.
DR   InterPro; IPR001567; Pept_M3A_M3B_dom.
DR   PANTHER; PTHR11804; PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED; 1.
DR   PANTHER; PTHR11804:SF84; SACCHAROLYSIN; 1.
DR   Pfam; PF01432; Peptidase_M3; 1.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003435};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU003435};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW   ECO:0000256|RuleBase:RU003435};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU003435};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU003435}.
FT   DOMAIN          264..723
FT                   /note="Peptidase M3A/M3B catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF01432"
SQ   SEQUENCE   725 AA;  83784 MW;  5745046131715262 CRC64;
     MLLRSCSRVA GFTRKSIFSV VAVPALAIGI YRVSKFQYST MSSPNLFIAP QSAPSWAFTP
     QSLLDETHRL IESSKQFYDS LAQLSNPTVE NLVKPYMHHE NGVGLIESQL TFPQQVSADK
     EIRDASVQAT EFLQNFGIEQ SLRHDLFLQF DKIWNELKDK SFEQGSQEYE IYKYVEKIHR
     DYTRDGLQLP EDKRDKVKQL KIKIAANSLE FSKNLGEQKE FVAFTKEELD GVSESVMDQF
     EQFKDENGTT KYKVTFKYPD IFPVLKTAKN PKTRKLAFAR DQDKVPQNEK LFVETLQLRN
     ELADILGYST YANYNLELKM AKNQDNVWKF LNELKDKLKP LGLKEAENLK QIKQKECESL
     GLPYDGHYYV WDHRYYDNKY LKDNYNVDLE KISEYYPIES TISGMLSIYE TLLKLKFVEE
     TDPEKRSVWH EDVKQLAVWK MDNPSKPEFV GWIYFDLHPR DGKYGHAANF GISASYVKED
     GTRSYPVTAL VCNFSKPSAK KPSLLKHNEI STFFHELGHG IHDLVGENRL TTFNGPGAVP
     WDFVEAPSQM LEFWTWNERE LHELSSHYES GEKIPKDLLQ SLISTKHVDG ALFALRQLHF
     GLFDMYVHTS KNVAKLDLLK LWNELREEVS LVENGDTFTK GYDSFGHIMS DSYSAGYYGY
     MWAEVFAADM YHTRFAADPL DSKAGVQYRD IVLGRGGLYE TNDNLREFLG REPSEEAFLK
     ELGLN
//