ID   B2GQG8_DANRE            Unreviewed;       431 AA.
AC   B2GQG8;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   SubName: Full=Krt18 protein {ECO:0000313|EMBL:AAI64730.1};
GN   Name=krt18a.1 {ECO:0000313|ZFIN:ZDB-GENE-030411-6};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI64730.1};
RN   [1] {ECO:0000313|EMBL:AAI64730.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=PCR rescue {ECO:0000313|EMBL:AAI64730.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000256|RuleBase:RU000685}.
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DR   EMBL; BC164730; AAI64730.1; -; mRNA.
DR   RefSeq; NP_848524.1; NM_178437.2.
DR   AlphaFoldDB; B2GQG8; -.
DR   SMR; B2GQG8; -.
DR   GeneID; 352912; -.
DR   KEGG; dre:352912; -.
DR   AGR; ZFIN:ZDB-GENE-030411-6; -.
DR   CTD; 352912; -.
DR   ZFIN; ZDB-GENE-030411-6; krt18a.1.
DR   OrthoDB; 4640531at2759; -.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.20.5.500; Single helix bin; 1.
DR   Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR002957; Keratin_I.
DR   PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR   PANTHER; PTHR23239:SF377; KERATIN, TYPE I CYTOSKELETAL 18-RELATED; 1.
DR   Pfam; PF00038; Filament; 1.
DR   PRINTS; PR01248; TYPE1KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW   ECO:0000256|RuleBase:RU000685}.
FT   DOMAIN          84..395
FT                   /note="IF rod"
FT                   /evidence="ECO:0000259|PROSITE:PS51842"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          88..122
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          193..231
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          286..387
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   431 AA;  48603 MW;  0756B43A11F04A74 CRC64;
     MSLRTSYSVR SSTSQVPVSQ ASIKRTTNVP TYRAASIYGG AGGQGTRISS ASYSGVRSGL
     GVPSMSSSIQ VSASGSTGEI MGNEKMAMQN LNDRLASYLE KVRILEQANS KLELKIREAL
     EKRGPDVHDY SRFQPIVDEL RKKIFDATTN NARLVLQIDN ARLAADDFRV KYESELSIRQ
     GVEADITGLR KVIDDTNLNR MNLESEIEAL KEELIFLKKN HDNEVMELRN QISQSGVQVD
     VDAPKGQDLS QIMEEIRAKY EKMALKNQEE LKAWHESQIT EVQVQVTQNT EALQGARSEV
     NELRRQIQTL EIELESQKNL KGSLEGTLRD TEMRYNMEIE NLNTIILQLE AELTQLRGNI
     QHQTQEYEAL LNIKMKLEAE IATYRRLLDG GDFKLQDALE EQKKVKVMTV TQTLVDGKVV
     SSSTETKERK L
//