ID B2GTX7_XENLA Unreviewed; 601 AA.
AC B2GTX7;
DT 10-JUN-2008, integrated into UniProtKB/TrEMBL.
DT 10-JUN-2008, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Vacuolar protein sorting-associated protein 33A {ECO:0000256|ARBA:ARBA00039493};
GN Name=vps33a.L {ECO:0000313|RefSeq:NP_001121352.1,
GN ECO:0000313|Xenbase:XB-GENE-5485259};
GN Synonyms=LOC100158448 {ECO:0000313|EMBL:AAI66051.1}, vps33a
GN {ECO:0000313|RefSeq:NP_001121352.1,
GN ECO:0000313|Xenbase:XB-GENE-5485259};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAI66051.1};
RN [1] {ECO:0000313|RefSeq:NP_001121352.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAI66051.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAI66051.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001121352.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Early endosome {ECO:0000256|ARBA:ARBA00004412}.
CC Endosome membrane {ECO:0000256|ARBA:ARBA00004125}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004125}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004125}. Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00004492}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004492}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004492}. Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004630}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004630}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004630}.
CC -!- SIMILARITY: Belongs to the STXBP/unc-18/SEC1 family.
CC {ECO:0000256|ARBA:ARBA00009884}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC166051; AAI66051.1; -; mRNA.
DR RefSeq; NP_001121352.1; NM_001127880.1.
DR STRING; 8355.B2GTX7; -.
DR PaxDb; 8355-B2GTX7; -.
DR GeneID; 100158448; -.
DR KEGG; xla:100158448; -.
DR AGR; Xenbase:XB-GENE-5485259; -.
DR CTD; 100158448; -.
DR Xenbase; XB-GENE-5485259; vps33a.L.
DR OMA; FHIFFVP; -.
DR OrthoDB; 22722at2759; -.
DR Proteomes; UP000186698; Chromosome 1L.
DR Bgee; 100158448; Expressed in brain and 19 other cell types or tissues.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.25.40.850; -; 1.
DR Gene3D; 3.40.50.1910; -; 1.
DR Gene3D; 3.40.50.2060; -; 1.
DR InterPro; IPR043154; Sec-1-like_dom1.
DR InterPro; IPR043127; Sec-1-like_dom3a.
DR InterPro; IPR001619; Sec1-like.
DR InterPro; IPR027482; Sec1-like_dom2.
DR InterPro; IPR036045; Sec1-like_sf.
DR InterPro; IPR043155; VPS33_dom3b.
DR PANTHER; PTHR11679:SF85; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 33A; 1.
DR PANTHER; PTHR11679; VESICLE PROTEIN SORTING-ASSOCIATED; 1.
DR Pfam; PF00995; Sec1; 1.
DR SUPFAM; SSF56815; Sec1/munc18-like (SM) proteins; 1.
PE 2: Evidence at transcript level;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
SQ SEQUENCE 601 AA; 68191 MW; 0B01F84E06DA9666 CRC64;
MAAHLSCGRV NLNVLREAMR MELREFLDKC AGSKAIVWDE YLTGPFGLIA QYSLLKEHEV
EKMFTLKSGP LPSSDVKNII FFVRPRLELM DIIADNIQRE ERGRFPQRDF YILFVPRRSI
LCEQRLKDLG VLGSFMHRDE YRLNLIPFDG DLLSMESESA FKECYLENDQ TSLYQAAKGL
TTLQSLYGTI PQICGKGECA RHVANMMIRM KRELGGSQSQ ITPVFDTLLL LDRNVDLLTP
LATQLTYEGL IDEVYGVQNS HVKLPPEKFA TKNQGEGGKD LPTEPKKLLL NSAEELYAEI
RDKNFNAVGS VLSKKAKIIS AAFEGRHNAK TVGEIKQFVS QLPHMQAEKA SLANHTSIAE
LIKDITTSEA FFDNLTVEQE FMSGFDTDKV NPYIEDCIAK KDPILKILRL VCLQSVCNTG
LKQKVLDYYK REILQTYGYE HLLTLHNLEK AGLLKLQTSS RNNYPTIRKT LRLWMDDVNE
QNPNDISYVY SGYAPLSVRL AQILVRPGWR SIEEVLKILP GPQFEERQSL PPGLLKKRQQ
GENKVILVFF LGGVTFAEIA ALRFLSQMED GGTEYIIATT KLISGTTWIK SLMEKLEPPP
F
//
