ID B2HM20_MYCMM Unreviewed; 435 AA.
AC B2HM20;
DT 10-JUN-2008, integrated into UniProtKB/TrEMBL.
DT 10-JUN-2008, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=HRDC domain-containing protein {ECO:0000259|PROSITE:PS50967};
GN OrderedLocusNames=MMAR_2035 {ECO:0000313|EMBL:ACC40484.1};
OS Mycobacterium marinum (strain ATCC BAA-535 / M).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium ulcerans group.
OX NCBI_TaxID=216594 {ECO:0000313|EMBL:ACC40484.1, ECO:0000313|Proteomes:UP000001190};
RN [1] {ECO:0000313|EMBL:ACC40484.1, ECO:0000313|Proteomes:UP000001190}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-535 / M {ECO:0000313|Proteomes:UP000001190};
RX PubMed=18403782; DOI=10.1101/gr.075069.107;
RA Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K.,
RA Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C.,
RA Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K.,
RA Lord A., Moule S., Mungall K., Norbertczak H., Quail M.A.,
RA Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L., Brosch R.,
RA Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T.;
RT "Insights from the complete genome sequence of Mycobacterium marinum on the
RT evolution of Mycobacterium tuberculosis.";
RL Genome Res. 18:729-741(2008).
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DR EMBL; CP000854; ACC40484.1; -; Genomic_DNA.
DR RefSeq; WP_011741115.1; NC_010612.1.
DR AlphaFoldDB; B2HM20; -.
DR STRING; 216594.MMAR_2035; -.
DR GeneID; 72433438; -.
DR KEGG; mmi:MMAR_2035; -.
DR eggNOG; COG0349; Bacteria.
DR HOGENOM; CLU_042387_3_0_11; -.
DR OrthoDB; 144122at2; -.
DR Proteomes; UP000001190; Chromosome.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR CDD; cd06142; RNaseD_exo; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 2.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR041605; Exo_C.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR47649; RIBONUCLEASE D; 1.
DR PANTHER; PTHR47649:SF1; RIBONUCLEASE D; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF18305; DNA_pol_A_exoN; 1.
DR Pfam; PF00570; HRDC; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00341; HRDC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001190}.
FT DOMAIN 245..325
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 321..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 435 AA; 47123 MW; 6E084B01BEDC3373 CRC64;
MCSALSPEGN EPPEGTAPEA TPLLSPASGV PELSVTAGQI EAAATLLDRG SGPFAVDAER
ASGFRYSNRA YLIQIRRAGA GTVLIDPVSH GGDPLTVLQP LAEVLAKDEW ILHSADQDLP
CLAEVGMRPS ALYDTELAGR LAGYDRVNLA TMVERLLGMG LVKGHGAADW SKRPLPSDWL
NYAALDVELL IELRSAISGV LAEQGKSDWA AQEFEYLRTF ESRWVPATAK PDRWRRTSGI
HKVRDRRGLA AVRELWITRD RIAERRDIAP RRILPDSAII DAALSDPKSV EDLVSLPVFG
GRNQRRNATM WLGALDVARK SQHPPEVAEP SNGPPVPARW SRRKPEAAAR LEAARAALSE
VSDSVGVPTE NLVTPELVRR LCWDWAPVAA AEITSTIDEF LATGQARVWQ RELVVPALAA
ALANAAEPET EPGAR
//
