ID B2HS44_MYCMM Unreviewed; 504 AA.
AC B2HS44;
DT 10-JUN-2008, integrated into UniProtKB/TrEMBL.
DT 10-JUN-2008, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Serine protease HtrA (DegP protein) {ECO:0000313|EMBL:ACC42622.1};
GN Name=htrA {ECO:0000313|EMBL:ACC42622.1};
GN OrderedLocusNames=MMAR_4214 {ECO:0000313|EMBL:ACC42622.1};
OS Mycobacterium marinum (strain ATCC BAA-535 / M).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium ulcerans group.
OX NCBI_TaxID=216594 {ECO:0000313|EMBL:ACC42622.1, ECO:0000313|Proteomes:UP000001190};
RN [1] {ECO:0000313|EMBL:ACC42622.1, ECO:0000313|Proteomes:UP000001190}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-535 / M {ECO:0000313|Proteomes:UP000001190};
RX PubMed=18403782; DOI=10.1101/gr.075069.107;
RA Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K.,
RA Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C.,
RA Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K.,
RA Lord A., Moule S., Mungall K., Norbertczak H., Quail M.A.,
RA Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L., Brosch R.,
RA Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T.;
RT "Insights from the complete genome sequence of Mycobacterium marinum on the
RT evolution of Mycobacterium tuberculosis.";
RL Genome Res. 18:729-741(2008).
CC -!- SIMILARITY: Belongs to the peptidase S1C family.
CC {ECO:0000256|ARBA:ARBA00010541}.
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DR EMBL; CP000854; ACC42622.1; -; Genomic_DNA.
DR RefSeq; WP_012395787.1; NC_010612.1.
DR AlphaFoldDB; B2HS44; -.
DR STRING; 216594.MMAR_4214; -.
DR GeneID; 34341259; -.
DR KEGG; mmi:MMAR_4214; -.
DR eggNOG; COG0265; Bacteria.
DR HOGENOM; CLU_020120_3_7_11; -.
DR OrthoDB; 9758917at2; -.
DR Proteomes; UP000001190; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00987; PDZ_serine_protease; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001940; Peptidase_S1C.
DR PANTHER; PTHR43343; PEPTIDASE S12; 1.
DR PANTHER; PTHR43343:SF3; PROTEASE DO-LIKE 8, CHLOROPLASTIC; 1.
DR Pfam; PF13180; PDZ_2; 1.
DR Pfam; PF13365; Trypsin_2; 1.
DR PRINTS; PR00834; PROTEASES2C.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:ACC42622.1};
KW Membrane {ECO:0000256|SAM:Phobius}; Protease {ECO:0000313|EMBL:ACC42622.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001190};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 416..490
FT /note="PDZ"
FT /evidence="ECO:0000259|SMART:SM00228"
FT REGION 1..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 96..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..71
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..113
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 504 AA; 52026 MW; 43306E90BD30180D CRC64;
MTSDQGNNSG QDGGPRLAPR PISRPPVDSA ARQTFGRPSG VQGSFVAERV RPQRYRDQSE
YEPHDQPADP VLEEAFSRPV GGADSLQRHP IDAGALDAEK DGGQADEADD PWRDPGAAAA
LGTPAVAAPL PQGALGRTGK LGVRDVLFGG QVSYLALIVL AVIALVIGAL GGVIGRKTAE
VVEAFTTSKV TLSTNGNAQE PAGRFTKVAA AVADSVVTIE TKSDQEGMQG SGVIVDGRGY
IVTNNHVISE AANNPSQFKT TVVFNDGKEV PASLVGRDPK TDLAVLKVDN VDNLTVARLG
NSDKVRVGDE VLAVGAPLGL RSTVTEGIVS ALHRPVPLSG EGSDTDTVID AIQTDASINH
GNSGGPLIDM DSQVIGINTA GKSLSDSASG LGFAIPVNEM KFVAETLIKD GKIVHPTIGI
TTRSVSNAIA SGAQVANVKA GSPAQKAGIL ENDVIVKIGN RSVADSDEFV VAVRQLTIGQ
DAPVEVVRDG RHVTLTVKPD PDSS
//
