ID B2IY60_NOSP7 Unreviewed; 753 AA.
AC B2IY60;
DT 10-JUN-2008, integrated into UniProtKB/TrEMBL.
DT 10-JUN-2008, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Sodium/hydrogen exchanger {ECO:0000313|EMBL:ACC84659.1};
GN OrderedLocusNames=Npun_R6387 {ECO:0000313|EMBL:ACC84659.1};
OS Nostoc punctiforme (strain ATCC 29133 / PCC 73102).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae; Nostoc.
OX NCBI_TaxID=63737 {ECO:0000313|EMBL:ACC84659.1, ECO:0000313|Proteomes:UP000001191};
RN [1] {ECO:0000313|Proteomes:UP000001191}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29133 / PCC 73102 {ECO:0000313|Proteomes:UP000001191};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Meeks J.C., Elhai J.,
RA Campbell E.L., Thiel T., Longmire J., Potts M., Atlas R.;
RT "Complete sequence of chromosome of Nostoc punctiforme ATCC 29133.";
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACC84659.1, ECO:0000313|Proteomes:UP000001191}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29133 / PCC 73102 {ECO:0000313|Proteomes:UP000001191};
RX PubMed=23463784; DOI=10.1104/pp.112.213116;
RA Ekman M., Picossi S., Campbell E.L., Meeks J.C., Flores E.;
RT "A Nostoc punctiforme Sugar Transporter Necessary to Establish a
RT Cyanobacterium-Plant Symbiosis.";
RL Plant Physiol. 161:1984-1992(2013).
CC -!- SIMILARITY: Belongs to the universal stress protein A family.
CC {ECO:0000256|ARBA:ARBA00008791}.
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DR EMBL; CP001037; ACC84659.1; -; Genomic_DNA.
DR AlphaFoldDB; B2IY60; -.
DR STRING; 63737.Npun_R6387; -.
DR EnsemblBacteria; ACC84659; ACC84659; Npun_R6387.
DR KEGG; npu:Npun_R6387; -.
DR eggNOG; COG0475; Bacteria.
DR eggNOG; COG0589; Bacteria.
DR HOGENOM; CLU_367868_0_0_3; -.
DR PhylomeDB; B2IY60; -.
DR Proteomes; UP000001191; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR CDD; cd00293; USP_Like; 2.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR006015; Universal_stress_UspA.
DR InterPro; IPR006016; UspA.
DR PANTHER; PTHR32468; CATION/H + ANTIPORTER; 1.
DR PANTHER; PTHR32468:SF0; K(+)_H(+) ANTIPORTER 1; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF00582; Usp; 2.
DR PRINTS; PR01438; UNVRSLSTRESS.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001191};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 29..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 60..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 99..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 128..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 162..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 197..221
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 259..280
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 315..334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 346..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 388..405
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 411..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 39..434
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT DOMAIN 460..596
FT /note="UspA"
FT /evidence="ECO:0000259|Pfam:PF00582"
FT DOMAIN 615..750
FT /note="UspA"
FT /evidence="ECO:0000259|Pfam:PF00582"
SQ SEQUENCE 753 AA; 80795 MW; 384A1084EE61DE12 CRC64;
MQNLSLMLVP VLAAQKAAGD GLIKPLGHHE LLLVLVQLSL LLLVARGLGE LMRRINLPPV
VGELLAGVLL GPSLFGLLLP DLQAHIFPKS QEQSNLLSVI SWLGVLFLLI VTGLETDLKL
ILRKGKTALL ISLGGIIIPF ITGFGLGWLL PDNFLADPEK RLVFSLFIAT AMSISAVPVI
AKVLMDLNLI RRDIGQVTLA AGMTDDTIGW ILLSVVSGLA SSGKFDLGTI FHSVSAAILF
LAIAFTIGRT IVDQILRWVD DYVGGIAASM SVVLILSLAA AALTHALGLE AALGAFVLGI
LAGQSRRFSN EAGHMLEVFT ASFLAPIFFA SAGLKVNLLA LLVPQTLLFG LIVLAVACVG
KFTGAYLGSR VGGLSHWEGL AMGSGMNARG AMEIVVATIG LSLGVLNPQM YSIIVMVAIV
TSLMAPPLLR WTLSKVVMSE EEARRLEQEE QDSRSFIKQI QRVLIPTSGG PNIQLAAQLV
GYMAHQNSIE VTSLYALSDK QPQKKGRRAA TQVKDTAAEE ALASVAEEMQ LPDDTTLQTK
MESGRSKAEV ILNEANKNYD LIVLGASEQI RPQKTLFNLL VDRVVQEAPC ATMVVKSHLP
QAKGKICKIA QQKLTKILVP TVGTEYSKNA VEMASTIAAQ TGALVMIVNV INLPQVEYIL
YEQRSLTPVK EIAHDLLEQQ AAIGRNLGAD VKTYILQGSS PEREILKFAQ TQEVDLIILG
SSIRMVTGRV FFGHRVDAIL SKAHCPVAVI TTP
//
