ID B2RU64_MOUSE Unreviewed; 274 AA.
AC B2RU64;
DT 01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 01-JUL-2008, sequence version 1.
DT 03-MAY-2023, entry version 79.
DE SubName: Full=Frequently rearranged in advanced T-cell lymphomas {ECO:0000313|EMBL:AAI40988.1};
GN Name=Frat1 {ECO:0000313|EMBL:AAI40988.1, ECO:0000313|MGI:MGI:109450};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAI40988.1};
RN [1] {ECO:0000313|EMBL:AAI40988.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain {ECO:0000313|EMBL:AAI40988.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the GSK-3-binding protein family.
CC {ECO:0000256|ARBA:ARBA00010422}.
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DR EMBL; BC140987; AAI40988.1; -; mRNA.
DR RefSeq; NP_032069.2; NM_008043.3.
DR AlphaFoldDB; B2RU64; -.
DR SMR; B2RU64; -.
DR EPD; B2RU64; -.
DR PeptideAtlas; B2RU64; -.
DR DNASU; 14296; -.
DR GeneID; 14296; -.
DR KEGG; mmu:14296; -.
DR AGR; MGI:109450; -.
DR CTD; 10023; -.
DR MGI; MGI:109450; Frat1.
DR VEuPathDB; HostDB:ENSMUSG00000067199; -.
DR OMA; GWMRGSA; -.
DR OrthoDB; 5324110at2759; -.
DR PhylomeDB; B2RU64; -.
DR BioGRID-ORCS; 14296; 3 hits in 17 CRISPR screens.
DR ExpressionAtlas; B2RU64; baseline and differential.
DR InterPro; IPR008014; GSK3-bd.
DR PANTHER; PTHR35154; GBP PROTEIN; 1.
DR PANTHER; PTHR35154:SF1; PROTO-ONCOGENE FRAT1; 1.
DR Pfam; PF05350; GSK-3_bind; 1.
PE 2: Evidence at transcript level;
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 55..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 132..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 232..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..23
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..194
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 274 AA; 28875 MW; 1C0482997EA95323 CRC64;
MPCRREEEEE AGDEAEGEED DDSFLLLQQS VTLGGSTDVD QLIVQIGETL QLDAAHDRPA
SPCAAPGPPP PQVLAALPAD KTGTPARRLL RPTGSAETGN PAPPGAVRCV LGERGRVRGR
SAPYCVAEIS PGASALPQQP GLDGPPGTGK LSTPQPLSGP CRRGWLRNAA ASRRLQQRRG
SQPETRTGDD DDPHRLLQQL VLSGNLIKEA VRRLHSRQLQ LHAKLPAHPF LGPLSAPVHE
PPSPGSPRAA CSDPGAFMGR AQLRTGDDLL VPGS
//
