ID B2ULU9_AKKM8 Unreviewed; 327 AA.
AC B2ULU9;
DT 01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 01-JUL-2008, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Metallophosphoesterase {ECO:0000313|EMBL:ACD03993.1};
GN OrderedLocusNames=Amuc_0149 {ECO:0000313|EMBL:ACD03993.1};
OS Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC
OS 81048 / CCUG 64013 / CIP 107961 / Muc).
OC Bacteria; Verrucomicrobiota; Verrucomicrobiae; Verrucomicrobiales;
OC Akkermansiaceae; Akkermansia.
OX NCBI_TaxID=349741 {ECO:0000313|EMBL:ACD03993.1, ECO:0000313|Proteomes:UP000001031};
RN [1] {ECO:0000313|Proteomes:UP000001031}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013
RC / CIP 107961 / Muc {ECO:0000313|Proteomes:UP000001031};
RX PubMed=21390229; DOI=10.1371/journal.pone.0016876;
RA van Passel M.W., Kant R., Zoetendal E.G., Plugge C.M., Derrien M.,
RA Malfatti S.A., Chain P.S., Woyke T., Palva A., de Vos W.M., Smidt H.;
RT "The genome of Akkermansia muciniphila, a dedicated intestinal mucin
RT degrader, and its use in exploring intestinal metagenomes.";
RL PLoS ONE 6:E16876-E16876(2011).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP001071; ACD03993.1; -; Genomic_DNA.
DR AlphaFoldDB; B2ULU9; -.
DR PaxDb; 349741-Amuc_0149; -.
DR KEGG; amu:Amuc_0149; -.
DR eggNOG; COG1409; Bacteria.
DR HOGENOM; CLU_848981_0_0_0; -.
DR OrthoDB; 9791866at2; -.
DR BioCyc; AMUC349741:G1GBX-174-MONOMER; -.
DR Proteomes; UP000001031; Chromosome.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR CDD; cd00838; MPP_superfamily; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR PANTHER; PTHR43143; METALLOPHOSPHOESTERASE, CALCINEURIN SUPERFAMILY; 1.
DR PANTHER; PTHR43143:SF1; SERINE_THREONINE-PROTEIN PHOSPHATASE CPPED1; 1.
DR Pfam; PF00149; Metallophos; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000001031};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..327
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002783638"
FT DOMAIN 24..232
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF00149"
FT REGION 303..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 327 AA; 37018 MW; 7652DD9947E41C5F CRC64;
MKYLALFLMF LLQPVLAEDT APWKIAIIGD THDSPKRMEG SEGVAVNFIK TLYGEILKHN
VDMVVQVGDM ADIEGSAPVK GLAKRKELNK ILREKGIPFY AVRGNHESLP FRAEQFRELF
LPTRKQGTKG LATRKLNYGI RHKNASLYFM DIDLTPDQLV DFSAWVKRNR SKANTVPRHC
LVFTHRTLQT PMQFRECLWG RYNDSAAEQQ NIFYRNLRDA GVRFVVTGHL HAHDLYMITS
PDGQNTLTSL ICAPAGNKVL PIPFLLPAKS RVKTLQYRSG ITAYYILTIY PDSMTLDTYA
APNNGTTDEG PQSGEFNKLN SYTIPMD
//
