ID B2UNP0_AKKM8 Unreviewed; 917 AA.
AC B2UNP0;
DT 01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 01-JUL-2008, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Tetratricopeptide TPR_2 repeat protein {ECO:0000313|EMBL:ACD05756.1};
GN OrderedLocusNames=Amuc_1943 {ECO:0000313|EMBL:ACD05756.1};
OS Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC
OS 81048 / CCUG 64013 / CIP 107961 / Muc).
OC Bacteria; Verrucomicrobiota; Verrucomicrobiae; Verrucomicrobiales;
OC Akkermansiaceae; Akkermansia.
OX NCBI_TaxID=349741 {ECO:0000313|EMBL:ACD05756.1, ECO:0000313|Proteomes:UP000001031};
RN [1] {ECO:0000313|Proteomes:UP000001031}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013
RC / CIP 107961 / Muc {ECO:0000313|Proteomes:UP000001031};
RX PubMed=21390229; DOI=10.1371/journal.pone.0016876;
RA van Passel M.W., Kant R., Zoetendal E.G., Plugge C.M., Derrien M.,
RA Malfatti S.A., Chain P.S., Woyke T., Palva A., de Vos W.M., Smidt H.;
RT "The genome of Akkermansia muciniphila, a dedicated intestinal mucin
RT degrader, and its use in exploring intestinal metagenomes.";
RL PLoS ONE 6:E16876-E16876(2011).
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DR EMBL; CP001071; ACD05756.1; -; Genomic_DNA.
DR RefSeq; WP_012420970.1; NZ_CP071807.1.
DR AlphaFoldDB; B2UNP0; -.
DR STRING; 349741.Amuc_1943; -.
DR PaxDb; 349741-Amuc_1943; -.
DR KEGG; amu:Amuc_1943; -.
DR eggNOG; COG0457; Bacteria.
DR eggNOG; COG1196; Bacteria.
DR HOGENOM; CLU_317541_0_0_0; -.
DR OrthoDB; 9766710at2; -.
DR BioCyc; AMUC349741:G1GBX-2072-MONOMER; -.
DR Proteomes; UP000001031; Chromosome.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR12558; CELL DIVISION CYCLE 16,23,27; 1.
DR PANTHER; PTHR12558:SF13; CELL DIVISION CYCLE PROTEIN 27 HOMOLOG; 1.
DR Pfam; PF13414; TPR_11; 1.
DR Pfam; PF14559; TPR_19; 1.
DR SMART; SM00028; TPR; 5.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 3.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001031};
KW Signal {ECO:0000256|SAM:SignalP};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..917
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002781777"
FT REPEAT 649..682
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 683..716
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 717..750
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 112..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 532..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 799..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 843..917
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 191..412
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 112..127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 532..552
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 901..917
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 917 AA; 101184 MW; C89E7434D31A56CB CRC64;
MMTPLPLGIT LALSLTCGSM PLLAQGSYMP GPMPATAGTK QDPTDMYLEA LRLVTQAAGL
VEKRDYIGAI RLTQQAEDKF GRLAKSYPQW RPNLLQTRRQ LNRENLDQWQ KLAQQQAAAS
SSSGLELERP ASVPKRPRPK PNIALPPGYK GVEFPTRPGE SLINTIPSPS VSPGAAPEVV
ESNYERIRRL LDKTTMENNA LIQALKRTRR EQEEILAKLA VASAGESVYR DELLKVKKQM
EDERKTSNKL IQTLTRRVEE LEQNVTSLSQ DKARYLAQIA DLQLQLKEYQ DKLDKVTDEK
NALQKDRDQL AALVELNSPD KTKNLLDRNL TLAAQLKDAQ DKIAALETAK SDSEEQRKAN
LKALEEAREE SADLKQKLIA IRDENIGYRK RITELNTKLI NADVELSKLE ANPEKSPLLL
EENQLLRSTI AKQLRILSVQ DQSRSLLIST YKRLHQENPD TAEIASLMDN EEAIKLTPAE
KQIVNAIARD NNINVPLTDQ QKEKINKLAQ ALSAERGKAA QLARDLELAR SQMKTKADKS
ARNDKKQAEA LARAQKALEQ KNIQVEELTR QMEELKSRSA EQARLAAISA GTITPDQEKA
LNRSMEATVR RKLEAEALGQ GAAEAFAKKR YAAAEQLYRT LLDFQPAHVP ALVNLGTILL
QRNKAEEAIK FLKKATELDA SSSPAWFMMG VAQYRAGEDH HAIASLTETV RLDPANAPAL
LYLGNLETSA GNYEKAVAHF ENALKIQPES PDAHFNLAWT YSRLGRTAQA RKSYDAAIRC
GGLPDSDLEL AITGTTTLPR KKQAADQNPA SAAKEDGPQL AAAISDPSAI PHDANEVPAH
VAEDPNAQEK PSAGPKQVVV SHRPETEPIS LAAQMRETAP AAASAQPPAE AATAATETPK
PEKQEPPRRK SRFRIGS
//
