ID B2UPB4_AKKM8 Unreviewed; 818 AA.
AC B2UPB4;
DT 01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 01-JUL-2008, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Cell divisionFtsK/SpoIIIE {ECO:0000313|EMBL:ACD05885.1};
GN OrderedLocusNames=Amuc_2076 {ECO:0000313|EMBL:ACD05885.1};
OS Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC
OS 81048 / CCUG 64013 / CIP 107961 / Muc).
OC Bacteria; Verrucomicrobiota; Verrucomicrobiae; Verrucomicrobiales;
OC Akkermansiaceae; Akkermansia.
OX NCBI_TaxID=349741 {ECO:0000313|EMBL:ACD05885.1, ECO:0000313|Proteomes:UP000001031};
RN [1] {ECO:0000313|Proteomes:UP000001031}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013
RC / CIP 107961 / Muc {ECO:0000313|Proteomes:UP000001031};
RX PubMed=21390229; DOI=10.1371/journal.pone.0016876;
RA van Passel M.W., Kant R., Zoetendal E.G., Plugge C.M., Derrien M.,
RA Malfatti S.A., Chain P.S., Woyke T., Palva A., de Vos W.M., Smidt H.;
RT "The genome of Akkermansia muciniphila, a dedicated intestinal mucin
RT degrader, and its use in exploring intestinal metagenomes.";
RL PLoS ONE 6:E16876-E16876(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FtsK/SpoIIIE/SftA family.
CC {ECO:0000256|ARBA:ARBA00006474}.
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DR EMBL; CP001071; ACD05885.1; -; Genomic_DNA.
DR AlphaFoldDB; B2UPB4; -.
DR STRING; 349741.Amuc_2076; -.
DR PaxDb; 349741-Amuc_2076; -.
DR KEGG; amu:Amuc_2076; -.
DR eggNOG; COG1674; Bacteria.
DR eggNOG; COG3170; Bacteria.
DR HOGENOM; CLU_001981_9_7_0; -.
DR OrthoDB; 9807790at2; -.
DR Proteomes; UP000001031; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 3.30.980.40; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR025199; FtsK_4TM.
DR InterPro; IPR041027; FtsK_alpha.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR018541; Ftsk_gamma.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22683:SF41; DNA TRANSLOCASE FTSK; 1.
DR PANTHER; PTHR22683; SPORULATION PROTEIN RELATED; 1.
DR Pfam; PF13491; FtsK_4TM; 1.
DR Pfam; PF17854; FtsK_alpha; 1.
DR Pfam; PF09397; FtsK_gamma; 1.
DR Pfam; PF01580; FtsK_SpoIIIE; 1.
DR SMART; SM00843; Ftsk_gamma; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50901; FTSK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618, ECO:0000313|EMBL:ACD05885.1};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Reference proteome {ECO:0000313|Proteomes:UP000001031};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 55..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 89..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 144..162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 442..678
FT /note="FtsK"
FT /evidence="ECO:0000259|PROSITE:PS50901"
FT REGION 207..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 734..754
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 459..466
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 818 AA; 89982 MW; 7FC35ED5C10623D7 CRC64;
MVWGVVSLLG GAALLAAMLT FDVREIGWSY LNGSGQVIPG TSNVLGTVGL YGAGIFYWTL
GGMAWMLVVL LEWWGLYRLL HYGRLPRSVV YGGLFLLLFG CLFLAAGHVP GNEWVARHQV
QGAGGLVGHL LGTGLFFPLA GRSAVLAFSG LGYLLALVYA AGMRPRPFCR AMLREWRAWR
MNRKEKRLAR QTALLAREAA RVRASMEDAA LSAPRPVRKG RASVPRLQRT GDDLESLYHE
AAAVAPSKPE DSVPPPSAPR TQGRLPLAPR PRITVAEPAE MKPAPKEQPF SKLSTPPTEE
FREYELPPFE LLHYEEKPEG PTAEDKEEML EIQQKIIDTL TTFRVDVTPG DITRGPTITR
YEVYPARGVR VNTFDQYAKD IALATKAESV NIVAPIPGKD TVGIEIVNRK KVAVPLRELL
QDPAFCSPKK KIPLALGKDV YGRTVIGDLA SMPHLLVAGA TGSGKSVCIN SIISSMLLKF
RPDELRLILV DPKVVEMQPY SKLPHLIVPV VTDPKKVPNA LRWCVNEMEH RYHCFAKVGV
RNFEAFNKRP PDVPAQETEE PEDGQVDEAL AESIARDLES QGEWPVEEDD ELDLEDDGVI
PERFPYIVII IDELADLMQT VGADIETNIG RLTQKARAAG IHLIVATQTP RRQVVTGTIK
ANIPTRIAFQ VASGTDSRVI LDRQGAEKLV GKGDLLYLPP GSAQVERAQG AFISDDEVEA
LVAHCASQAK QKFHEEVQKS LDEPSRGGAD SPLDDAEEEC YAKCLEVAVV ERKVSTSLLQ
RRLSIGYGRA ARMMDLLESR GIIAPADNTN RPRKVLVE
//
