ID B2WAK5_PYRTR Unreviewed; 856 AA.
AC B2WAK5;
DT 01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 01-JUL-2008, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=isoleucine--tRNA ligase {ECO:0000256|ARBA:ARBA00013165};
DE EC=6.1.1.5 {ECO:0000256|ARBA:ARBA00013165};
DE AltName: Full=Isoleucyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00032665};
GN ORFNames=PTRG_07318 {ECO:0000313|EMBL:EDU50237.1};
OS Pyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus)
OS (Drechslera tritici-repentis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae;
OC Pyrenophora.
OX NCBI_TaxID=426418 {ECO:0000313|EMBL:EDU50237.1, ECO:0000313|Proteomes:UP000001471};
RN [1] {ECO:0000313|Proteomes:UP000001471}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pt-1C-BFP {ECO:0000313|Proteomes:UP000001471};
RX PubMed=23316438; DOI=10.1534/g3.112.004044;
RA Manning V.A., Pandelova I., Dhillon B., Wilhelm L.J., Goodwin S.B.,
RA Berlin A.M., Figueroa M., Freitag M., Hane J.K., Henrissat B., Holman W.H.,
RA Kodira C.D., Martin J., Oliver R.P., Robbertse B., Schackwitz W.,
RA Schwartz D.C., Spatafora J.W., Turgeon B.G., Yandava C., Young S., Zhou S.,
RA Zeng Q., Grigoriev I.V., Ma L.-J., Ciuffetti L.M.;
RT "Comparative genomics of a plant-pathogenic fungus, Pyrenophora tritici-
RT repentis, reveals transduplication and the impact of repeat elements on
RT pathogenicity and population divergence.";
RL G3 (Bethesda) 3:41-63(2013).
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DR EMBL; DS231621; EDU50237.1; -; Genomic_DNA.
DR RefSeq; XP_001937650.1; XM_001937615.1.
DR AlphaFoldDB; B2WAK5; -.
DR STRING; 426418.B2WAK5; -.
DR EnsemblFungi; EDU50237; EDU50237; PTRG_07318.
DR GeneID; 6345591; -.
DR eggNOG; KOG0433; Eukaryota.
DR HOGENOM; CLU_001493_7_2_1; -.
DR InParanoid; B2WAK5; -.
DR OMA; PVYWGTE; -.
DR OrthoDB; 656at2759; -.
DR Proteomes; UP000001471; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:EnsemblFungi.
DR GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004822; F:isoleucine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0000049; F:tRNA binding; IEA:InterPro.
DR GO; GO:0006428; P:isoleucyl-tRNA aminoacylation; IEA:InterPro.
DR GO; GO:0032543; P:mitochondrial translation; IEA:EnsemblFungi.
DR CDD; cd07960; Anticodon_Ia_Ile_BEm; 1.
DR Gene3D; 1.10.730.20; -; 1.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR Gene3D; 3.90.740.10; Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain; 1.
DR InterPro; IPR002300; aa-tRNA-synth_Ia.
DR InterPro; IPR033708; Anticodon_Ile_BEm.
DR InterPro; IPR002301; Ile-tRNA-ligase.
DR InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR NCBIfam; TIGR00392; ileS; 1.
DR PANTHER; PTHR42765:SF1; ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR42765; SOLEUCYL-TRNA SYNTHETASE; 1.
DR Pfam; PF08264; Anticodon_1; 1.
DR Pfam; PF00133; tRNA-synt_1; 1.
DR PRINTS; PR00984; TRNASYNTHILE.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
PE 4: Predicted;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000313|EMBL:EDU50237.1}; ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000001471}.
FT DOMAIN 5..588
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 643..795
FT /note="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase
FT anticodon-binding"
FT /evidence="ECO:0000259|Pfam:PF08264"
SQ SEQUENCE 856 AA; 95321 MW; 93D7BB491FD5AA30 CRC64;
MAQKKDAAQT DAVSVRRAAR ELATRTIKEQ KKGFKEWAVM GDWDNAYQTM EREFEIRQLG
VFKSMFEKGL VYRMFKPVYW SPSSRTALAE AELEYDEGFK SLAAFVRYPV RVEEGLRVKL
GGVEGDISVI IWTTTPWTLP ANKAIAVHRD MQYCLVKDAE KGNELILIAA SRVAEYEKIL
EQKLEIVVPD VRGSDLVDQV QYENPFQKAN GLQPIIHADF VTDSSGTGLV HLAPGHGMDD
YNVCMSLNVP AFAPIDDAGA FTKDAFPEHP ELLEGLPVAD IKKTGSNAVC KYLEQLDMLR
AKHNYRHKYP IDWRTKEPVI TRATAQWFAN VEGIKAASMK SISNVNFLPE SGRSRLESFI
QGRSQWCISR QRAWGVPIPA LYKVEDDGTL TATMDSDTIT HIIDIVKRRG IDAWWTDPPD
DPAWTPPHLT GTGTYVRGKD TMDVWFDSGT SWSLLPPPQH PDKPLADVYL EGTDQHRGWF
QSSLLTYIAT HSYTTSDAVV KAPYKTLITH GFTLDAHGRK MSKSLGNVVS PAQIMSGELL
PPVKRKKQKG GAATANNTAA NERNYDTLGA DALRLWAATS DYTRDVTIGQ PMLVAINTSL
HKYRVTFKWL LGIFSLTTCP PPFTSFNNTL SPHDIANLGH LSDRLALHRL AQVSKDVHAC
YSGYEFFKGV GAVNRYIGLD LSAGYFEMIK DRVYTGEKTE CEVLQKVLGV VFYQLLQMLA
PVVPLLAEEV WDHVPSKLRE GSVHPARAIW NPLPQIEGTE ASEKVGRVLG VLGDKIRIAQ
EKMRAEGRIG SGLECGVTIY LEEEGVELLG GLYCEAMGLV GRPTGMSAEL VGEVEKQLEE
LLVLVPGLFP KLQVYK
//
