ID B2WUP1_CHICK Unreviewed; 536 AA.
AC B2WUP1;
DT 01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 01-JUL-2008, sequence version 1.
DT 27-MAR-2024, entry version 120.
DE SubName: Full=Suppressor of cytokine signaling 5 {ECO:0000313|EMBL:ABQ53623.1, ECO:0000313|Ensembl:ENSGALP00010026701.1};
GN Name=SOCS5 {ECO:0000313|EMBL:ABQ53623.1,
GN ECO:0000313|Ensembl:ENSGALP00010026701.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:ABQ53623.1};
RN [1] {ECO:0000313|EMBL:ABQ53623.1}
RP NUCLEOTIDE SEQUENCE.
RA Jin H.;
RT "Evolution of the suppressor of cytokine signaling (SOCS) family.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGALP00010026701.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010026701.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; EF544592; ABQ53623.1; -; mRNA.
DR RefSeq; NP_001120786.1; NM_001127314.1.
DR RefSeq; XP_015139224.1; XM_015283738.1.
DR RefSeq; XP_015139225.1; XM_015283739.1.
DR STRING; 9031.ENSGALP00000016250; -.
DR PaxDb; 9031-ENSGALP00000016250; -.
DR Ensembl; ENSGALT00010044779.1; ENSGALP00010026701.1; ENSGALG00010018511.1.
DR Ensembl; ENSGALT00010044782.1; ENSGALP00010026704.1; ENSGALG00010018511.1.
DR Ensembl; ENSGALT00010044783.1; ENSGALP00010026705.1; ENSGALG00010018511.1.
DR Ensembl; ENSGALT00010044785.1; ENSGALP00010026707.1; ENSGALG00010018511.1.
DR Ensembl; ENSGALT00010044788.1; ENSGALP00010026710.1; ENSGALG00010018511.1.
DR Ensembl; ENSGALT00010044790.1; ENSGALP00010026712.1; ENSGALG00010018511.1.
DR Ensembl; ENSGALT00010044792.1; ENSGALP00010026714.1; ENSGALG00010018511.1.
DR Ensembl; ENSGALT00010044793.1; ENSGALP00010026715.1; ENSGALG00010018511.1.
DR Ensembl; ENSGALT00010044794.1; ENSGALP00010026716.1; ENSGALG00010018511.1.
DR Ensembl; ENSGALT00010044797.1; ENSGALP00010026719.1; ENSGALG00010018511.1.
DR GeneID; 428570; -.
DR KEGG; gga:428570; -.
DR CTD; 9655; -.
DR VEuPathDB; HostDB:geneid_428570; -.
DR eggNOG; KOG4566; Eukaryota.
DR GeneTree; ENSGT00940000159000; -.
DR HOGENOM; CLU_035609_1_0_1; -.
DR OMA; CQNLFNH; -.
DR OrthoDB; 5362214at2759; -.
DR TreeFam; TF321368; -.
DR Reactome; R-GGA-8951664; Neddylation.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000000539; Chromosome 3.
DR Bgee; ENSGALG00000010016; Expressed in brain and 13 other cell types or tissues.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IBA:GO_Central.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IBA:GO_Central.
DR GO; GO:0005154; F:epidermal growth factor receptor binding; IEA:Ensembl.
DR GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:Ensembl.
DR GO; GO:0071404; P:cellular response to low-density lipoprotein particle stimulus; IEA:Ensembl.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:0071638; P:negative regulation of monocyte chemotactic protein-1 production; IEA:Ensembl.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0045629; P:negative regulation of T-helper 2 cell differentiation; IEA:Ensembl.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IBA:GO_Central.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR GO; GO:0045627; P:positive regulation of T-helper 1 cell differentiation; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IEA:InterPro.
DR GO; GO:0097699; P:vascular endothelial cell response to fluid shear stress; IEA:Ensembl.
DR CDD; cd03739; SOCS_SOCS5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR037343; SOCS5_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 2: Evidence at transcript level;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 381..476
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 471..520
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 116..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..159
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 536 AA; 61284 MW; 0C338AD85E2B8C42 CRC64;
MDKVGKMWNN FKYRCQNLFS HEGGSQNENV VVNSSSCSSA KDRTVQITGL AQQQPSSPLR
ENIALQLGLS PSKNSVRRNQ NCVTEIPQIV EISIEKENDS CVTTGARLAR RDSYSRHAPW
GGKKKHSCST KTQSSLDTEK RFGRTRSGLQ RRERRYGVSS VHDMDAASNR TVGSRSLRQR
LQDTVGLCFP MRTYSKQSKP LFSNKRKIHL SELMLEKCPF PAGSDLAQKW HLIKQHTAPV
SPHSTFFDTF DPSLVSTEDE EDRLRERRRL SIEEGVDPPP NAQIHTFEAT AQVNPLYKLG
PKLAPGMTEL TGDKNATPPG NCDSEEDTTT LCLQSRRQKQ RQMSGENHGH ISKQGAWKVH
TQIDYIHCLV PDLLQITGNP CYWGVMDRYE AEALLEGKPE GTFLLRDSAQ EDYLFSVSFR
RYNRSLHARI EQWNHNFSFD AHDPCVFHSS TVTGLLEHYK DPSSCMFFEP LLTVSLNRTF
PFSLQYICRA VICRCTTYDG IDDLPLPSML QDFLKEYHYK QKVRVRWLER EPIKTK
//
