ID B2Y3L9_STREE Unreviewed; 681 AA.
AC B2Y3L9;
DT 01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 01-JUL-2008, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
DE Flags: Fragment;
GN Name=pbp1a {ECO:0000313|EMBL:ACB14491.1};
OS Streptococcus pneumoniae.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1313 {ECO:0000313|EMBL:ACB14491.1};
RN [1] {ECO:0000313|EMBL:ACB14491.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=580.1GR00 {ECO:0000313|EMBL:ACB14491.1};
RX PubMed=18394970; DOI=10.1016/j.meegid.2008.02.001;
RA Stanhope M.J., Lefebure T., Walsh S.L., Becker J.A., Lang P.,
RA Pavinski Bitar P.D., Miller L.A., Italia M.J., Amrine-Madsen H.;
RT "Positive selection in penicillin-binding proteins 1a, 2b, and 2x from
RT Streptococcus pneumoniae and its correlation with amoxicillin resistance
RT development.";
RL Infect. Genet. Evol. 8:331-339(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
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DR EMBL; EU377943; ACB14491.1; -; Genomic_DNA.
DR AlphaFoldDB; B2Y3L9; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR NCBIfam; TIGR02074; PBP_1a_fam; 1.
DR NCBIfam; NF038272; strep_PBP1A; 1.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF29; PENICILLIN-BINDING PROTEIN 1A; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 42..218
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 313..600
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT REGION 633..681
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACB14491.1"
FT NON_TER 681
FT /evidence="ECO:0000313|EMBL:ACB14491.1"
SQ SEQUENCE 681 AA; 75337 MW; C6231699E399946C CRC64;
LVIAAIVLGG GVFFYYVSKA PSLSESKLVA TTSSKIYDNK NQLIADLGSE RRVNAQANDI
PTDLVKAIVS IEDHRFFDHR GIDTIRILGA FLRNLQSNSL QGGSTLTQQL IKLTYFSTST
SDQTISRKAQ EAWLAIQLEQ KATKQEILTY YINKVYMSNG NYGMQTAAQN YYGKDLNNLS
LPQLALLAGM PQAPNQYDPY SHPEAAQDRR NLVLSEMKNQ GYISAEQYEK AVNTPITDGL
QSLKSASNYP AYMDNYLKEV INQVEEETGY NLLTTGMDVY TNVDQEAQKH LWDIYNTDEY
VAYPDDELQV ASTIVDVSNG KVIAQLGARH QSSNVSFGIN QAVETNRDWG STMKPITDYA
PALEYGVYDS TATIVHDEPY NYPGTDIPVY NWDRGYFGNI TLQYALQQSR NVPAVETLNK
VGLDRAKAFL NGLGIDYPSI HYANAISSNT IESNKQYGAS SEKMAAAYAA FANGGIYHKP
MYINKIVFSD GSEKEFSNVG TRAMKETTAY MMTEMMKTVL AYGTGRGAYI PSLPQAGKTG
TSNYTDDEIE KYIKNTGYVA PDEMFVGYTR KYSMAVWTGY SNRLTPIVGD GFLVAAKVYR
SMMTYLSEGS NPEDWNIPEG LYRNGEFVFK NGARSTWNSP APQQPPSTES SSSSSDSSTS
QSSSTTPSTN NSTTTNPNNN T
//