ID B2ZI58_DROSI Unreviewed; 389 AA.
AC B2ZI58;
DT 01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 01-JUL-2008, sequence version 1.
DT 22-FEB-2023, entry version 36.
DE RecName: Full=Hsp90 chaperone protein kinase-targeting subunit {ECO:0000256|ARBA:ARBA00031396};
GN Name=Cdc37 {ECO:0000313|EMBL:ACD56248.1};
OS Drosophila simulans (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7240 {ECO:0000313|EMBL:ACD56248.1};
RN [1] {ECO:0000313|EMBL:ACD56248.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SpiethD {ECO:0000313|EMBL:ACD56248.1};
RX PubMed=18560591; DOI=10.1371/journal.pone.0002442;
RA McDermott S.R., Kliman R.M.;
RT "Estimation of isolation times of the island species in the Drosophila
RT simulans complex from multilocus DNA sequence data.";
RL PLoS ONE 3:E2442-E2442(2008).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the CDC37 family.
CC {ECO:0000256|ARBA:ARBA00006222}.
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DR EMBL; EU670449; ACD56248.1; -; Genomic_DNA.
DR AlphaFoldDB; B2ZI58; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005158; F:insulin receptor binding; IEA:EnsemblMetazoa.
DR GO; GO:0019901; F:protein kinase binding; IEA:InterPro.
DR GO; GO:0046628; P:positive regulation of insulin receptor signaling pathway; IEA:EnsemblMetazoa.
DR GO; GO:0002052; P:positive regulation of neuroblast proliferation; IEA:EnsemblMetazoa.
DR Gene3D; 6.10.140.250; -; 1.
DR Gene3D; 1.20.58.610; Cdc37, Hsp90 binding domain; 1.
DR InterPro; IPR004918; Cdc37.
DR InterPro; IPR013873; Cdc37_C.
DR InterPro; IPR013874; Cdc37_Hsp90-bd.
DR InterPro; IPR038189; Cdc37_Hsp90-bd_sf.
DR InterPro; IPR013855; Cdc37_N_dom.
DR PANTHER; PTHR12800; CDC37-RELATED; 1.
DR PANTHER; PTHR12800:SF4; HSP90 CO-CHAPERONE CDC37; 1.
DR Pfam; PF08564; CDC37_C; 1.
DR Pfam; PF08565; CDC37_M; 1.
DR Pfam; PF03234; CDC37_N; 1.
DR SMART; SM01069; CDC37_C; 1.
DR SMART; SM01070; CDC37_M; 1.
DR SMART; SM01071; CDC37_N; 1.
DR SUPFAM; SSF101391; Hsp90 co-chaperone CDC37; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}.
FT DOMAIN 1..121
FT /note="Cdc37 N-terminal"
FT /evidence="ECO:0000259|SMART:SM01071"
FT DOMAIN 114..278
FT /note="Cdc37 Hsp90 binding"
FT /evidence="ECO:0000259|SMART:SM01070"
FT DOMAIN 282..373
FT /note="Cdc37 C-terminal"
FT /evidence="ECO:0000259|SMART:SM01069"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 343..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 40..98
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 8..23
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 344..374
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 389 AA; 45077 MW; 25E6E9B0DC5606D0 CRC64;
MVDYSKWKNI EISDDEDDTH PNIDTPSLFR WRHQARVERM AEMDHEKDEF KKKRQSYQAR
LMDVKERISK KDGDEEALKK ELEKIEADGK ELDRIESEMI KKEKKTPWNV DTISKPGFEK
TVINKKAGRK ADENLSEEER EQRMRQFVKE NEKLCKQYGM LRKYDDSKRF LQEHLHLVGE
ETANYLVIWS INLEMEEKHE LMAHVAHQCI CMQYILELAK QLDVDPRACV SSFFSKIQHC
QPEYRAQFDS EIEGFKGRIQ KRAQEKIQEA IAQAEEEERK ERLGPGGLDP ADVFESLPDE
LKACFESRDV ELLQKTIAAM PVDVAKLHMK RCVDSGLWVP NAADLEGDKK EEDDSGDAAG
GEEKTDDAKS ESAAKEEPIY TGVSTEDVD
//
