ID B3CH64_9BACE Unreviewed; 360 AA.
AC B3CH64;
DT 22-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2008, sequence version 1.
DT 24-JAN-2024, entry version 56.
DE SubName: Full=Efflux transporter, RND family, MFP subunit {ECO:0000313|EMBL:EDV05478.1};
GN ORFNames=BACINT_04625 {ECO:0000313|EMBL:EDV05478.1};
OS Bacteroides intestinalis DSM 17393.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=471870 {ECO:0000313|EMBL:EDV05478.1, ECO:0000313|Proteomes:UP000004596};
RN [1] {ECO:0000313|EMBL:EDV05478.1, ECO:0000313|Proteomes:UP000004596}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17393 {ECO:0000313|EMBL:EDV05478.1,
RC ECO:0000313|Proteomes:UP000004596};
RA Sudarsanam P., Ley R., Guruge J., Turnbaugh P.J., Mahowald M., Liep D.,
RA Gordon J.;
RT "Draft genome sequence of Bacteroides intestinalis (DSM 17393).";
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EDV05478.1, ECO:0000313|Proteomes:UP000004596}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17393 {ECO:0000313|EMBL:EDV05478.1,
RC ECO:0000313|Proteomes:UP000004596};
RA Fulton L., Clifton S., Fulton B., Xu J., Minx P., Pepin K.H., Johnson M.,
RA Thiruvilangam P., Bhonagiri V., Nash W.E., Mardis E.R., Wilson R.K.;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDV05478.1}.
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DR EMBL; ABJL02000008; EDV05478.1; -; Genomic_DNA.
DR RefSeq; WP_007667308.1; NZ_ABJL02000008.1.
DR AlphaFoldDB; B3CH64; -.
DR STRING; 471870.BACINT_04625; -.
DR eggNOG; COG0845; Bacteria.
DR OrthoDB; 9806939at2; -.
DR Proteomes; UP000004596; Unassembled WGS sequence.
DR GO; GO:0019898; C:extrinsic component of membrane; IEA:InterPro.
DR GO; GO:1990195; C:macrolide transmembrane transporter complex; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 6.10.140.1990; -; 1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR030190; MacA_alpha-hairpin_sf.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30469; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR PANTHER; PTHR30469:SF36; SLL0180 PROTEIN; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..26
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 62..276
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT COILED 148..175
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 360 AA; 39714 MW; 46E9A9B8C86BAD18 CRC64;
MNKKVKWGII IFIGAGLIGG GIYSQLPKEN KELAAADKVM STNRNNKRIL NVNAKIIKPQ
LLKDEIKISG SLLPDEEVDL SFETSGKIIE INFEEGSQVK KGQLLAKVND RPLQAQLQRL
VAQLKLAEDR VFRQNALLER DAVSKEAYEQ VKTELATLNA DIDLIEANIA QTELRAPFDG
VIGLRQVSVG TYASPTTIVA KLTKISPLKV EFSVPERYAN DVKIGAGVNF GLEGKLETFH
AKVYARESRM DQNTHTLTLR ALYPNANGYV MPGRYADIRL SKNEIQDALA VPSEAIVPEM
GKDKIFLYKS GKAQPVEIQT GIRTEAETQV LQGLQEGDTI IISGTLQLRT GLPVTLDNIY
//
