ID B3DUQ1_METI4 Unreviewed; 282 AA.
AC B3DUQ1;
DT 22-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2008, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase {ECO:0000313|EMBL:ACD83054.1};
GN Name=mmsB {ECO:0000313|EMBL:ACD83054.1};
GN OrderedLocusNames=Minf_0999 {ECO:0000313|EMBL:ACD83054.1};
OS Methylacidiphilum infernorum (isolate V4) (Methylokorus infernorum (strain
OS V4)).
OC Bacteria; Verrucomicrobiota; Methylacidiphilae; Methylacidiphilales;
OC Methylacidiphilaceae; Methylacidiphilum (ex Ratnadevi et al. 2023).
OX NCBI_TaxID=481448 {ECO:0000313|EMBL:ACD83054.1, ECO:0000313|Proteomes:UP000009149};
RN [1] {ECO:0000313|EMBL:ACD83054.1, ECO:0000313|Proteomes:UP000009149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate V4 {ECO:0000313|Proteomes:UP000009149};
RX PubMed=18593465; DOI=10.1186/1745-6150-3-26;
RA Hou S., Makarova K.S., Saw J.H., Senin P., Ly B.V., Zhou Z., Ren Y.,
RA Wang J., Galperin M.Y., Omelchenko M.V., Wolf Y.I., Yutin N., Koonin E.V.,
RA Stott M.B., Mountain B.W., Crowe M.A., Smirnova A.V., Dunfield P.F.,
RA Feng L., Wang L., Alam M.;
RT "Complete genome sequence of the extremely acidophilic methanotroph isolate
RT V4, Methylacidiphilum infernorum, a representative of the bacterial phylum
RT Verrucomicrobia.";
RL Biol. Direct 3:26-26(2008).
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DR EMBL; CP000975; ACD83054.1; -; Genomic_DNA.
DR AlphaFoldDB; B3DUQ1; -.
DR STRING; 481448.Minf_0999; -.
DR KEGG; min:Minf_0999; -.
DR eggNOG; COG2084; Bacteria.
DR HOGENOM; CLU_035117_0_6_0; -.
DR Proteomes; UP000009149; Chromosome.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43580; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR PANTHER; PTHR43580:SF2; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027}.
FT DOMAIN 1..146
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 152..270
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 158
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 282 AA; 30656 MW; 51E78B5BDD925424 CRC64;
MARRLHDLKY PVTVVYDINE KAAQELAKEI GAEATNKLAR VTELSDVIFT VVSDDAAMHK
IFAKNGDSLL INAKGKIFIN TATISPQTHI EVGKLCEEVG AEAIEACMAS SIPQARNGTL
YFMLGGKKQV VDEVEPILKD MSSSRRYCGE LGSAAKVKAL VNMVMNINTA ALAEGLGLAK
ALNLDLNMIR EVFSQTGADS RVLHTDGEDM QNREHSCFFS AEHALKDSGI ALNLAKATGL
NLPLAQATYN QYQRLVKKGF GQLDKSAISE LTFPDRHGLD KD
//
