ID B3FFC1_MELMS Unreviewed; 113 AA.
AC B3FFC1;
DT 22-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2008, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Adenosine receptor A3 {ECO:0000256|ARBA:ARBA00021738, ECO:0000256|RuleBase:RU201114};
DE Flags: Fragment;
GN Name=ADORA3 {ECO:0000313|EMBL:ABV56200.1};
OS Melogale moschata (Chinese ferret-badger).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Helictidinae; Melogale.
OX NCBI_TaxID=204267 {ECO:0000313|EMBL:ABV56200.1};
RN [1] {ECO:0000313|EMBL:ABV56200.1}
RP NUCLEOTIDE SEQUENCE.
RA Koepfli K.-P.;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABV56200.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18275614; DOI=10.1186/1741-7007-6-10;
RA Koepfli K.P., Deere K.A., Slater G.J., Begg C., Begg K., Grassman L.,
RA Lucherini M., Veron G., Wayne R.K.;
RT "Multigene phylogeny of the Mustelidae: resolving relationships, tempo and
RT biogeographic history of a mammalian adaptive radiation.";
RL BMC Biol. 6:10-10(2008).
CC -!- FUNCTION: Receptor for adenosine. The activity of this receptor is
CC mediated by G proteins which inhibit adenylyl cyclase.
CC {ECO:0000256|RuleBase:RU201114}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU201114}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU201114}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU201114}.
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DR EMBL; EF987517; ABV56200.1; -; Genomic_DNA.
DR AlphaFoldDB; B3FFC1; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001609; F:G protein-coupled adenosine receptor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000466; Adeno_A3_rcpt.
DR InterPro; IPR001634; Adenosn_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24246:SF2; ADENOSINE RECEPTOR A3; 1.
DR PANTHER; PTHR24246; OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00555; ADENOSINEA3R.
DR PRINTS; PR00424; ADENOSINER.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU201114};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|RuleBase:RU201114};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU201114};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180,
KW ECO:0000256|RuleBase:RU201114};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU201114};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU201114};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU201114};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU201114};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU201114}.
FT TRANSMEM 23..49
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU201114"
FT TRANSMEM 77..100
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU201114"
FT DOMAIN 1..113
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABV56200.1"
FT NON_TER 113
FT /evidence="ECO:0000313|EMBL:ABV56200.1"
SQ SEQUENCE 113 AA; 13449 MW; 7B95AADB62F81851 CRC64;
EYDRNVTFLS CQFRSVVRMD YMVYFSFFTW ILIPLIVMCA IYLDIFYVIR NKLNQNFSNS
KETGAFYGRE FKTAKSLFLV LFLFALSWLP LSIINCITYF HGEVPQIFLY LGI
//
