ID   B3FWU6_MACNE            Unreviewed;       262 AA.
AC   B3FWU6;
DT   22-JUL-2008, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2008, sequence version 1.
DT   27-MAR-2024, entry version 53.
DE   SubName: Full=Granzyme A {ECO:0000313|EMBL:ACD40303.1};
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545 {ECO:0000313|EMBL:ACD40303.1};
RN   [1] {ECO:0000313|EMBL:ACD40303.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=5821 {ECO:0000313|EMBL:ACD40303.1};
RX   PubMed=18665802; DOI=10.1089/aid.2008.0081;
RA   Rollman E., Turner S.J., Kedzierska K., Kent S.J.;
RT   "Anti-SIV cytolytic molecules in pigtail macaques.";
RL   AIDS Res. Hum. Retroviruses 24:1127-1131(2008).
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DR   EMBL; EU526080; ACD40303.1; -; mRNA.
DR   RefSeq; NP_001292861.1; NM_001305932.1.
DR   AlphaFoldDB; B3FWU6; -.
DR   MEROPS; S01.135; -.
DR   GeneID; 105499385; -.
DR   KEGG; mni:105499385; -.
DR   CTD; 3001; -.
DR   OrthoDB; 2878201at2759; -.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   PANTHER; PTHR24271:SF69; GRANZYME A; 1.
DR   PANTHER; PTHR24271; KALLIKREIN-RELATED; 1.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Hydrolase {ECO:0000256|RuleBase:RU363034};
KW   Protease {ECO:0000256|RuleBase:RU363034};
KW   Serine protease {ECO:0000256|RuleBase:RU363034};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           27..262
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002788698"
FT   DOMAIN          29..259
FT                   /note="Peptidase S1"
FT                   /evidence="ECO:0000259|PROSITE:PS50240"
SQ   SEQUENCE   262 AA;  28856 MW;  628240B3F0AB1DC7 CRC64;
     MRNSYRFLAS SLSVVVFLVL IPEDVCEEII GGNEVTPHSR PYMVLLSLDG KTICAGALIA
     EDWVLTAAHC NLDKRSQVIL GAHSITRKER EKQIMRVKKE FPYPCYDPAT HEGDLKLLQL
     TEKAKINKYV TILHLPKKGD DVKPGTMCQV AGWGKIHNSA SQSDTLREVN ITIIDRKICN
     DPNHYNFNPV IGMNMVCAGS LRGGKDSCDG DSGSPLLCNG VFRGVTSFGR KNKCGDPGGP
     CVYILLSKKY LSWIIMTIKG AV
//