ID B3KPJ0_HUMAN Unreviewed; 576 AA.
AC B3KPJ0;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 22-FEB-2023, entry version 83.
DE SubName: Full=cDNA FLJ31851 fis, clone NT2RP7000624, highly similar to Alsin {ECO:0000313|EMBL:BAG51702.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG51702.1};
RN [1] {ECO:0000313|EMBL:BAG51702.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M.,
RA Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S.,
RA Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S.,
RA Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H.,
RA Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M.,
RA Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M.,
RA Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y.,
RA Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N.,
RA Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S.,
RA Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T.,
RA Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M.,
RA Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y.,
RA Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y.,
RA Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T.,
RA Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
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DR EMBL; AK056413; BAG51702.1; -; mRNA.
DR AlphaFoldDB; B3KPJ0; -.
DR MaxQB; B3KPJ0; -.
DR PeptideAtlas; B3KPJ0; -.
DR ProteomicsDB; 3531; -.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13269; PH_alsin; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.20.110.10; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 3.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR003409; MORN.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR46089:SF3; ALSIN; 1.
DR PANTHER; PTHR46089; ALSIN HOMOLOG; 1.
DR Pfam; PF02493; MORN; 7.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00698; MORN; 7.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF82185; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 2: Evidence at transcript level;
FT DOMAIN 2..197
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
SQ SEQUENCE 576 AA; 65072 MW; E6DA7450B494114B CRC64;
MGYIASLHEL ATTERRFYSK LSDIKSQILR PLLSLENLGT TTTVQLLQEV ASRFSKLCYL
IGQHGASLSS FLHGVKEARS LVILKHSSLF LDSYTEYCTS ITNFLVMGGF QLLAKPAIDF
LNKNQELLQD LSEVNDENTQ LMEILNTLFF LPIRRLHNYA KVLLKLATCF EVASPEYQKL
QDSSSCYECL ALHLGRKRKE AEYTLGFWKT FPGKMTDSLR KPERRLLCES SNRALSLQHA
GRFSVNWFIL FNDALVHAQF STHHVFPLAT LWAEPLSEEA GGVNGLKITT PEEQFTLISS
TPQEKTKWLR AISQAVDQAL RGMSDLPPYG SGSSVQRQEP PISRSAKYTF YKDPRLKDAT
YDGRWLSGKP HGRGVLKWPD GKMYSGMFRN GLEDGYGEYR IPNKAMNKED HYVGHWKEGK
MCGQGVYSYA SGEVFEGCFQ DNMRHGHGLL RSGKLTSSSP SMFIGQWVMD KKAGYGVFDD
ITRGEKYMGM WQDDVCQGNG VVVTQFGLYY EGNFHLNKMM GNGVLLSEDD TIYEGEFSDD
WTLSGKDNSG LIEQVGKCSL LPYFLKVCEA LVLFLL
//
