ID B3KUZ5_HUMAN Unreviewed; 210 AA.
AC B3KUZ5;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 24-JAN-2024, entry version 59.
DE RecName: Full=Cdc42 effector protein 2 {ECO:0000256|PIRNR:PIRNR038036};
DE AltName: Full=Binder of Rho GTPases 1 {ECO:0000256|PIRNR:PIRNR038036};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG53607.1};
RN [1] {ECO:0000313|EMBL:BAG53607.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Uterus {ECO:0000313|EMBL:BAG53607.1};
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M.,
RA Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S.,
RA Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S.,
RA Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H.,
RA Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M.,
RA Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M.,
RA Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y.,
RA Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N.,
RA Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S.,
RA Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T.,
RA Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M.,
RA Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y.,
RA Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y.,
RA Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T.,
RA Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- FUNCTION: Probably involved in the organization of the actin
CC cytoskeleton. {ECO:0000256|PIRNR:PIRNR038036}.
CC -!- SUBCELLULAR LOCATION: Endomembrane system
CC {ECO:0000256|PIRNR:PIRNR038036}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR038036}. Cytoplasm, cytoskeleton
CC {ECO:0000256|PIRNR:PIRNR038036}.
CC -!- SIMILARITY: Belongs to the BORG/CEP family.
CC {ECO:0000256|ARBA:ARBA00010770, ECO:0000256|PIRNR:PIRNR038036}.
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DR EMBL; AK098292; BAG53607.1; -; mRNA.
DR AlphaFoldDB; B3KUZ5; -.
DR PeptideAtlas; B3KUZ5; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:UniProtKB-UniRule.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR InterPro; IPR029273; Cdc42_effect-like.
DR InterPro; IPR017363; Cdc42_effector_prot_2.
DR InterPro; IPR000095; CRIB_dom.
DR PANTHER; PTHR15344:SF4; CDC42 EFFECTOR PROTEIN 2; 1.
DR PANTHER; PTHR15344; CDC42 EFFECTOR PROTEIN BORG; 1.
DR Pfam; PF14957; BORG_CEP; 2.
DR Pfam; PF00786; PBD; 1.
DR PIRSF; PIRSF038036; Cdc42_effector_p2; 1.
DR SMART; SM00285; PBD; 1.
DR PROSITE; PS50108; CRIB; 1.
PE 2: Evidence at transcript level;
KW Cell shape {ECO:0000256|PIRNR:PIRNR038036};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR038036};
KW Cytoskeleton {ECO:0000256|PIRNR:PIRNR038036};
KW Membrane {ECO:0000256|PIRNR:PIRNR038036}.
FT DOMAIN 30..44
FT /note="CRIB"
FT /evidence="ECO:0000259|PROSITE:PS50108"
FT REGION 121..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 210 AA; 22474 MW; C8A882698F6FB69F CRC64;
MSTKVPIYLK RGSRKGKKEK LRDLLSSDMI SPPLGDFRHT IHIGSGGGSD MFGDISFLQG
KFHLLPGTMV EGPEEDGTFD LPFQFTRTAT VCGRELPDGP SPLLKNAISL PVIGGPQALT
LPTAQAPPKP SRLHLETPQP SPQEGGSVDI WRIPETGSPN SGLTPESGAE EPFLSNASSL
LSLHVDLGPS ILDDVLQIMD QDLDSMQIPT
//
