ID B3KVW1_HUMAN Unreviewed; 531 AA.
AC B3KVW1;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 24-JAN-2024, entry version 84.
DE SubName: Full=cDNA FLJ41625 fis, clone CTONG3009385, highly similar to Homo sapiens transmembrane and tetratricopeptide repeat containing 1 (TMTC1), mRNA {ECO:0000313|EMBL:BAG53923.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG53923.1};
RN [1] {ECO:0000313|EMBL:BAG53923.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Tongue {ECO:0000313|EMBL:BAG53923.1};
RA Ota T., Nakagawa S., Senoh A., Mizuguchi H., Inagaki H., Sugiyama T.,
RA Irie R., Otsuki T., Sato H., Wakamatsu A., Ishii S., Yamamoto J., Isono Y.,
RA Kawai-Hio Y., Saito K., Nishikawa T., Kimura K., Yamashita H., Matsuo K.,
RA Nakamura Y., Sekine M., Kikuchi H., Kanda K., Wagatsuma M., Murakawa K.,
RA Kanehori K., Takahashi-Fujii A., Oshima A., Sugiyama A., Kawakami B.,
RA Suzuki Y., Sugano S., Nagahari K., Masuho Y., Nagai K., Isogai T.;
RT "NEDO human cDNA sequencing project.";
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AK123619; BAG53923.1; -; mRNA.
DR AlphaFoldDB; B3KVW1; -.
DR PeptideAtlas; B3KVW1; -.
DR PharmGKB; PA142670718; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR44809; -; 1.
DR PANTHER; PTHR44809:SF1; PROTEIN O-MANNOSYL-TRANSFERASE TMTC1; 1.
DR Pfam; PF13414; TPR_11; 1.
DR Pfam; PF13424; TPR_12; 1.
DR Pfam; PF13432; TPR_16; 2.
DR Pfam; PF14559; TPR_19; 1.
DR SMART; SM00386; HAT; 3.
DR SMART; SM00028; TPR; 10.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 8.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|SAM:SignalP};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Transmembrane {ECO:0000256|SAM:Phobius, ECO:0000313|EMBL:BAG53923.1};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..531
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002788680"
FT TRANSMEM 32..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 60..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 132..165
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 197..230
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 231..264
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 265..298
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 332..365
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 400..433
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 438..471
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 472..505
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ SEQUENCE 531 AA; 60619 MW; D5AD921A12E37B20 CRC64;
MRNLATIFLA VVMALLSLHC LAAFKRLEHK EVLVGLLFLV FPFIPASNLF FRVGFVVAER
VLYMPSMGYC ILFVHGLSKL CTWLNRCGAT TLIVSTVLLL LLFSWKTVKQ NEIWLSRESL
FRSGVQTLPH NAKVHYNYAN FLKDQGRNKE AIYHYRTALK LYPRHASALN NLGTLTRDTA
EAKMYYQRAL QLHPQHNRAL FNLGNLLKSQ EKKEEAITLL KDSIKYGPEF ADAYSSLASL
LAEQERFKEA EEIYQTGIKN CPDSSDLHNN YGVFLVDTGL PEKAVAHYQQ AIKLSPSHHV
AMVNLGRLYR SLGENSMAEE WYKRALQVAH KAEILSPLGA LYYNTGRYEE ALQIYQEAAA
LQPSQRELRL ALAQVLAVMG QTKEAEKMTN HIVSEETGCL ECYRLLSAIY SKQENHDKAL
DAIDKALQLK PKDPKVISEL FFTKGNQLRE QNLLDKAFES YRVAVQLNPD QAQAWMNMGG
IQHIKGKYVS ARAYYERALQ LVPDSKLLKE NLAKLDRLEK RLQEVREKDQ T
//
