ID B3L484_PLAKH Unreviewed; 919 AA.
AC B3L484; A0A1A7VJF1; A0A384KTT6;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Phosphatidylinositol 3- and 4-kinase, putative {ECO:0000313|EMBL:CAA9987952.1};
GN ORFNames=PKNH_0831100 {ECO:0000313|EMBL:CAA9987952.1};
OS Plasmodium knowlesi (strain H).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=5851 {ECO:0000313|EMBL:CAA9987952.1, ECO:0000313|Proteomes:UP000031513};
RN [1] {ECO:0000313|EMBL:CAA9987952.1, ECO:0000313|Proteomes:UP000031513}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H {ECO:0000313|EMBL:CAA9987952.1,
RC ECO:0000313|Proteomes:UP000031513};
RA Pain A., Boehme U., Berry A.E., Mungall K., Finn R., Jackson A.P.,
RA Mourier T., Mistry J., Pasini E.M., Aslett M., Balasubrammaniam S.,
RA Borgwardt K., Brooks K., Carret C., Carver T.J., Cherevach I.,
RA Chillingworth T., Clarke T.G., Galinski M.R., Hall N., Harper D.,
RA Harris D., Hauser H., Ivens A., Janssen C.S., Keane T., Larke N., Lapp S.,
RA Marti M., Moule S., Meyer I.M., Ormond D., Peters N., Sanders M.,
RA Sanders S., Sergeant T.J., Simmonds M., Smith F., Squares R., Thurston S.,
RA Tivey A.R., Walker D., White B., Zuiderwijk E., Churcher C., Quail M.A.,
RA Cowman A.F., Turner C.M.R., Rajandream M.A., Kocken C.H.M., Thomas A.W.,
RA Newbold C.I., Barrell B.G., Berriman M.;
RT "The genome of Plasmodium knowlesi strain H, a zoonotic malaria parasite
RT with host range from monkey to man.";
RL Nature 455:799-803(2008).
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type II PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00008941}.
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DR EMBL; AM910990; CAA9987952.1; -; Genomic_DNA.
DR RefSeq; XP_002258932.1; XM_002258896.1.
DR AlphaFoldDB; B3L484; -.
DR STRING; 5851.B3L484; -.
DR EnsemblProtists; CAQ39705; CAQ39705; PKH_082870.
DR GeneID; 7320279; -.
DR KEGG; pkn:PKNH_0831100; -.
DR VEuPathDB; PlasmoDB:PKNH_0831100; -.
DR HOGENOM; CLU_317243_0_0_1; -.
DR InParanoid; B3L484; -.
DR OMA; IMPHIMD; -.
DR OrthoDB; 1699at2759; -.
DR PhylomeDB; B3L484; -.
DR Proteomes; UP000031513; Chromosome 8.
DR InterPro; IPR044571; P4KG1-8.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR PANTHER; PTHR45800; PHOSPHATIDYLINOSITOL 4-KINASE GAMMA; 1.
DR PANTHER; PTHR45800:SF11; PI3K_PI4K CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000031513}.
FT DOMAIN 163..440
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|Pfam:PF00454"
FT REGION 558..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 675..831
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 574..590
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 675..710
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 711..737
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 751..797
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 798..820
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 919 AA; 104459 MW; C764E1042BD5785E CRC64;
MGSNSLPMSQ QMYFSTHNAL RVNDENDVIS TLFYEINGNR HISLLIFPFY DVQMLKRLLI
KKLNLPGGVK VNDIIIFYKG IKLPNYRIIS TYLECTGRNE KNKKKKKKKI NKLYWAIKDI
NPNASIRVID QKSYPPFFEN ILHDIKLAFK KNISPKLTMD GTGGTYLLFN SKKKVCSVFK
PLDEEAFAPF NPRGYEGKMY QEGFRSGVLS GEGASREIAA YILDNSYNNF SSVPCTIMVE
ACNPHFNNKS KLKYVDHENN LKWKCGSLQE FVDSRESVGN YDHKQFSIRD IHKIAILDIR
VMNLDRNDGN ILVSPLKSLK DSCNQFLYRN NRSLGTSDED TLKRIVTIDN KPSRYSLIPI
DHGLIMPHIM DVAEIDLVWF EWPQTKVPFD DEELEVIFTF DPDKDAEKIR NKLLIREDCI
RTMRVCTRLL QIGARMHLNL HEIAKISTRK NIDEESVLEH LVRDSIVQAY QMMDYTSLMS
TNRLGYILDL AEIKINKKKK NSRMKSIENI DEALKERNET TDKTGINKME GGAFHFKPLL
EDKSKSLDCS YGKSLPSGNT FQDVGGMETA EDKLSGSNSR RMEKEDSAEG SGKLQIISES
VSCAPGGITP DHGKGNLSNA FEVTEKKEKS AYDGLYRGTL DVDLNIRSEQ KEENKTSTNS
FSNKSDYTLV TASSSSCING KGGSNSCSGE SPKGSAHGVG ENSPSSDGAS GKRGDKQDNR
GDDRPPPHSA SDQDTRVKGK KRKKKKKKKY FDKDDNKPVG EKREDEEGKG LPSDKPHNVS
EELQNETTKG DLLKGGVQDD EEEGDDESSS EEDEETDDEN DEVPFRKPTG TIKRITESSG
TAYRGMEMNK VNSVWMIRDK NNKIINVKWE NKIFEKLFFE TFENYVKRYI SDYHPEWKQY
PYKGSHISGI KHGYLKSIE
//
