ID B3MKQ8_DROAN Unreviewed; 2103 AA.
AC B3MKQ8;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 24-JAN-2024, entry version 78.
DE RecName: Full=HEAT repeat-containing protein 1 {ECO:0000256|RuleBase:RU367065};
GN Name=Dana\GF15432 {ECO:0000313|EMBL:EDV31589.1};
GN Synonyms=dana_GLEANR_16198 {ECO:0000313|EMBL:EDV31589.1};
GN ORFNames=GF15432 {ECO:0000313|EMBL:EDV31589.1};
OS Drosophila ananassae (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7217 {ECO:0000313|EMBL:EDV31589.1, ECO:0000313|Proteomes:UP000007801};
RN [1] {ECO:0000313|EMBL:EDV31589.1, ECO:0000313|Proteomes:UP000007801}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14024-0371.13 {ECO:0000313|Proteomes:UP000007801};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC {ECO:0000256|RuleBase:RU367065}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604, ECO:0000256|RuleBase:RU367065}.
CC -!- SIMILARITY: Belongs to the HEATR1/UTP10 family.
CC {ECO:0000256|ARBA:ARBA00010559, ECO:0000256|RuleBase:RU367065}.
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DR EMBL; CH902620; EDV31589.1; -; Genomic_DNA.
DR RefSeq; XP_001962368.1; XM_001962332.2.
DR STRING; 7217.B3MKQ8; -.
DR EnsemblMetazoa; FBtr0120132; FBpp0118624; FBgn0092457.
DR GeneID; 6498240; -.
DR KEGG; dan:6498240; -.
DR eggNOG; KOG1837; Eukaryota.
DR HOGENOM; CLU_001128_3_0_1; -.
DR InParanoid; B3MKQ8; -.
DR OMA; NDVMWKQ; -.
DR OrthoDB; 5480100at2759; -.
DR PhylomeDB; B3MKQ8; -.
DR Proteomes; UP000007801; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR012954; BP28_C_dom.
DR InterPro; IPR022125; U3snoRNP10_N.
DR InterPro; IPR040191; UTP10.
DR PANTHER; PTHR13457; BAP28; 1.
DR PANTHER; PTHR13457:SF1; HEAT REPEAT-CONTAINING PROTEIN 1; 1.
DR Pfam; PF08146; BP28CT; 1.
DR Pfam; PF12397; U3snoRNP10; 1.
DR SMART; SM01036; BP28CT; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367065};
KW Reference proteome {ECO:0000313|Proteomes:UP000007801};
KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274,
KW ECO:0000256|RuleBase:RU367065};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517,
KW ECO:0000256|RuleBase:RU367065};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552,
KW ECO:0000256|RuleBase:RU367065}.
FT DOMAIN 1823..1973
FT /note="BP28 C-terminal"
FT /evidence="ECO:0000259|SMART:SM01036"
SQ SEQUENCE 2103 AA; 236706 MW; 933D763D18715FBE CRC64;
MSTALAQQLK KLAAPQTSIP LADARSRASI LFDPKEAATK DRRAIYDIGV AGLQELTELN
PAFKEFHLTL FDEATLTLER AVELPEVNKM LDTAIGKFLR LLSPYLLLRP AHMAFEWLLR
RFQVHEYNRR AVMGLILPYH ETKVFVEVLK TMRIRTTDAD WAWLRRLQRP GAPLAKSAIV
NRAANNPAFL GFICKTTQKS VKELGPRAYQ LQAQINFYAT VVVGALQTAQ PLQDWHVTTI
LESLLKSLVS DNVDFMAAAY VIVAQLVSRT KLKSKVCNAL LERVGNCPFE RLQNESLLLL
LCIYGKQQHA VPHFTPGTIL NLVGQKWLIP ALTSLAKGNI AIQSICIPLM TGAVAAIRED
DPASVTHKQF LDNLLSEVPL ATPCAQQLIN CFLDCFVATE APEPMDTADY NDDTIIIDSD
DEAETEKTSF DTWYSSYLEK LERRYPTAFD LCVKEALRAK SKTSNRQQAL KIALGFRLNT
SDEKAKSAYE KLYHYSSDWR LNAVQQLLKS LNLPKKRERS VKLLQECLLD RINDDSGAVV
AALLGLPTET MVEILEPLEL AKTLCRLVQR AQSEKDAEWQ AVVPLAVHHL TTSHVSGHYD
SNLVLLALMP LLFPEKSLTK AEHQALLIVL GSEFAGRVSF LGELKVTQNF EEFKLNEHRQ
HFLDIISGTE QELVSQERAL LQSIEDHGGE AYLQDASQLT HLLLLLTAYA KRELPAKESL
HMLEKISLYS PRIQFRIVKG HGSAQEFVPL QLYLDFLLTL VKNTKWTSLA SVPWTEITDE
LRLCLRLLEI HCKQVFVERS DQSEHLEWTR SLQQCLTLIL PSAQDRLDLL TNFYIFERLP
ELWPRNLDYT VFRLQGFLLL DAVLSNQKSQ LDCSLVHVLR VANACGSPLQ TLRLQAINTL
QLMSTRKLVG HVEQLVRLLL QRRSELGMDH EQYALILYTI LEPENATAKE KLVLSKLKRA
VLALASDPEQ APTCTAALLT ALKHVNNEHF LGELLPLGLA SLKKITAAVG EQQLKQLPWP
HSDIYKSVME RFEGNVALNV LLQKPLAWEL LEASFAHHDA YIQLEKKLQP LPCVLLNSLT
PETFERLQAQ HKVALIKLIV EAATLSDNDS IFLASHRLLK RCRLECKPLV PILAEMAASK
GLKPQQARAK PTNKRRSGGE ALQLDLTSLS WKKGMTLLEL LEHKKLLVGA ELLIPALFDL
LQGCVTLEEH SAAEYPKQLI LTSLLHSCQM AQAAGIQLAK TLPESSFRIE LVVQCLRNTR
NPQTQQHALL FLAHCAGMYP QQVLHKIVEI FTFVGSTVAR HDDAFSLHII HNVVESIIPI
LLQTTGQKEQ LIIPVLKVFA DICTDVPVHR RLPLYATLFR VLDPKEHLWQ FLCILFEAQV
MLEQGSKKGS TEKSRLDFAS ELTLMFEDPA VGLQTAVRLL DYLAKLPANK GTQLTAEARN
SSVLDTEQKL FDVRNNSFKQ LRHYKYLIME FLSGISSSKE WQAKMKRPDP TELLPHYQDF
ILNTLAYVGV VNGAIVSTAE TPLLQKYWRV LANYAHDVLD NAIGLLAPEH FLSVITELLQ
HDLVHVRIKV LELLVTKLGP TNDYFQQSPP DHFGVLFAPL ESIINGILEG GAANAQHAQL
QQTALHALQL LAHRHGRDFI DECRSLLATL TKITKRRSNV PKAVVGNVVL TLVEICASLK
AHALAQLPKF APQLTELLKE QVHHMTTQKT GPDYLCSTLV NALLKLFKAL PLFLGPYLVD
IIGALVRLGV QLDHPQLLQD KRAQALRSQL VEVWSAVAQG VEVRILVPSC SKAYSCLLEH
QAYDEVGQLM QQLLLQCIRH NATQQLLPVQ DALSELFLQA LEFRLQVRGR GVDRQTVSEV
EGAIAETFVT WILKLSEANF RPMYSRVHKW ALESNEKETR LTYFLLTKRI AEALKSLFVL
FASEFVDDSS RLLAEHNTLR AEFSAGDRED DVELLTAILG TLHNVFLHCS EDFINEHRFN
ALMTPLVDQL ENDLVLGCEQ LQQALTNCIA QLAVATNDVM WKQLNGQVLL KTRTPTPEVR
ILAFNTCVAI ARKLGEGFAP LLPETVPFIA ELLEDEHQRV EKNTRTAVQE LESILGEPVQ
KYL
//
