ID B3NWU8_DROER Unreviewed; 2276 AA.
AC B3NWU8;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 2.
DT 24-JAN-2024, entry version 79.
DE RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
GN Name=Dere\GG18180 {ECO:0000313|EMBL:EDV46495.2};
GN ORFNames=Dere_GG18180 {ECO:0000313|EMBL:EDV46495.2};
OS Drosophila erecta (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7220 {ECO:0000313|EMBL:EDV46495.2};
RN [1] {ECO:0000313|EMBL:EDV46495.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TSC#14021-0224.01 {ECO:0000313|EMBL:EDV46495.2};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
RN [2] {ECO:0000313|EMBL:EDV46495.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=TSC#14021-0224.01 {ECO:0000313|EMBL:EDV46495.2};
RX PubMed=18057021; DOI=10.1093/bioinformatics/btm542;
RA Zimin A.V., Smith D.R., Sutton G., Yorke J.A.;
RT "Assembly reconciliation.";
RL Bioinformatics 24:42-45(2008).
RN [3] {ECO:0000313|EMBL:EDV46495.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=TSC#14021-0224.01 {ECO:0000313|EMBL:EDV46495.2};
RG FlyBase;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CH954180; EDV46495.2; -; Genomic_DNA.
DR RefSeq; XP_001977568.2; XM_001977532.2.
DR EnsemblMetazoa; FBtr0414208; FBpp0372473; FBgn0110396.
DR GeneID; 6550071; -.
DR KEGG; der:6550071; -.
DR eggNOG; KOG3522; Eukaryota.
DR HOGENOM; CLU_001213_0_0_1; -.
DR OrthoDB; 2916834at2759; -.
DR Proteomes; UP000008711; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0007480; P:imaginal disc-derived leg morphogenesis; IEA:EnsemblMetazoa.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR12877:SF7; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10-LIKE PROTEIN; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF19056; WD40_2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}.
FT DOMAIN 992..1179
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 108..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 360..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 567..767
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 819..911
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1311..1330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1464..1499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1920..1944
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1961..2009
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2072..2207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2220..2264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 55..101
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1162..1192
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..585
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 586..600
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 601..620
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 621..652
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 654..672
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 696..711
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 712..739
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 748..767
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 882..910
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1925..1944
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2078..2102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2111..2161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2185..2204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2222..2264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2276 AA; 245021 MW; 1C61D45DD3DEFE8A CRC64;
MESLGLGSRR NNGSSSTAAP TTGQGGVVGG GGVASKVLVH TKLKQQQQHS NQNYYTQQQT
QLQRLKQQQQ KLQQQQQQQQ QQQQQQQQQQ QQQQQQQLEA VHGGVAKQCL QFPPPPDYPP
PTATGGGGSS PVNTSGRRQQ LPRYPDPDPD AIEICNETAT LETSPYHLKQ LAARHSKTLG
RNLNHQQHHQ HTVHLHHDYS YAYYEPGAAM RHSNVPGAVT PGGGGGGGVA GGVSLVVDAT
TSSSPTAEPP PNSIRALLSK GKKNKQLVSP ATLQSYQTRY HKLTTKSGMG QSENFYEEIN
AAALQTSGGH HLRSTVGSHS AGSLNQTLVE EELRRVQNRH HKILGELNLS VEAMLMPESP
PKCIEQQPQG AGSAAAGGAE VTPPQPSVSV TAASGQPPTI LARLTSASAD NICDSGGGEA
GKRSKGAAGC PGGGVEQLLT ATCGDLDSGF SGSSGASYIG SLRLSKTQHN KCARQAPTAG
TQSCRSFQRA ATVYDEAGMT GGGGSSFLTR ASCGRRILSC ARIRAAEDPG PNHRIAGGNG
IQAVQSTATE SKARSFWSRK GWRKLPGFST STSSINDTGL SDEHKLSSGS WEDTLDEPHH
HHAHHSHHQH HLHQHHSHLN QRHQQQQLQQ TSFIGSPPSS ASITTAQLHS AFSRRIAEQR
ERDQRDQRDQ RDPAGCTAAT IAGGSFSANG GQAAVGVGVG SSSSCGSSSE RDTKSPCRER
DRNLERDRDR ERDKNEDLGE EEVLTEEEQT SSSVSSLSAG NQRNSQLRST FNKAKQHLSF
DKWRTAATGS ATGSASGPGS SATESNNAAS NMIMRRASAC TMPSTGGGGA GGSGGGGSGG
GSQREEATTP GESPGGRLSR WFSIRRGSSH QYDVGGRDGR HSTASSFDTP DSSSGNSPKN
GSNSAAGSVG AGSQGVALDA ASPQKLANLG ASKMMPGVPE SEDDEATANR FDMDLMITPG
SRANGTARTA HNRLIVPMLP PAPAGLSQQQ LKRRHIVAAI VHSENSYVAT LQRLVNDYKK
PLEECSPPVL NPVKIATLFH CLPDILHSHK LFRISLAECV RNWDRDEKIG DCFVSAFGKP
QLLEIYSGFI NNFSAAMELA KMEEKRKSAL ADFFKVKQIS AHDRLSFFGL MVKPVQRFPQ
FILFLQDLLK YTPQGHHDRM SLQLALSQLE LLAELLNESK REAEQYQAFK EMLGHISGTF
NARSLSLSSV SVSDSAGGHR PRYLLREDNV THMEFNQAGF IVKCKQRRLL LLNDKVICVS
VAPKQSHDFG ATEKLTFKWM FPVNDVEIVD NSTSATLSRI LTAGLNRGGS LKSNGSSGAN
GSPYANSTLP GHGGGSSGFS GFGDPHSSPA AQLTNGADNL CSEMSTLMYD YEVISRIQDL
VSSLKGSYKE LNANTTRNVL NLIQGSIQRK DEEMAWVDSC CLQLIGRHKS GKEETFTFQT
QTPAVKKEWI TELRLAQLAL DPNNSPAWER GGSHPQSAHH HPHHALQHPL QHPHAGAGDP
RQTLEQLLLQ EAVQQKQSRK MPLFVKAMPV YKSQHQTEVR CGCYYSIAND TKQSGNARRR
HKQLNYLWMC SSDGTSSHIT VLAQHPQQAG NLREAGAFDL FETQVSALEF VKGLDQLKSR
DEPASLLGDL VWLGTDSRKI LVYSARNPEQ EEQLGSYSVP GAVQRILYHF DAVYVALSGA
TVLIFRRGND GVWQLRDPQT IRLGDTDLAV PSLLPINMCI YASCGNRVYV MNALNGEIQR
SFEVQHGATQ QVNLMAHSGI GLWISLKNST MLCLYHTETF KHLQDINIAS SVLRHDGKKE
QPLNNSSVYV TALMACKGLL WVGTNVGIAV TIPLPRLEGV PIISGGINMS CHAHFGPITF
LLPLIPKVYP TYKPPTVGAA PLVPSMGDDL QLPAIDADPK IQELDDGAVV LRRDLVKEEM
AASNPGADST ASSPRSSKLD KQNSLDQSFT AKIRASLANS PAFHRKRFRD DPNRMSKTLP
RGLGAAAAGS GAGGASAAAT ASGNTSQHGE HGICDVYGLY GKLIFVKEDY DAEEGNQGNL
MDMMYEGMRR SDPELAAIPG KVCTLDRRLR MKASRPRSLD LSNWSVDSKS SSLYTSSGSE
ESMGIRHFGG RSVSRNSSSA SHKTSGTGSD LGNISENGLM TTADIHHHQQ QQQQLNSSAK
PEEMNRLGAG NSGLDKPAAA VATLKRKQKQ NTKQQQQQNA DGPRTVITLM GGRGYWRQMW
YNGTGGSPSH KNSSSGGGGG SGSGFGSQTM QSGNPSCSPL TANSNDAHIV VWEKKL
//