ID B3RM29_TRIAD Unreviewed; 655 AA.
AC B3RM29;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=CSC1/OSCA1-like 7TM region domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=TRIADDRAFT_52212 {ECO:0000313|EMBL:EDV29627.1};
OS Trichoplax adhaerens (Trichoplax reptans).
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV29627.1, ECO:0000313|Proteomes:UP000009022};
RN [1] {ECO:0000313|EMBL:EDV29627.1, ECO:0000313|Proteomes:UP000009022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV29627.1,
RC ECO:0000313|Proteomes:UP000009022};
RX PubMed=18719581; DOI=10.1038/nature07191;
RA Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA Rokhsar D.S.;
RT "The Trichoplax genome and the nature of placozoans.";
RL Nature 454:955-960(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; DS985241; EDV29627.1; -; Genomic_DNA.
DR RefSeq; XP_002108829.1; XM_002108793.1.
DR AlphaFoldDB; B3RM29; -.
DR STRING; 10228.B3RM29; -.
DR EnsemblMetazoa; TriadT52212; TriadP52212; TriadG52212.
DR GeneID; 6749307; -.
DR KEGG; tad:TRIADDRAFT_52212; -.
DR CTD; 6749307; -.
DR eggNOG; KOG1134; Eukaryota.
DR HOGENOM; CLU_015647_0_0_1; -.
DR InParanoid; B3RM29; -.
DR OMA; EEYPLEH; -.
DR OrthoDB; 231434at2759; -.
DR PhylomeDB; B3RM29; -.
DR Proteomes; UP000009022; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IBA:GO_Central.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR PANTHER; PTHR13018:SF153; RE44586P; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009022};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 43..60
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 176..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 421..441
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 491..521
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 548..568
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 580..601
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 132..242
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 257..376
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 413..562
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 111..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 655 AA; 74429 MW; 3648046332B16C0F CRC64;
MSTYDTLYGV IFNSSNFSCG VDAPSNATSI FGHVVYGGVP QNLLINFIVW VIMLLIFSIL
RRSASQTNET LLGDADRRWI NVFYSSVHEP TEDDNDTDVV TVTRPQGAIQ DTKTDDSEIN
NGENSHLQHQ TVNDGSPTAN NKWLFSWISN LIHLSLSDIE KKCGADSVRY LIFQQYMILL
LVVYTVLSIG IILPVNIQGL LDSQDKFDAT TITNINPRAP VLWLHTVFAV LYLLINIILM
YRYSTQLGVR RNEMSSNTIC VRGLPKNTTD KNLIKQHFEE AYNACQVTAV EFAYDIKLLT
KYYRDKHLYG ACLRFCQRQY DTTGERPMIG YCTCCNCRGC KQADGITYYT NNLELASSNY
DKELQRFAAS TSAFVTQVFP TIMLWAIGSL LPLTVVTLSG YEVFTKNAAA FFELTFDRGT
FLTQLQCVFL ANNGAFFVNY LITSAFIGNA SEILRLPEMV ILGFKMLFTK STPERETLKL
KEKGFDFGSQ YSWILVTITI AIIYSLSCPL VTPFGLVYLV LKHYTDKYNM YYVKSRTAYY
DSEIHDTAIS FSVFGTIMML GCVLFYNILR IGTADARSVF TFVILIISLV FYFGVIGFNV
CSRFIPKKKY MTEEDSNSGR NYTYLPFVLM QEKSFTQQTV NEDKMPAERS YGTYQ
//
