UniProt: B3RPT9

Database: UniProt
Entry: B3RPT9_TRIAD

LinkDB:  B3RPT9_TRIAD 
Original site:  B3RPT9_TRIAD

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Ontology (10)   
   GO (10)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (32)   
   InterPro (19)   
   Pfam (12)   
   SMART (1)   
Literature (1)   
   PubMed (1)   
All databases (47)   

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ID   B3RPT9_TRIAD            Unreviewed;      4464 AA.
AC   B3RPT9;
DT   02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   02-SEP-2008, sequence version 1.
DT   27-MAR-2024, entry version 86.
DE   RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
GN   ORFNames=TRIADDRAFT_20411 {ECO:0000313|EMBL:EDV28243.1};
OS   Trichoplax adhaerens (Trichoplax reptans).
OC   Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC   Trichoplax.
OX   NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV28243.1, ECO:0000313|Proteomes:UP000009022};
RN   [1] {ECO:0000313|EMBL:EDV28243.1, ECO:0000313|Proteomes:UP000009022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV28243.1,
RC   ECO:0000313|Proteomes:UP000009022};
RX   PubMed=18719581; DOI=10.1038/nature07191;
RA   Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA   Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA   Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA   Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA   Rokhsar D.S.;
RT   "The Trichoplax genome and the nature of placozoans.";
RL   Nature 454:955-960(2008).
CC   -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC       {ECO:0000256|ARBA:ARBA00008887}.
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DR   EMBL; DS985242; EDV28243.1; -; Genomic_DNA.
DR   RefSeq; XP_002110077.1; XM_002110041.1.
DR   STRING; 10228.B3RPT9; -.
DR   EnsemblMetazoa; TriadT20411; TriadP20411; TriadG20411.
DR   GeneID; 6750747; -.
DR   KEGG; tad:TRIADDRAFT_20411; -.
DR   CTD; 6750747; -.
DR   eggNOG; KOG3595; Eukaryota.
DR   HOGENOM; CLU_000038_9_1_1; -.
DR   InParanoid; B3RPT9; -.
DR   OMA; QRENMAG; -.
DR   OrthoDB; 166463at2759; -.
DR   PhylomeDB; B3RPT9; -.
DR   Proteomes; UP000009022; Unassembled WGS sequence.
DR   GO; GO:0097729; C:9+2 motile cilium; IBA:GO_Central.
DR   GO; GO:0005930; C:axoneme; IBA:GO_Central.
DR   GO; GO:0030286; C:dynein complex; IBA:GO_Central.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR   GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR   GO; GO:0008569; F:minus-end-directed microtubule motor activity; IBA:GO_Central.
DR   GO; GO:0060294; P:cilium movement involved in cell motility; IBA:GO_Central.
DR   Gene3D; 1.10.287.2620; -; 1.
DR   Gene3D; 1.10.472.130; -; 1.
DR   Gene3D; 1.10.8.1220; -; 1.
DR   Gene3D; 1.10.8.710; -; 1.
DR   Gene3D; 1.20.1270.280; -; 1.
DR   Gene3D; 1.20.58.1120; -; 1.
DR   Gene3D; 1.20.920.20; -; 1.
DR   Gene3D; 1.20.920.30; -; 1.
DR   Gene3D; 3.10.490.20; -; 1.
DR   Gene3D; 6.10.140.1060; -; 1.
DR   Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR   Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR035699; AAA_6.
DR   InterPro; IPR035706; AAA_9.
DR   InterPro; IPR041658; AAA_lid_11.
DR   InterPro; IPR042219; AAA_lid_11_sf.
DR   InterPro; IPR026983; DHC_fam.
DR   InterPro; IPR041589; DNAH3_AAA_lid_1.
DR   InterPro; IPR042222; Dynein_2_N.
DR   InterPro; IPR043157; Dynein_AAA1S.
DR   InterPro; IPR041466; Dynein_AAA5_ext.
DR   InterPro; IPR041228; Dynein_C.
DR   InterPro; IPR043160; Dynein_C_barrel.
DR   InterPro; IPR024743; Dynein_HC_stalk.
DR   InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR   InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR   InterPro; IPR013602; Dynein_heavy_linker.
DR   InterPro; IPR013594; Dynein_heavy_tail.
DR   InterPro; IPR042228; Dynein_linker_3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR   PANTHER; PTHR45703:SF8; DYNEINS HEAVY CHAIN; 1.
DR   Pfam; PF12774; AAA_6; 1.
DR   Pfam; PF12775; AAA_7; 1.
DR   Pfam; PF12780; AAA_8; 1.
DR   Pfam; PF12781; AAA_9; 1.
DR   Pfam; PF17857; AAA_lid_1; 1.
DR   Pfam; PF18198; AAA_lid_11; 1.
DR   Pfam; PF08385; DHC_N1; 1.
DR   Pfam; PF08393; DHC_N2; 1.
DR   Pfam; PF17852; Dynein_AAA_lid; 1.
DR   Pfam; PF18199; Dynein_C; 1.
DR   Pfam; PF03028; Dynein_heavy; 1.
DR   Pfam; PF12777; MT; 1.
DR   SMART; SM00382; AAA; 3.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 5.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Cilium {ECO:0000256|ARBA:ARBA00023069};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Dynein {ECO:0000256|ARBA:ARBA00023017};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW   Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009022}.
FT   DOMAIN          1845..1981
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          2123..2254
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          2450..2595
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   COILED          769..796
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          3030..3115
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          3267..3315
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   4464 AA;  512752 MW;  1A4F84221B8AD137 CRC64;
     MSNDNDNVDV RLEWISEYVL RTLKVKYEKW QKMYTIDENK NIIQQVLDKS DQMILVFYSN
     SAGALCVSLE FPSTLKQKAV YFIKKAREPI PKENFKAALN YGDLSNSPLE QLSALVDEVL
     VPILTNSKNH EQWPSVVSQD VLRHVHSLKS NVYVIAGQVK GKTLLPLPVG SERMIEESDD
     KEETWSRGLV HAIESAVIEW SHQIRDVLKR DSAQPLLEGL NPLPFTEIVF WKAKCANLEC
     IYEQLRDPKV RKMAELLEKT QSSYFPSFKK TFQDVVTGLN EARDISIHLK PLKPLLEDLE
     QTEFDAIKKS IPPLFHTIGL IWANSKYYST PARIIVLLQE LSNMIIELAR NFLDASELFK
     GEIEETIGRV TKTINICRYY RQHFDETKAN ISKFFKGVGT NVREWEFSPT LIFTRYQKFV
     ERLQHVQEIM ETALDFYKLE KVELGGIKGK TLSQQVVQIF NEFSEYMQVF TNTTYDTLDI
     NNEDFVNDYE SFKRKVYDLD RRLGSIVCQG FEDCSGVEAI FKLINCFGSL LNRPVIKTDF
     EHKYAILLTL FNKELDNAKK IYDIQIASEK NKEGSAPINK NMPNVAGNLQ WAREIRHRIS
     VPMASLKQLD HQNIQDTPEA QEIFRKYEEM IELLQKYEGK KFEAWSEVVG DEAKYNLERS
     LIVRNEATNL IAVNFDPQLV AVLREVKYLE MRDKETIPGS AAEIYSKNET FRQYLGSLDL
     IVMWYNKVRE TVLEVEFPLI EDRLKEIDEQ LLKAETELNW NSEGIWEYIK STREKVHDLE
     KRVQKAKDNV EAMSKDMAKW AVSPLYERKD DKKDALLNVE DREMQLNNRY NLIKQSGERL
     HNLLKENYEL FEANEDSDIW RAYVDYLDDM IVDGFFNAIH CSLSYMLDNT DPKINTAPLL
     EARLDLSAPD MIFTPPLDIG AHNSFYDLVE SLLSDVYRQA SLVSRLAKHN GMDHYQSDLE
     DMLELSEMRQ ELMDRIQNIM NKACEYRNSF DTYSYLWVDD RHEFMRQFLL YNHVLTPEEI
     EQHAEDGVPE CPPTLEQFKE QIDTYERIYN EVDDVDGTSI FDTWFRVDIR PFKQSLLNTV
     KRWSYMFKQH LIDHVTNSLA ELENFIKSTD TGLTLQIEEG DYDGLVAVMG HLLAVRDRTS
     ATDELFEPLK ATIDLLKTYE QEMSEEVHNQ LRELPEKWNN TKKISVTVKQ SVAPLQAAEV
     AIIRRKCGQF EVKQHEFREW FRAYAPFRFD CEDPYDRLDS AHLETHTLEE EMNQLAQSAS
     LFEVNVPDYK QLKACRREIR LLKTLWDMIS MVMSDIDDWK TTYWSEINVE SMDADCKKFA
     KEIRELDREI RSWDAYNGLS STVKNMMTSL RAVSELQNSA IRERHWQQLM AATQVKFVMD
     NSTTLADLLA LNLHKYEDEV RNIVDKAIKE LSMEKILKEL DVTWSTMEFE YEQHARTQTP
     LLRSSEELIE TLEDNQVQLQ NLITSKHISH FLEEVSSWQK KLSTADGVIS IWFEVQRTWS
     HLESIFIGTE DIRKQLPEDS KRFDGIDADF KDLMADAQKT PNVVEATNKP GLFNLLEDIQ
     GRLSLCEKAL AEYLETKRLA FPRFYFVSSA DLLDILSNGN RPSEVARHLS KLFDSIARLK
     FEEDENGELT KVAIGMFSKD GEYVDFNTSC SCTGQVETWL NRLLDTMRST IKHQLTEAVV
     TYEEKARDQW IFDYPAQVAL TGTQVWWTTE VNIAFSRLEE GYENALKDYN KKQIAQLNSL
     ITMLLGDLSK GERQKIMTIC TIDVHARDVV GKLIQQKVEN AQAFVWLCQL RHRWDDDKKD
     CFANICDAQF CYSYEYLGNQ PRLVITPLTD RCYITLTQSL HLTMSGAPAG PAGTGKTETT
     KDLGRALGCM VYVFNCSEQM DYKSIGNIYK GLAQTGAWGC FDEFNRISIE VLSVVAVQVK
     SIQDAIRDRK ERFVFQGEEI SLTPTVGIFI TMNPGYAGRT ELPENLKALF RPCAMVVPDF
     ELICEIMLVA EGFLDARLLA RKFITLYTLC RELLSKQDHY DWGLRAIKSV LVVAGSLKRS
     DRQRPEDQVL MRALRDFNTP KIVTDDLPVF LGLISDLFPS LDVPRKRDLE LEAIVKTSTQ
     QLNLQPEDSF ILKVVQLDEL LAVRHSVFVI GAAGTGKTQI LRTLHKTYQN QKRKPVWHDM
     NPKAVTTDEL FGCINSATRE WKDGLFSVSM RDLANLSGDG PKWIVLDGDI DPMWIESLNT
     VMDDNKVLTL ASNERIPLTP SMRLLFEIGH LKYATPATVS RAGILYVNPT DLGWSPYVTS
     WIDTREVQSE KANLIILFDK YVPTCLDTLR NRFKKITPVA DISMVQTLCY LLEVLLTEDN
     VPPDSPKEHY EIYFVFAAVW AFGGAMFQDQ LVDYRVEFSK WWVSEFKTIK FPSAATVFDY
     QVDRETKKFV PWAEKVPKFE FDPELPLQSA LVHTAETIRV RHFTRLLMQR GRPVLLVGNA
     GTGKSVLVNN VLQSLGDDYQ LTFIPFNHYT TSAMLQGILE KPLEKKAGRN YGPPGTKKMV
     YYVDDLNMPE VDTYGTVSPH TLIRQHLDYK HWYDRNKLLL KDIHNCQYIA CMNPTAGSFT
     VNPRLQRHFC VFALSFPGSD ALHTIYNSIM QAHLDSFTFP SSIYKISQNL VNAAISLHHK
     VTSHFLPTAI KFHYTFNLRD LSNIFQGILF STPDCIRVQT DLVRIWMHES YRVYSDKLVD
     DKDLEYFDRL VADMVRKNFD DIDEEPLAVR PLLYSHFSGG IGDLKYMPIQ DWHSINKILE
     EALDSYNEMN AVMNLVLFED AMQHVCRINR ILESPRGNAL LVGVGGSGKQ SLARLASFIS
     SLDVFQITLR KGYAIADLKL DLASLCTKAG LKNIGTVFLL TDAQIPDEQF LVLINDLLAS
     GEIPELYPDD EVDNIIGSLR AEVRGSGMQD TKENCWKFFI DRVRQNLKVV LCFSPVGSTL
     RVRARKFPAV VNCTSIDWFH EWPEEALIRV SKRFLDEVDI LDTDIKDSIS QFMAYVHTSV
     NEMSKVYLTN ERRYNYTTPK SFLEQIKLYR NLLKKKSKEL TSKMERLENG LLKLESTSSQ
     VDDLKAKLAS QEVELKQKNE DADKLIQKVG IETEKVSKEK EIADEEEKKV ALIAQEVAEK
     QKSCEEDLLK AEPALVAAKE ALNTLNKANL TELKSFGQPP EAVKNVTAAV MVLLATPNKI
     PKDRSWRQAK LMMSRVDTFL ETLINFDKEH IDDSNLKALQ PYLNNPEFNP DFIRNKSLAA
     GGLCSWVKNT VVFYNVYCEV EPKRIALEQA NAELAAAQEK LANIKVKINI LDDNLSRLTA
     EFEKATSEKL KCQQEADTTA KTITLANRLV GGLSSEKIRW NESVVNLKHQ EITLPGDVLL
     TAAFISYVGC FTRNYRADLT GHKWIPFLQQ QKVPIPITED LDPLTLLTDD ATVAGWNNEG
     LPSDRMSTEN ATILANAERW PLMIDPQLQG IKWIKNRYGE ELRVVRLGQR NYLDIIERAV
     SNGDIVLIEN LDEIIDPVLD PLLGRNTIKK GKFIKIGDKE VEYHPDFRLI LQTKLANPHY
     KPELQAQATL INFTVTRDGL EDQLLAEVVS KERPDLEKSK ADLTKLQNDF KIRLKELEDS
     LLSRLSAAEG NFLGDYSLVE NLEVTKRTAS EIEVKVTESK ATEIEINQAR EHYRPAAARA
     SLLYFILNDL HKINPIYQFS LKAFNAVFNK AIDRAEVADD VKVRVANLID IITYSVYAYT
     SRGLFESDKL IFAAQVTFQV LLMNKEIWAN ELDFLLRFPV VQNIISPVDF LSHHAWGGIK
     ALASMDEFRN LDRDIEGSAK RWKKFVESEC PEKEKFPQEW KTKSSLQKLC MLRALRPDRM
     TYAISNFVEE KLGHKYVENR QIEFSRSFEE SSPATPIFFI LSPGVDPLKD VEALGKKLGY
     TISAGSLHNI SLGQGQEIVA EQSLDLAARE GHWVILQNIH LVAKWLPTLE KKIETYSEGS
     HENYRVFMSA EPAPTPESHI IPQGLLQASI KITNEPPTGM QANLYKALDN FNQDTLEICT
     RESEFKSILF ALCYFHAVVA ERRKFGPQGW NRPYPFNTGD LTISVNVLYN YLEANTKVPW
     TDLRYLFGEI MYGGHITDDW DRRLCKTYLE EFMRADLLDG ELQFAPGFPV PPNSDYKGYH
     LYISEMLPPE SPYLYGLHPN AEIGFLTTTS NSLFRTVLEM QPRDAGAGGG AASTREEKVK
     QTLDEIIEKL PEEFNVSEMM ARIEDRSPYT VVAFQECERM NILTSEIRRS LKELDLGLKG
     ELTISADMEN LQNSLFLDKV PDSWTKRAYP SLSGLAAWYS NLLLRIKELE NWTTDFALPN
     VVWLAGFFNP QSFLTAIMQS MARKNEWPLD KMCIQCDVTK KSKEDFNSPP REGAYIHGLF
     MEGARWDVQS GVIQDSKLKE LTPSMPVIFL RAITVDRQET RNIYECPVYK TRQRGPTFVW
     TFNLKTKENS SKWILAGVAL LLST
//

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