ID   B3RX43_TRIAD            Unreviewed;       944 AA.
AC   B3RX43;
DT   02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   02-SEP-2008, sequence version 1.
DT   27-MAR-2024, entry version 86.
DE   RecName: Full=DH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=TRIADDRAFT_56986 {ECO:0000313|EMBL:EDV24807.1};
OS   Trichoplax adhaerens (Trichoplax reptans).
OC   Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC   Trichoplax.
OX   NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV24807.1, ECO:0000313|Proteomes:UP000009022};
RN   [1] {ECO:0000313|EMBL:EDV24807.1, ECO:0000313|Proteomes:UP000009022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV24807.1,
RC   ECO:0000313|Proteomes:UP000009022};
RX   PubMed=18719581; DOI=10.1038/nature07191;
RA   Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA   Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA   Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA   Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA   Rokhsar D.S.;
RT   "The Trichoplax genome and the nature of placozoans.";
RL   Nature 454:955-960(2008).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DS985245; EDV24807.1; -; Genomic_DNA.
DR   RefSeq; XP_002112697.1; XM_002112661.1.
DR   AlphaFoldDB; B3RX43; -.
DR   STRING; 10228.B3RX43; -.
DR   EnsemblMetazoa; TriadT56986; TriadP56986; TriadG56986.
DR   GeneID; 6754344; -.
DR   KEGG; tad:TRIADDRAFT_56986; -.
DR   CTD; 6754344; -.
DR   eggNOG; KOG0274; Eukaryota.
DR   eggNOG; KOG3524; Eukaryota.
DR   HOGENOM; CLU_013595_0_0_1; -.
DR   InParanoid; B3RX43; -.
DR   OMA; DKCRESK; -.
DR   OrthoDB; 2910789at2759; -.
DR   PhylomeDB; B3RX43; -.
DR   Proteomes; UP000009022; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd22173; F-box_ECT2L; 1.
DR   Gene3D; 1.20.1280.50; -; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR46857; EPITHELIAL CELL-TRANSFORMING SEQUENCE 2 ONCOGENE-LIKE; 1.
DR   PANTHER; PTHR46857:SF3; F-BOX DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF12937; F-box-like; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF81383; F-box domain; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000009022}.
FT   DOMAIN          84..130
FT                   /note="F-box"
FT                   /evidence="ECO:0000259|PROSITE:PS50181"
FT   DOMAIN          652..769
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   REGION          185..218
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          247..281
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          599..649
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        621..639
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   944 AA;  109095 MW;  FE2DBA250B58C617 CRC64;
     MKSSTKLMEN MPVSSMKKSA WTPRSSPANE KLYLERVELV GHWFDMWSDV QRKRFLDYIL
     HRSKRSQLHF VESWCDHRVA RRNLDFTNHL PRFLSLYIFS FLDPRSLCRA AMVSWNWKFL
     AEQDAIWMPK CVRYGWYLPY APSSREYGAW KFHYLACMTS LQVEAPSQDV VEMYRQFNEV
     TLGDHKYRGE KQGRRSKSPT KMSRKSVEGQ PWLDPDPVPK ETHFQFSEDY DPHTPFSAAP
     NSLLLKSTGK QRRSKIEDVP SKSYQVGAPY EDPELSPRST LSSHIVRESS KNLLLNTDYR
     GDFRIKSKRH DLSGGFYPKL PTNQRDLRAL SLNFPNHANP RVIFISSRIP AAELLHEAVM
     FGVLPIVYSY NSTTLEILLQ QLHYVLNGRQ ARSIGFFVHY QHPGQINLVA DKTTSVKSLS
     QADIKTFWET LCGFVVAADI GGHVDIFTPL ADSEEGMELI LQLGIITGMQ FSAPSCVAES
     FIDVNSDWLL TPGGVTPPAL YFHLQKLATW SYVSQQVKEA SESVQKHLSL YIDQQRKDVI
     SKLTGKIIFD AMSLGEVYQT SKIGNLIRDA IISLSSAENQ DKVDTAAYIA DYLQGRREKE
     EKKKKKKKKK EKTNNDEDHA EEEDQRLEEE EETDHDDKQE KIEEEDKKSE ERRTLIVHEL
     FSTELNYMRT LEIIETAFVN PLRAAMGSNK GLLEDLTPRV RSWTSEQVIG DIFRKFTVKL
     KTYTNYINNY TVTLSTIEKC QEQFPGFRVF LKRTERKTQT KMLSYVKLLT ALANQAPPNH
     PDHKELPLQI KQLQHVLSFI AEARARAERD RKMIALQKRI ENCPTLIEGN RHFITEECVT
     NLKLYSPIED LGLLLFNDAL VVTHRKSRYF PFIRAVEQTD KFFVSVALIR LTVDDVADTK
     YAKNVFKMST PKREWICQAS SPEAKWRWIS ILEKSIDNAI EVES
//